Interactions of the male contraceptive target EPPIN with semenogelin-1 and small organic ligands

Autor: Antoniel A. S. Gomes, Natália C. M. Santos, Leonardo R. Rosa, Rafael J. Borges, Marcos R. M. Fontes, Katherine G. Hamil, Michael G. O’Rand, Erick J. R. Silva

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Novel male contraceptives will promote gender equality in sharing contraceptive responsibility. The sperm-associated protein epididymal protease inhibitor (EPPIN) is a promising target for non-hormonal male contraception. EPPIN interacts wit

Externí odkaz: https://doaj.org/article/823afa632081474b9071c261e38fb539

Structural and functional studies of a snake venom phospholipase A2-like protein complexed to an inhibitor from Tabernaemontana catharinensis

Autor: Rafael J. Borges, Fábio F. Cardoso, Cicilia de Carvalho, Ivan de Marino, Paulo S. Pereira, Andreimar M. Soares, Maeli Dal-Pai-Silva, Isabel Usón, Marcos R.M. Fontes

Publikováno v: Biochimie. 206:105-115

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78fa53977bff7566b0fbf5f6197770eb
https://doi.org/10.1016/j.biochi.2022.10.011

Structural and functional studies of a snake venom phospholipase A

Autor: Rafael J, Borges, Fábio F, Cardoso, Cicilia, de Carvalho, Ivan, de Marino, Paulo S, Pereira, Andreimar M, Soares, Maeli, Dal-Pai-Silva, Isabel, Usón, Marcos R M, Fontes

Publikováno v: Biochimie.

Snake envenomation is an ongoing global health problem and tropical neglected disease that afflicts millions of people each year. The only specific treatment, antivenom, has several limitations that affects its proper distribution to the victims and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::370d39d8955a11fe7805f06717b330a3
https://pubmed.ncbi.nlm.nih.gov/36273763

Fragment-based ab initio phasing of peptidic nanocrystals by MicroED

Autor: Logan S. Richards, Rafael J. Borges, Jose A. Rodriguez, Calina Glynn, Marcus Gallagher-Jones, Chih-Te Zee, Claudia Millán, Maria D. Flores, Michael R. Sawaya, Isabel Usón

Microcrystal electron diffraction (MicroED) is transforming the visualization of molecules from nanocrystals, rendering their three-dimensional atomic structures from previously unamenable samples. Peptidic structures determined by MicroED include na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74fed878855908af4f3f9369c1960adb
https://doi.org/10.1101/2021.09.13.459692

The synthetic varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins

Autor: Marcos R.M. Fontes, Bruno Lomonte, Rafael J. Borges, Guilherme H. M. Salvador, Matthew R. Lewin

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Biochimica et Biophysica Acta, vol.1865(7), pp.1-11
Kérwá
Universidad de Costa Rica
instacron:UCR

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d02d8d8316a305d4aeacf44bca5f130