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pro vyhledávání: '"Rafael Filippelli da Silva"'
Autor:
Rafael Filippelli da Silva, Paola Bianchi Guimarães, Clovis R. Nakaie, João Bosco Pesquero, Jair R. Chagas, Liliam Fernandes, Adriana K. Carmona, Michael Bader, Carolina Caldas Hoff
Publikováno v:
Inflammation Research. 68:845-855
Carboxypeptidase M (CPM) is a glycosylphosphatidylinositol anchored enzyme that plays an important role in the kallikrein–kinin system (KKS). CPM catalytic domain hydrolyzes Arg from C-terminal peptides (i.e., bradykinin and kallidin), generating d
Autor:
Suma I. Shimuta, Laerte Oliveira, Clovis R. Nakaie, Eliete S. Rodrigues, Renan Paulo Martin, Rafael Filippelli da Silva
Publikováno v:
Regulatory peptides. 181
Mutant forms of kinin B(1) receptor (B(1)R) and analogs of the full agonist des-Arg(9)-bradykinin (DABK) were investigated aiming to verify the importance of selected receptor residues and of each agonist-peptide residue in the specific binding and a
Autor:
Michael Bader, Suma I. Shimuta, Rafael Filippelli da Silva, Clovis R. Nakaie, Regiane A. Sabatini, Renan Paulo Martin, Eliete S. Rodrigues, Vanessa F. Merino, João Bosco Pesquero, Suzana M. Oliveira
Publikováno v:
Peptides. 42
Bradykinin (BK) and des-Arg 9 -bradykinin (DBK) of kallikrein-kinin system exert its effects mediated by the B 2 (B 2 R) and B 1 (B 1 R) receptors, respectively. It was already shown that the deletion of kinin B 1 R or of B 2 R induces upregulation o