Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rafael J Najmanovich"'
Autor:
Carlos A Rodríguez-Salazar, Sarah van Tol, Olivier Mailhot, Maria Gonzalez-Orozco, Gabriel T Galdino, Abbey N Warren, Natalia Teruel, Padmanava Behera, Kazi Sabrina Afreen, Lihong Zhang, Terry L Juelich, Jennifer K Smith, María Inés Zylber, Alexander N Freiberg, Rafael J Najmanovich, Maria I Giraldo, Ricardo Rajsbaum
Publikováno v:
PLoS Biology, Vol 22, Iss 2, p e3002544 (2024)
Ebolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase complex, which includes the cofactor and Interferon antagonist VP35. We p
Externí odkaz:
https://doaj.org/article/99a4e0e8910746299e1402b8c51819c3
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010777 (2022)
The Elastic Network Contact Model (ENCoM) is a coarse-grained normal mode analysis (NMA) model unique in its all-atom sensitivity to the sequence of the studied macromolecule and thus to the effect of mutations. We adapted ENCoM to simulate the dynam
Externí odkaz:
https://doaj.org/article/cbe7ebaef9084d8bb863e2b237ab69ff
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009286 (2021)
The SARS-CoV-2 Spike protein needs to be in an open-state conformation to interact with ACE2 to initiate viral entry. We utilise coarse-grained normal mode analysis to model the dynamics of Spike and calculate transition probabilities between states
Externí odkaz:
https://doaj.org/article/8d83078b6d3d4c518b26ee6537a0c4cb
Autor:
Vincent Frappier, Rafael J Najmanovich
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 4, p e1003569 (2014)
Normal mode analysis (NMA) methods are widely used to study dynamic aspects of protein structures. Two critical components of NMA methods are coarse-graining in the level of simplification used to represent protein structures and the choice of potent
Externí odkaz:
https://doaj.org/article/033ae2d5bb2241dbb2053e8725f9c440
Autor:
Jean-Pierre Sehi Glouzon, François Bolduc, Shengrui Wang, Rafael J Najmanovich, Jean-Pierre Perreault
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87297 (2014)
Viroids are small circular single-stranded infectious RNAs characterized by a relatively high mutation level. Knowledge of their sequence heterogeneity remains largely elusive and previous studies, using Sanger sequencing, were based on a limited num
Externí odkaz:
https://doaj.org/article/ea6d91d9267e4a2fad15b0c3a131ed08
Publikováno v:
Journal of Chemical Information & Modeling; Jul2015, Vol. 55 Issue 7, p1323-1336, 14p
Autor:
Rafael J. Najmanovich, Abdellah Allali-Hassani, Richard J. Morris, Ludmila Dombrovsky, Patricia W. Pan, Masoud Vedadi, Alexander N. Plotnikov, Aled Edwards, Cheryl Arrowsmith, Janet M. Thornton
Publikováno v:
Bioinformatics; Jan2007, Vol. 23 Issue 2, pe104-e109, 6p
Publikováno v:
BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background Promiscuity in molecular interactions between small-molecules, including drugs, and proteins is widespread. Such unintended interactions can be exploited to suggest drug repurposing possibilities as well as to identify potential m
Externí odkaz:
https://doaj.org/article/3125ccf8fa014d178b95490a3345f060
Publikováno v:
BioTechniques, Vol 38, Iss 6, Pp 847-851 (2005)
Externí odkaz:
https://doaj.org/article/26f8bfcaca654b8d83e1667509313d1f