Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Rafael Nesher"'
Autor:
Erol Cerasi, Avital Dov, Rafael Nesher, Eva Abramovitch, Marina Jmoudiak, Nasim Warwar, Ren Wu, Esther Haber
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783:1929-1934
Endocrine cells produce large amounts of one or more peptides. The post-translational control of selective production of a single protein is often unknown. We used 3 unrelated approaches to diminish PKCepsilon in rat islets to evaluate its role in pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b1e37326ad55ec3d2976f75e085858
https://doi.org/10.1016/j.bbamcr.2008.04.007
https://doi.org/10.1016/j.bbamcr.2008.04.007
Autor:
Barbara E. Corkey, Richard F. Corkey, Jude T. Deeney, Daphne Atlas, Rafael Nesher, Ann-Marie T. Richard, Michael Trus
Publikováno v:
Biochemistry. 46:14461-14467
L-type voltage-gated Ca 2+ channels (Cav1.2) mediate a major part of insulin secretion from pancreatic ‚-cells. Cav1.2, like other voltage-gated Ca 2+ channels, is functionally and physically coupled to synaptic proteins. The tight temporal couplin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cc93091365f447920e99c887b081d2
https://doi.org/10.1021/bi7016816
https://doi.org/10.1021/bi7016816
Publikováno v:
Endocrinology. 149:741-748
cAMP activates multiple signal pathways, crucial for the pancreatic β-cells function and survival and is a major potentiator of insulin release. A family of phosphodiesterases (PDEs) terminate the cAMP signals. We examined the expression of PDEs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7021bc2c941aef7b9467abc9f834f4
https://doi.org/10.1210/en.2007-0968
https://doi.org/10.1210/en.2007-0968
Publikováno v:
Diabetes. 55:590-599
Glucose metabolism affects most major signal pathways in pancreatic β-cells. Multiple protein kinases, including protein kinase C (PKC) isoenzymes, are involved in these effects; however, their role is poorly defined. Moreover, the dynamics of kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60d0e361dd81c9ed54c60ba743282476
https://doi.org/10.2337/diabetes.55.03.06.db05-0001
https://doi.org/10.2337/diabetes.55.03.06.db05-0001
Publikováno v:
British Journal of Pharmacology. 146:872-881
S 21403 (mitiglinide) is a new drug for type 2 diabetes mellitus (T2DM). Its action on insulin release and biosynthesis was investigated in several experimental systems utilizing pancreas from normal and T2DM animals. At high concentrations (10 μM),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f033cfc54c8256f0a89a629b6a4ad58e
https://doi.org/10.1038/sj.bjp.0706374
https://doi.org/10.1038/sj.bjp.0706374
Autor:
Rafael Nesher, Erol Cerasi
Publikováno v:
Diabetes. 51:S53-S59
The cellular and molecular mechanisms of insulin secretion are being intensively investigated, yet most researchers are seemingly unaware of the complexity of the dynamic regulation of the secretion. In this article, we summarize studies of the physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94758d46ab12d5652ce3651962d9c88d
https://doi.org/10.2337/diabetes.51.2007.s53
https://doi.org/10.2337/diabetes.51.2007.s53
Publikováno v:
Diabetes. 51:S68-S73
A full biphasic insulin response is the most sensitive index for well-coupled β-cell signal transduction. While first-phase insulin response is extremely sensitive to potentiating and inhibiting modulations, full expression of second-phase response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a1194ea2de8220ec1d4159604b208c
https://doi.org/10.2337/diabetes.51.2007.s68
https://doi.org/10.2337/diabetes.51.2007.s68
Publikováno v:
Diabetes. 48:731-737
The gerbil Psammomys obesus develops nutrition-dependent diabetes. We studied the interaction between diet and diabetic predisposition for beta-cell function. A 4-day high-energy (HE) diet induced a 3-, 4-, and 1.5-fold increase in serum glucose, ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607629280c2489400bd43fc507e7c9e1
https://doi.org/10.2337/diabetes.48.4.731
https://doi.org/10.2337/diabetes.48.4.731
Publikováno v:
Diabetes Research and Clinical Practice. 28:S27-S37
Both the insulin response to glucose and the sensitivity to insulin show large variation in the normal population. Many subjects have either a markedly low insulin response or low sensitivity to insulin, with nevertheless normal glucose tolerance. Fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8b66d826dccc49e7b2714e66f088d4
https://doi.org/10.1016/0168-8227(95)01083-p
https://doi.org/10.1016/0168-8227(95)01083-p
Publikováno v:
Journal of Pediatric Endocrinology and Metabolism. 22
Growth hormone (GH) reserve is defined biochemically by the peak serum concentration after stimulation with a known secretagogue. Arginine and clonidine stimulation tests are currently performed with 5 timed blood samples. We evaluated the diagnostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e200edabb7808dbc32a75c65cb3d15
https://doi.org/10.1515/jpem.2009.22.3.215
https://doi.org/10.1515/jpem.2009.22.3.215