Global Proteomic Profile of Aluminum-Induced Hippocampal Impairments in Rats: Are Low Doses of Aluminum Really Safe?

Autor: Leonardo Oliveira Bittencourt, Rakhel Dayanne Damasceno-Silva, Walessa Alana Bragança Aragão, Luciana Eiró-Quirino, Ana Carolina Alves Oliveira, Rafael Monteiro Fernandes, Marco Aurelio M. Freire, Sabrina Carvalho Cartágenes, Aline Dionizio, Marília Afonso Rabelo Buzalaf, Juliana Silva Cassoli, Ana Cirovic, Aleksandar Cirovic, Cristiane do Socorro Ferraz Maia, Rafael Rodrigues Lima

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12523
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Hippocampus is the brain area where aluminum (Al) accumulates in abundance and is widely associated with learning and memory. In the present study, we evaluate behavioral, tissue, and proteomic changes in the hippocampus of Wistar rats caused by expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8b7eab563ba0c6a294dd07a256d98c

Low doses of methylmercury exposure during adulthood in rats display oxidative stress, neurodegeneration in the motor cortex and lead to impairment of motor skills

Autor: Lílian Lund Amado, Maria Elena Crespo-Lopez, Francisco Bruno Teixeira, Luanna Melo Pereira Fernandes, Lygia Sega Nogueira, Priscila Cunha Nascimento, Rafael Rodrigues Lima, Luana Nazaré da Silva Santana, Cristiane Socorro Ferraz Maia, Rafael Monteiro Fernandes, Márcia Cristina Freitas da Silva, Leonardo Oliveira Bittencourt

Publikováno v: Journal of Trace Elements in Medicine and Biology. 51:19-27

Despite the vast distribution among tissues, the central nervous system (CNS) represents the main target of methylmercury (MeHg) toxicity. However, few studies have evaluated the effects of MeHg exposure on the CNS at equivalent doses to human enviro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0526a28e085f27476aaa7ebfbba6ef16
https://doi.org/10.1016/j.jtemb.2018.09.004

