Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Rafael Paternostro"'
Autor:
Lorenz Balcar, Benedikt Simbrunner, Rafael Paternostro, Mathias Jachs, Lukas Hartl, Georg Semmler, Benedikt Silvester Hofer, Albert Friedrich Stättermayer, Matthias Pinter, Ton Lisman, Michael Trauner, Peter Quehenberger, Thomas Reiberger, Bernhard Scheiner, Mattias Mandorfer
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100934- (2024)
Background & Aims: Increased aggregation of individual platelets upon activation, as assessed by whole blood aggregometry standardised to platelet count (PLT), has recently been linked to progression of advanced chronic liver disease (ACLD). Moreover
Externí odkaz:
https://doaj.org/article/5cd4738087fd49dda7f345254ce5ce13
Autor:
Lukas Hartl, Benedikt Rumpf, Oliver Domenig, Benedikt Simbrunner, Rafael Paternostro, Mathias Jachs, Marko Poglitsch, Rodrig Marculescu, Michael Trauner, Roman Reindl-Schwaighofer, Manfred Hecking, Mattias Mandorfer, Thomas Reiberger
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract We aimed to assess the systemic and hepatic renin-angiotensin-system (RAS) fingerprint in advanced chronic liver disease (ACLD). This prospective study included 13 compensated (cACLD) and 12 decompensated ACLD (dACLD) patients undergoing hep
Externí odkaz:
https://doaj.org/article/1135ed85629041d8bc558fb1e8dafc54
Autor:
Benedikt S. Hofer, Benedikt Simbrunner, David J. M. Bauer, Rafael Paternostro, Philipp Schwabl, Bernhard Scheiner, Georg Semmler, Lukas Hartl, Mathias Jachs, Barbara Datterl, Albert F. Staettermayer, Michael Trauner, Mattias Mandorfer, Thomas Reiberger
Publikováno v:
Hepatology Communications, Vol 6, Iss 9, Pp 2569-2580 (2022)
Abstract Nonselective beta‐blockers are used as prophylaxis for variceal bleeding in patients with advanced chronic liver disease (ACLD). The acute hemodynamic response to intravenous propranolol (i.e., ≥10% reduction in hepatic venous pressure g
Externí odkaz:
https://doaj.org/article/8872b398c23a4c5d9378a84b5a9c5055
Autor:
Lorenz Balcar, Julia Krawanja, Bernhard Scheiner, Rafael Paternostro, Benedikt Simbrunner, Georg Semmler, Mathias Jachs, Lukas Hartl, Albert Friedrich Stättermayer, Philipp Schwabl, Matthias Pinter, Thomas Szekeres, Michael Trauner, Thomas Reiberger, Mattias Mandorfer
Publikováno v:
JHEP Reports, Vol 5, Iss 4, Pp 100682- (2023)
Background & Aims: Ammonia levels predicted hospitalisation in a recent landmark study not accounting for portal hypertension and systemic inflammation severity. We investigated (i) the prognostic value of venous ammonia levels (outcome cohort) for l
Externí odkaz:
https://doaj.org/article/b19f2478a3fd41be925cb5cd0689552f
Autor:
Wisse van Os, Beatrix Wulkersdorfer, Sabine Eberl, Zoe Oesterreicher, Philipp Schwabl, Thomas Reiberger, Rafael Paternostro, Maria Weber, Birgit Willinger, Markus Zeitlinger
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The environment of the infection site affects bacterial growth and antibiotic activity. When bacterial growth and antibiotic activity are studied in body fluids, samples of multiple subjects are usually pooled, averaging out potentially
Externí odkaz:
https://doaj.org/article/68d99fa6eac2496a9367b44e48d3a7eb
Autor:
Lorenz Balcar, Bernhard Scheiner, Markus Urheu, Patrick Weinberger, Rafael Paternostro, Benedikt Simbrunner, Lukas Hartl, Mathias Jachs, David Bauer, Georg Semmler, Claudia Willheim, Matthias Pinter, Peter Ferenci, Michael Trauner, Thomas Reiberger, Albert Friedrich Stättermayer, Mattias Mandorfer
Publikováno v:
JHEP Reports, Vol 4, Iss 11, Pp 100562- (2022)
