Role of IP-10 to Predict Clinical Progression and Response to IL-6 Blockade With Sarilumab in Early COVID-19 Pneumonia. A Subanalysis of the SARICOR Clinical Trial

Autor: Marta Trigo-Rodríguez, Sheila Cárcel, Ana Navas, Reinaldo Espíndola-Gómez, José Carlos Garrido-Gracia, María Ángeles Esteban Moreno, Rafael León-López, Pedro María Martínez Pérez-Crespo, Eduardo Aguilar Alonso, David Vinuesa, Alberto Romero-Palacios, Inés Pérez-Camacho, Belén Gutiérrez-Gutiérrez, Francisco Javier Martínez-Marcos, Concepción Fernández-Roldán, Eva León, Alexandra Aceituno Caño, Juan E Corzo-Delgado, Elena Perez-Nadales, Cristina Riazzo, Carmen de la Fuente, Aurora Jurado, Julián Torre-Cisneros, Nicolás Merchante

Publikováno v: Open Forum Infectious Diseases. 10

Background The Clinical Trial of Sarilumab in Adults With COVID-19 (SARICOR) showed that patients with coronavirus disease 2019 (COVID-19) pneumonia and increased levels of interleukin (IL)-6 might benefit from blockade of the IL-6 pathway. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::632a1f67efef716ccdcfcaca5b0445dc
https://doi.org/10.1093/ofid/ofad133

Risk Factors for Multidrug-Resistant Gram-Negative Bacteria Carriage upon Admission to the Intensive Care Unit

Autor: Nicolás Francisco Fernández-Martínez, Sheila Cárcel-Fernández, Carmen De la Fuente-Martos, Rafael Ruiz-Montero, Bernardo R. Guzmán-Herrador, Rafael León-López, Francisco Javier Gómez, Julia Guzmán-Puche, Luis Martínez-Martínez, Inmaculada Salcedo-Leal

Publikováno v: International Journal of Environmental Research and Public Health; Volume 19; Issue 3; Pages: 1039
International Journal of Environmental Research and Public Health, Vol 19, Iss 1039, p 1039 (2022)
Digibug. Repositorio Institucional de la Universidad de Granada
instname

We gratefully acknowledge the collaboration of the Unit of Microbiology and the Maimonides Biomedical Research Institute of Cordoba (IMIBIC).
Multidrug-resistant Gram-negative bacteria (MDR-GNB) are microorganisms that have acquired resistance t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc56fb7351f2dc67739d0b39ab7a9d9
https://hdl.handle.net/10668/21018

Efficacy and safety of early treatment with sarilumab in hospitalised adults with COVID-19 presenting cytokine release syndrome (SARICOR STUDY): protocol of a phase II, open-label, randomised, multicentre, controlled clinical trial

Autor: Laura Perez, María Concepción Fernández-Roldán, Antonio Luque-Pineda, Julián Torre-Cisneros, M Ángeles Esteban-Moreno, Inés Pérez Camacho, Marta Santos, Alberto Romero Palacios, Rafael León López, Julián Olalla, Jesús Rodríguez-Baño, Nicolás Merchante, Eduardo Aguilar Alonso, Sheila Cárcel Fernández

Publikováno v: BMJ Open, Vol 10, Iss 11 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
BMJ Open

[Introduction] About 25% of patients with COVID-19 develop acute respiratory distress syndrome (ARDS) associated with a high release of pro-inflammatory cytokines such as interleukin-6 (IL-6). The aim of the SARICOR study is to demonstrate that early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0bbbf1f7dbaaec58e71590ad201cc9
https://bmjopen.bmj.com/content/10/11/e039951.full

Age-related injury patterns in Spanish trauma ICU patients. Results from the RETRAUCI

Autor: Lucía López-Amor, J. González-Robledo, Fermín Alberdi-Odriozola, Rubén Herrán-Monge, M. Chico-Fernández, María Dolores Mayor-García, F. Guerrero-López, M.Á. Ballesteros-Sanz, J.A. Llompart-Pou, A. Bueno-González, M. Sánchez-Casado, Rafael León-López

Publikováno v: Injury. 47:S61-S65

Background Injury patterns may differ in trauma patients when age is considered. This information is relevant in the management of trauma patients and for planning preventive measures. Methods We included in the study all patients admitted for trauma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a13fa220dc636a69c8b407a43d0eb3a
https://doi.org/10.1016/s0020-1383(16)30608-8

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Autor: Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andrés Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaïbi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarström, Nevin Hatipoğlu, Adem Karbuz, Sevgi Keles, Christèle Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarström, Rebeca Pérez de Diego, Laura Planas-Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Rivière, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlüter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M. Alsohime, Hagit Baris-Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, Yu-Lung Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-François Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, COVID Human Genetic Effort, COVIDeF Study Group, French COVID Cohort Study Group, CoV-Contact Cohort, COVID-STORM Clinicians, COVID Clinicians, Orchestra Working Group, Amsterdam UMC Covid-19 Biobank, NIAID-USUHS COVID Study Group, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D. Notarangelo, Stephanie Boisson-Dupuis, Helen C. Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, Aurélie Cobat

Publikováno v: Genome Medicine, Vol 15, Iss 1, Pp 1-25 (2023)

Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening

Externí odkaz: https://doaj.org/article/86e4db2aa39842caa8f2f5c9e6d95290