Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Rafael Contreras-Galindo"'
Autor:
Souren Paul, Mark H. Kaplan, Dinesh Khanna, Preston M. McCourt, Anjan K. Saha, Pei-Suen Tsou, Mahek Anand, Alexander Radecki, Mohamad Mourad, Amr H. Sawalha, David M. Markovitz, Rafael Contreras-Galindo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Fibrosis of the skin plays an important role in scleroderma. Here the authors demonstrate genetic and epigenetic abnormalities at the centromere that affect the replication of the chromosomes, resulting in activation of pathways involved in inflammat
Externí odkaz:
https://doaj.org/article/d5eaf6cdd6504e8d8ebc8070af2ffb48
Autor:
Mark H. Kaplan, Rafael Contreras-Galindo, Evelyn Jiagge, Sofia D. Merajver, Lisa Newman, Galya Bigman, Michael H. Dosik, Ganesh S. Palapattu, Javed Siddiqui, Arul M. Chinnaiyan, Sally Adebamowo, Clement Adebamowo
Publikováno v:
Infectious Agents and Cancer, Vol 15, Iss 1, Pp 1-15 (2020)
Abstract The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). A HERV-K HML-2 fully intact provirus Xq21.33 was recently identified in some West African people. We used PCR technology to se
Externí odkaz:
https://doaj.org/article/91f29a5b675b4bf4a266d275ede02f19
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9313 (2022)
Robust, tightly regulated DNA repair is critical to maintaining genome stability and preventing cancer. Eukaryotic DNA is packaged into chromatin, which has a profound, yet incompletely understood, regulatory influence on DNA repair and genome stabil
Externí odkaz:
https://doaj.org/article/39a3d963885f44918f0aa0b4af8e749d
Autor:
Mark H. Kaplan, Mark Kaminski, Judith M. Estes, Scott D. Gitlin, Joseph Zahn, James T. Elder, Trilokraj Tejasvi, Elizabeth Gensterblum, Amr H. Sawalha, Joseph Patrick McGowan, Michael H. Dosik, Haner Direskeneli, Guher Saruhan Direskeneli, Sally N. Adebamowo, Clement A. Adebamowo, Mohammad Sajadi, Rafael Contreras-Galindo
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-18 (2019)
Abstract Background Human Endogenous Retroviruses type K HML-2 (HK2) are integrated into 117 or more areas of human chromosomal arms while two newly discovered HK2 proviruses, K111 and K222, spread extensively in pericentromeric regions, are the firs
Externí odkaz:
https://doaj.org/article/66f9263a639348f29d3f0aa69955e37f
Autor:
Susana M Chan, Tamar Sapir, Sung-Soo Park, Jean-François Rual, Rafael Contreras-Galindo, Orly Reiner, David M Markovitz
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212970 (2019)
Human endogenous retroviruses are remnants of ancient germline infections that make up approximately 8% of the modern human genome. The HERV-K (HML-2) family is one of the most recent entrants into the human germline, these viruses appear to be trans
Externí odkaz:
https://doaj.org/article/1ce94090caf74aac93896172cbee83c5
Autor:
SOUREN PAUL, Preston McCourt, Le Thi My Le, Joohyun Ryu, Wioletta Czaja, Ann Bode, Rafael Contreras-Galindo, zigang Dong
Telomeres protect chromosome ends and determine the proliferative potential of cells. The canonical telomere sequence TTAGGG is synthesized by telomerase holoenzyme, which maintains telomere length in proliferative stem cells. Although the core compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a0b77da5f7cd690a4ebcaa55cf1ec9e
https://doi.org/10.21203/rs.3.rs-1425640/v1
https://doi.org/10.21203/rs.3.rs-1425640/v1
Autor:
Yashar S. Niknafs, Monica Palande, Karthik R. Padmanabhan, Matthew K. Iyer, Gilbert S. Omenn, Tingting Qin, Anjan K. Saha, Tara Tang, Maureen A. Sartor, Brian Qian, Scott D. Gitlin, David M. Markovitz, Elizabeth A. Ward, Rafael Contreras-Galindo, Arul M. Chinnaiyan, Javed Siddiqui, Claire L. Wang, Scott A. Tomlins
Publikováno v:
The Journal of Biological Chemistry
Overexpression of centromeric proteins has been identified in a number of human malignancies, but the functional and mechanistic contributions of these proteins to disease progression have not been characterized. The centromeric histone H3 variant ce
Autor:
Sofia D. Merajver, Javed Siddiqui, Michael H. Dosik, Lisa A. Newman, Galya Bigman, Ganesh S. Palapattu, Rafael Contreras-Galindo, Clement Adebamowo, Mark H. Kaplan, Arul M. Chinnaiyan, Evelyn Jiagge, Sally N. Adebamowo
Publikováno v:
Infectious Agents and Cancer, Vol 15, Iss 1, Pp 1-15 (2020)
Infectious Agents and Cancer
Infectious Agents and Cancer
The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). A HERV-K HML-2 fully intact provirus Xq21.33 was recently identified in some West African people. We used PCR technology to search for
Autor:
Maureen A. Sartor, Rafael Contreras-Galindo, Haihong Guo, Christopher T Lee, David M. Markovitz, Hal E. Broxmeyer, Maureen Legendre, Nirit Mor-Vaknin, Scott Cooper, Xinxin Huang, Maegan L. Capitano, Anjan K. Saha, Ferdinand Kappes
Publikováno v:
Journal of Clinical Investigation. 129:2555-2570
The nuclear protein DEK is an endogenous DNA-binding chromatin factor regulating hematopoiesis. DEK is one of only 2 known secreted nuclear chromatin factors, but whether and how extracellular DEK regulates hematopoiesis is not known. We demonstrated
Autor:
Joseph Zahn, Sally N. Adebamowo, Amr H. Sawalha, James T. Elder, Rafael Contreras-Galindo, Judith Estes, Mohammad M. Sajadi, Elizabeth Gensterblum, Haner Direskeneli, Mark S. Kaminski, Mark H. Kaplan, Scott D. Gitlin, Clement Adebamowo, Michael H. Dosik, Trilokraj Tejasvi, Guher Saruhan Direskeneli, Joseph P. McGowan
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-18 (2019)
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-18 (2019)
Background Human Endogenous Retroviruses type K HML-2 (HK2) are integrated into 117 or more areas of human chromosomal arms while two newly discovered HK2 proviruses, K111 and K222, spread extensively in pericentromeric regions, are the first retrovi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943287848ec3502d9eee63c44aad4930
https://hdl.handle.net/11424/243994
https://hdl.handle.net/11424/243994