Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rafael K. Varaschin"'
Autor:
Gonzalo Sanchez, Rafael K Varaschin, Hansruedi Büeler, Paul C Marcogliese, David S Park, Louis-Eric Trudeau
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94826 (2014)
Parkinson's disease (PD) is one of the most prevalent neurodegenerative brain diseases; it is accompanied by extensive loss of dopamine (DA) neurons of the substantia nigra that project to the putamen, leading to impaired motor functions. Several gen
Externí odkaz:
https://doaj.org/article/338cbbc2bfbc4d46901edc1a04c733d1
Autor:
Sherdeep Singh, Rafael K. Varaschin, Paul W. Wiseman, Charles Ducrot, Nicolas Giguère, Guillaume Fortin, Consiglia Pacelli, Louis-Eric Trudeau, Willemieke M. Kouwenhoven, Marie-Josée Bourque, Marion Brill
Publikováno v:
The FASEB Journal. 33:400-417
Dopamine (DA) is a key regulator of circuits controlling movement and motivation. A subset of midbrain DA neurons has been shown to express the vesicular glutamate transporter (VGLUT)2, underlying their capacity for glutamate release. Glutamate relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d505bca63ae586fe50a9f618e60ea309
https://doi.org/10.1096/fj.201800713rr
https://doi.org/10.1096/fj.201800713rr
Autor:
Martina J. Rosenberg, Nyika A. Allen, Daniel D. Savage, Rafael K. Varaschin, C. Fernando Valenzuela
Publikováno v:
Alcoholism: Clinical and Experimental Research. 42:295-305
BACKGROUND We have reported that prenatal alcohol exposure (PAE)-induced deficits in dentate gyrus, long-term potentiation (LTP), and memory are ameliorated by the histamine H3 receptor inverse agonist ABT-239. Curiously, ABT-239 did not enhance LTP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82bdcf07fc216aa2a23b453d692e56fc
https://doi.org/10.1111/acer.13574
https://doi.org/10.1111/acer.13574
Autor:
John C. Roder, Ping Su, Rafael K. Varaschin, Albert H.C. Wong, Bernard Le Foll, Louis-Eric Trudeau, Caleb J. Browne, Fang Liu, Enoch Ng, Olaf Pongs, Joanna Hermainski
Publikováno v:
Behavioural Brain Research. 301:213-225
Calcium sensors detect intracellular calcium changes and interact with downstream targets to regulate many functions. Neuronal Calcium Sensor-1 (NCS-1) or Frequenin is widely expressed in the nervous system, and involved in neurotransmission, synapti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad706d5bd9cef24cde1569c190d9f3f
https://doi.org/10.1016/j.bbr.2015.12.037
https://doi.org/10.1016/j.bbr.2015.12.037
Autor:
Sakari Leino, Outi Salminen, Louis-Eric Trudeau, Charles Ducrot, Saara Rannanpää, Marie-Josée Bourque, Vania F. Prado, Marco A. M. Prado, Rafael K. Varaschin, Guillaume Osterstock
Publikováno v:
Anatomy and Cell Biology Publications
Histamine H-3 receptors are widely distributed Gi-coupled receptors whose activation reduces neuronal activity and inhibits release of numerous neurotransmitters. Although these receptors are abundantly expressed in the striatum, their modulatory rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f346eff8208a4b9357021d3116a9b5d
http://hdl.handle.net/10138/308732
http://hdl.handle.net/10138/308732
Autor:
Rafael K, Varaschin, Nyika A, Allen, Martina J, Rosenberg, C Fernando, Valenzuela, Daniel D, Savage
Publikováno v:
Alcoholism, clinical and experimental research. 42(2)
We have reported that prenatal alcohol exposure (PAE)-induced deficits in dentate gyrus, long-term potentiation (LTP), and memory are ameliorated by the histamine HLong-Evans rat dams voluntarily consumed either a 0% or 5% ethanol solution 4 hours ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::976bf6933f79cf6a6f4a0cf23aa29284
https://pubmed.ncbi.nlm.nih.gov/29315624
https://pubmed.ncbi.nlm.nih.gov/29315624
Publikováno v:
Alcoholism: Clinical and Experimental Research. 38:1902-1911
Background We previously reported that prenatal alcohol-induced deficits in dentate gyrus (DG) long-term potentiation (LTP) are ameliorated by the histamine H3 receptor inverse agonist ABT-239. ABT-239 did not enhance LTP in control rats, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7532c0de05c3a243dd396b6cec12a24e
https://doi.org/10.1111/acer.12430
https://doi.org/10.1111/acer.12430
Autor:
Derek A. Hamilton, Christina Wolff, Miranda C. Staples, Rafael K. Varaschin, Jessica L. Seidel, Daniel D. Savage, Kevin K. Caldwell, Martina J. Rosenberg, Carrie Wright, Katherine G. Akers, Ahmed El-Emawy
Publikováno v:
Alcoholism: Clinical and Experimental Research. 34:1793-1802
Drinking during pregnancy has been associated with long-lasting intellectual impairments in affected children (Hamilton et al., 2003; Hanson et al., 1978; Kodituwakku, 2009; Manji et al., 2009; Shaywitz et al., 1980; Streissguth et al., 1990; ) and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b31fee0cf7a997c097c24fcec485446a
https://doi.org/10.1111/j.1530-0277.2010.01266.x
https://doi.org/10.1111/j.1530-0277.2010.01266.x
Autor:
Martina J. Rosenberg, Rafael K. Varaschin, Derek A. Hamilton, Katherine G. Akers, Daniel D. Savage
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:191-198
Prenatal ethanol exposure causes deficits in hippocampal synaptic plasticity and learning. At present, there are no clinically effective pharmacotherapeutic interventions for these deficits. In this study, we examined whether the cognition-enhancing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fa87d8ab31ea4d49228045bdf8e3e3
https://doi.org/10.1124/jpet.109.165027
https://doi.org/10.1124/jpet.109.165027
Publikováno v:
Psychopharmacology. 206:85-96
Previous findings have shown that intra-accumbens injection of naltrexone, a non-selective opioid antagonist, blocks the acquisition of rapid tolerance to ethanol in rats. This study investigates the effects of intra-accumbens injection of the select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6592fc8f028b22007fc8d142ded920e1
https://doi.org/10.1007/s00213-009-1582-8
https://doi.org/10.1007/s00213-009-1582-8