Background & Aims: Alpha-1 antitrypsin (AAT) deficiency causes/predisposes individuals to advanced chronic liver disease (ACLD). However, the role of the SERPINA1 Pi∗Z allele in patients who have already progressed to ACLD is unclear. Thus, we aime
Externí odkaz:
https://doaj.org/article/7db32df2791c414bb06ecb495ca79f9a
Autor:
Tim Hendrikx, Florentina Porsch, Máté G. Kiss, Dragana Rajcic, Nikolina Papac-Miličević, Constanze Hoebinger, Laura Goederle, Anastasiya Hladik, Lisa E. Shaw, Hauke Horstmann, Sylvia Knapp, Sophia Derdak, Martin Bilban, Lena Heintz, Marcin Krawczyk, Rafael Paternostro, Michael Trauner, Matthias Farlik, Dennis Wolf, Christoph J. Binder
Publikováno v:
Journal of Hepatology, 77(5), 1373-1385. Elsevier Science
BACKGROUND & AIMS: Previous single-cell RNA-sequencing analyses have shown that Trem2-expressing macrophages are present in the liver during obesity, non-alcoholic steatohepatitis (NASH) and cirrhosis. Herein, we aimed to functionally characterize th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc35e9ab4202dfa69601804f0eecf88
https://doi.org/10.1016/j.jhep.2022.06.004
https://doi.org/10.1016/j.jhep.2022.06.004
Autor:
Benedikt Simbrunner, Ida Falk Villesen, Philipp Königshofer, Bernhard Scheiner, David Bauer, Rafael Paternostro, Philipp Schwabl, Gerald Timelthaler, Dariga Ramazanova, Katharina Wöran, Judith Stift, Ernst Eigenbauer, Albert Friedrich Stättermayer, Rodrig Marculescu, Matthias Pinter, Søren Møller, Michael Trauner, Morten Karsdal, Diana Julie Leeming, Thomas Reiberger, Mattias Mandorfer
Publikováno v:
Simbrunner, B, Villesen, I F, Königshofer, P, Scheiner, B, Bauer, D, Paternostro, R, Schwabl, P, Timelthaler, G, Ramazanova, D, Wöran, K, Stift, J, Eigenbauer, E, Stättermayer, AF, Marculescu, R, Pinter, M, Møller, S, Trauner, M, Karsdal, M, Leeming, D J, Reiberger, T & Mandorfer, M 2022, ' Systemic inflammation is linked to liver fibrogenesis in patients with advanced chronic liver disease ', Liver International, vol. 42, no. 11, pp. 2501-2512 . https://doi.org/10.1111/liv.15365
Background & Aims: Experimental evidence indicates that systemic inflammation (SI) promotes liver fibrogenesis. This study investigated the potential link between SI and fibrogenesis in patients with advanced chronic liver disease (ACLD). Methods: Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eea6c83cdc4a61490ad6b1020805c59
https://doi.org/10.1111/liv.15365
https://doi.org/10.1111/liv.15365
Autor:
Rafael Paternostro, Michael Trauner
Publikováno v:
Journal of Internal Medicine. 292:190-204
Non-alcoholic fatty liver disease (NAFLD) comprises a wide spectrum of pathologies ranging from non-alcoholic fatty liver (NAFL), characterized by simple steatosis without inflammation, to non-alcoholic steatohepatitis (NASH), characterized by steato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0e41f11b69f81bee961c4161177b3d
https://doi.org/10.1111/joim.13531
https://doi.org/10.1111/joim.13531
Autor:
Georg Semmler, Bernhard Scheiner, Philipp Schwabl, Theresa Bucsics, Rafael Paternostro, David Chromy, Albert Friedrich Stättermayer, Michael Trauner, Mattias Mandorfer, Arnulf Ferlitsch, Thomas Reiberger
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224506 (2019)
Background and aimsStudies in animal models have suggested that hepatic steatosis impacts on portal pressure, potentially by inducing liver sinusoidal endothelial dysfunction and thereby increasing intrahepatic resistance. Thus, we aimed to evaluate
Externí odkaz:
https://doaj.org/article/74e8f37ffaf04f3b91b5d7b1e2ad5403