Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Rafael Dariolli"'
Autor:
Juan J. A. M. Muñoz, Rafael Dariolli, Caio Mateus da Silva, Elida A. Neri, Iuri C. Valadão, Lauro Thiago Turaça, Vanessa M. Lima, Mariana Lombardi Peres de Carvalho, Mariliza R. Velho, Eric A. Sobie, Jose E. Krieger
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-27 (2022)
Abstract Background Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising disease model, even though hiPSC-CMs cultured for extended periods display an undifferentiated transcriptional landscape. MiRNA–target gene in
Externí odkaz:
https://doaj.org/article/b25de1df4cea49079927edc93026a79a
Autor:
Ruan F. V. Medrano, Thiago A. Salles, Rafael Dariolli, Fernanda Antunes, Valker A. Feitosa, Aline Hunger, João P. P. Catani, Samir A. Mendonça, Rodrigo E. Tamura, Marlous G. Lana, Elaine G. Rodrigues, Bryan E. Strauss
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Balancing safety and efficacy is a major consideration for cancer treatments, especially when combining cancer immunotherapy with other treatment modalities such as chemotherapy. Approaches that induce immunogenic cell death (ICD) are expect
Externí odkaz:
https://doaj.org/article/4e303cb2b2404512bca7554bb2e8650b
Autor:
Jaehee V. Shim, Yuguang Xiong, Priyanka Dhanan, Rafael Dariolli, Evren U. Azeloglu, Bin Hu, Gomathi Jayaraman, Christoph Schaniel, Marc R. Birtwistle, Ravi Iyengar, Nicole C. Dubois, Eric A. Sobie
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Tyrosine kinase inhibitor drugs (TKIs) are highly effective cancer drugs, yet many TKIs are associated with various forms of cardiotoxicity. The mechanisms underlying these drug-induced adverse events remain poorly understood. We studie
Externí odkaz:
https://doaj.org/article/34cb91a0713c46fcaf185758eb2db0c2
Autor:
Chrystian Junqueira Alves, Rafael Dariolli, Jonathan Haydak, Sangjo Kang, Theodore Hannah, Robert J. Wiener, Stefanie DeFronzo, Rut Tejero, Gabriele L. Gusella, Aarthi Ramakrishnan, Rodrigo Alves Dias, Alexandre Wojcinski, Santosh Kesari, Li Shen, Eric A. Sobie, José Paulo Rodrigues Furtado de Mendonça, Evren U. Azeloglu, Hongyan Zou, Roland H. Friedel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Biomechanical mechanisms orchestrating stem cell dynamics in development remain unclear. Here the authors show that guidance receptor Plexin-B2 organizes actomyosin contractility, cytoskeletal tension and adhesion during multicellular development of
Externí odkaz:
https://doaj.org/article/ec4433536a404ae78838f90b72c22b29
Autor:
Meera Varshneya, Itziar Irurzun-Arana, Chiara Campana, Rafael Dariolli, Amy Gutierrez, Taylor K. Pullinger, Eric A. Sobie
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 100-107 (2021)
Many drugs that have been proposed for treatment of coronavirus disease 2019 (COVID‐19) are reported to cause cardiac adverse events, including ventricular arrhythmias. In order to properly weigh risks against potential benefits, particularly when
Externí odkaz:
https://doaj.org/article/7e128337b2e345fdb76274f4167301cb
Autor:
José Alexandre Salerno, Thayana Torquato, Jairo R. Temerozo, Livia Goto-Silva, Karina Karmirian, Mayara A. Mendes, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Letícia R Q. Souza, Isis M. Ornelas, Carla P. Veríssimo, Luiz Guilherme H S. Aragão, Gabriela Vitória, Carolina S G. Pedrosa, Suelen da Silva Gomes Dias, Vinicius Cardoso Soares, Teresa Puig-Pijuan, Vinícius Salazar, Rafael Dariolli, Diogo Biagi, Daniel R. Furtado, Luciana Barreto Chiarini, Helena L. Borges, Patrícia T. Bozza, Marilia Zaluar P. Guimarães, Thiago M.L. Souza, Stevens K. Rehen
Publikováno v:
PeerJ, Vol 9, p e12595 (2021)
SARS-CoV-2 infects cardiac cells and causes heart dysfunction. Conditions such as myocarditis and arrhythmia have been reported in COVID-19 patients. The Sigma-1 receptor (S1R) is a ubiquitously expressed chaperone that plays a central role in cardio
Externí odkaz:
https://doaj.org/article/654771cd45c94c0ebd7a55057203f3db
Autor:
Luiz Guilherme H. S. Aragão, Júlia T. Oliveira, Jairo R. Temerozo, Mayara A. Mendes, José Alexandre Salerno, Carolina S. G. Pedrosa, Teresa Puig-Pijuan, Carla P. Veríssimo, Isis M. Ornelas, Thayana Torquato, Gabriela Vitória, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Suelen da Silva Gomes Dias, Vinicius Cardoso Soares, Letícia R. Q. Souza, Karina Karmirian, Livia Goto-Silva, Diogo Biagi, Estela M. Cruvinel, Rafael Dariolli, Daniel R. Furtado, Patrícia T. Bozza, Helena L. Borges, Thiago M. L. Souza, Marília Zaluar P. Guimarães, Stevens K. Rehen
Publikováno v:
PeerJ, Vol 9, p e12262 (2021)
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can infect several organs, especially impacting respiratory capacity. Among the extrapulmonary manifestations of COVID-19 is myocardi
Externí odkaz:
https://doaj.org/article/ce3f2fb7034a4198b040ce2921144372
Autor:
Carolina da S.G. Pedrosa, Livia Goto-Silva, Jairo R. Temerozo, Leticia R.Q. Souza, Gabriela Vitória, Isis M. Ornelas, Karina Karmirian, Mayara A. Mendes, Ismael C. Gomes, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Vinicius Cardoso Soares, Suelen da Silva Gomes Dias, José A. Salerno, Teresa Puig-Pijuan, Julia T. Oliveira, Luiz G.H.S. Aragão, Thayana C.Q. Torquato, Carla Veríssimo, Diogo Biagi, Estela M. Cruvinel, Rafael Dariolli, Daniel R. Furtado, Helena L. Borges, Patrícia T. Bozza, Stevens Rehen, Thiago Moreno L. Souza, Marília Zaluar P. Guimarães
Publikováno v:
Stem Cell Research, Vol 54, Iss , Pp 102436- (2021)
Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis
Externí odkaz:
https://doaj.org/article/ab1ba8301e984f0faf1cf30367661855
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Numerous commonly prescribed drugs, including antiarrhythmics, antihistamines, and antibiotics, carry a proarrhythmic risk and may induce dangerous arrhythmias, including the potentially fatal Torsades de Pointes. For this reason, cardiotoxicity test
Externí odkaz:
https://doaj.org/article/e9b9595bf316408e8b449ae098564d19
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The rapid dissemination of SARS-CoV-2 has made COVID-19 a tremendous social, economic, and health burden. Despite the efforts to understand the virus and treat the disease, many questions remain unanswered about COVID-19 mechanisms of infection and p
Externí odkaz:
https://doaj.org/article/416fef63149e4ff39b5d953af8faaacc