Contributors

Autor: Ebtesam A. Abdel-Shafy, Mosaad A. Abdel-Wahhab, Mohammad Abdollahi, Nour Hamid Abdurahman, Stephen Adeniyi Adefegha, Wale J. Adeyemi, Hizlan Hincal Agus, Quadri K. Alabi, Oluwaseun Ruth Alara, Dulce E. Alarcón Yaquetto, Doaa Abd Al-Hady, Sanaa A. Ali, Tariq Al-Talhi, María Olimpia Paz Alvarenga, Hanan F. Aly, Hatim Matuq M. Al-Yasi, Arturo Anadón, Walessa Alana Bragança Aragão, Irma Ares, M. Aylin Arici, Myriam Arriaga-Alba, Thilona Arumugam, Mehmet Nuri Atalar, Yasemin Aydin, Carlos Alberto Ayhllon-Osorio, Giuseppina Basta, Abdulhamit Battal, Leonardo Oliveira Bittencourt, İffet İpek Boşgelmez, Armando Butanda-Ochoa, Isa CAM, Esra Capanoglu, Gizem Catalkaya, Tiziana Cervelli, Fatma Duygu Ceylan, Victória dos Santos Chemelo, Yuguo Chen, Anil A. Chuturgoon, Dirleise Colle, Ana Carolina Oliveira Costa, Serena Del Turco, Abd El-Aziz A. Diab, Phiwayinkosi V. Dludla, Abdulahad Dogan, Luciana Guimarães Eiró, Ayşe Eken, Samy M. El-Megharbel, Aziza A. El-Nekeety, Melike Erkan, Marcelo Farina, Yibin Feng, Rafael Monteiro Fernandes, Maria Karolina Martins Ferreira, Roseane Fett, Evangelia Flampouri, Terisha Ghazi, Adil A. Gobouri, Luciano Valdemiro Gonzaga, Gustavo F. Gonzales, Karadayian Analía Graciela, Agnieszka Grzelak, Burcu Guldiken, Reham Z. Hamza, Qi Han, Shokoufeh Hassani, Reza Heidari, Rolando Hernández-Muñoz, Nabaweya A. Ibrahim, Mert Ilhan, Tejo J, Bustamante Juanita, Zine Kechrid, Mohamed Khiari, Fahima Klibet, Ural KOC, Melinda Kovács, Tomasz Kowalczyk, Duduku Krishnaiah, María Florencia Kronberg, Marcin Kruszewski, Leidiane Alencar de Oliveira Lima, Rafael Rodrigues Lima, M. Rocío López-Vargas, Johan Louw, Ali Akbar Malekirad, María Aránzazu Martínez, María Rosa Martínez-Larrañaga, Lamjed Marzouki, Sithandiwe E. Mazibuko-Mbeje, Jalil Mehrzad, Amel Saidi Merzouk, Hafida Merzouk, Miklós Mézes, Giza Hellen Nonato Miranda, Olorunfemi Raphael Molehin, Saeideh Momtaz, Regina Montero-Montoya, Eliana Rosa Munarriz, Vuyolwethu Mxinwa, Priscila Cunha Nascimento, Bongani B. Nkambule, Tawanda M. Nyambuya, Mohammad Mehdi Ommati, Patrick Orlando, Banu Orta Yilmaz, Gulay Ozkan, Jiaojiao Pang, Vinood B. Patel, Valeria M. Paz Aparicio, Victor R. Preedy, Bruna Puty, Rajkumar Rajendram, Nicholas V.C. Ralston, Laura J. Raymond, Jun Ren, Ariana Rossen, Kaïs Rtibi, Katrin Sak, Mayara Schulz, Hichem Sebai, Jose Ivan Serrano-Contreras, Naeem Sheik Abdul, Sonia Silvestri, Lores-Arnaiz Silvia, Przemysław Sitarek, Ewa Skała, Bogdan Gabriel Şlencu, Tomasz Śliwiński, Ruru Sun, András Szabó, Sylwia Terpilowska, Luca Tiano, Gabriela Torres-Santiago, Yesim Tuncok, Fikret Türkan, Ning Wang, Shuyi Wang, Changchang Xu, Feng Xu, Nebahat Yildizbayrak, L. Gerardo Zepeda-Vallejo, Cheng Zhang, Ying Zhang, Yue Zheng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98fceb72ccccfbedeec31416961222b3
https://doi.org/10.1016/b978-0-12-819092-0.09990-8

Evaluation of Cerebellar Function and Integrity of Adult Rats After Long-Term Exposure to Aluminum at Equivalent Urban Region Consumption Concentrations

Autor: Cristiane Socorro Ferraz Maia, Rafael Rodrigues Lima, Maria Karolina Ferreira Martins, Priscila Cunha Nascimento, Walessa Alana Bragança Aragão, Luis Felipe Sarmiento Rivera, Rafael Monteiro Fernandes, Leonardo Oliveira Bittencourt, Sabrina C. Cartágenes, Maria Elena Crespo-Lopez

Publikováno v: Biological trace element research. 199(4)

High amounts of aluminum (Al) are found in soil and water. It is highly bioavailable, which makes it an important agent of environmental imbalance. Moreover, Al is considered a neurotoxic agent that is associated with several neurodegenerative diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c7080777bc224114203a153f906f60
https://pubmed.ncbi.nlm.nih.gov/32564201

Preclinical evidences of aluminum-induced neurotoxicity in hippocampus and pre-frontal cortex of rats exposed to low doses

Autor: Luis Felipe Sarmiento, Rafael Monteiro Fernandes, Walessa Alana Bragança Aragão, Rafael Rodrigues Lima, Priscila Cunha Nascimento, Maria Elena Crespo-Lopez, Caroline Azulay Rodrigues, Cristiane Socorro Ferraz Maia, Marta Chagas Monteiro, Sabrina C. Cartágenes, Márcio Gonçalves Corrêa

Publikováno v: Ecotoxicology and Environmental Safety. 206:111139

Aluminum (Al) is a neurotoxicant agent implicated in several behavioral, neuropathological and neurochemical changes associated with cognitive impairments. Nevertheless, mechanisms of damage and safety concentrations are still very discussed. Thus, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33970f07f18d681a63211fba371618d5
https://doi.org/10.1016/j.ecoenv.2020.111139