Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Rafael C Gaspar"'
Autor:
Brooks P Leitner, Won D Lee, Wanling Zhu, Xinyi Zhang, Rafael C Gaspar, Zongyu Li, Joshua D Rabinowitz, Rachel J Perry
Publikováno v:
PLoS ONE, Vol 18, Iss 7, p e0286525 (2023)
Reprogramming metabolism is of great therapeutic interest for reducing morbidity and mortality during sepsis-induced critical illness. Disappointing results from randomized controlled trials targeting glutamine and antioxidant metabolism in patients
Externí odkaz:
https://doaj.org/article/7025dcbc0b0b490abb9be4ddee4bb5fc
Autor:
Vitor R. Muñoz, Rafael C. Gaspar, Matheus B. Severino, Ana P. A. Macêdo, Fernando M. Simabuco, Eduardo R. Ropelle, Dennys E. Cintra, Adelino S. R. da Silva, Young-Bum Kim, José Rodrigo Pauli
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Physical exercise is considered a fundamental strategy in improving insulin sensitivity and glucose uptake in skeletal muscle. However, the molecular mechanisms underlying this regulation, primarily on skeletal muscle glucose uptake, are not fully un
Externí odkaz:
https://doaj.org/article/e425139095d144638760cc70c4c41a0e
Autor:
Rafael S. Brícola, André V. Cordeiro, Barbara M. Crisol, Renata R. Braga, Diego G. de Melo, Matheus B. Rocha, Rafael C. Gaspar, Susana C. B. R. Nakandakari, Vagner R. R. Silva, Chadi P. Anaruma, Carlos K. Katashima, Raphael D. S. Canciglieri, Vitor R. Munõz, Isadora C. B. Pavan, Ana P. Pinto, Fernando M. Simabuco, Adelino S. R. da Silva, Leandro P. Moura, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle
Publikováno v:
Cell Biochemistry and Function. 41:128-137
Dysfunction of the adipose tissue metabolism is considered as a significant hallmark of aging. It has been proposed that α-β hydrolase domain containing 5 (ABHD5) plays a critical role in the control of lipolysis. However, the role of ABHD5 in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7696e7cfd07d8d388a0429094ae19563
https://doi.org/10.1002/cbf.3770
https://doi.org/10.1002/cbf.3770
Autor:
Rafael C. Gaspar, Kun Lyu, Brandon T. Hubbard, Brooks P. Leitner, Panu K. Luukkonen, Sandro M. Hirabara, Ikki Sakuma, Ali Nasiri, Dongyan Zhang, Mario Kahn, Gary W. Cline, José Rodrigo Pauli, Rachel J. Perry, Kitt F. Petersen, Gerald I. Shulman
Publikováno v:
Diabetologia. 66:567-578
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b51039e9f4473f061216eb986b4a9854
https://doi.org/10.1007/s00125-022-05838-8
https://doi.org/10.1007/s00125-022-05838-8
Autor:
Panu K. Luukkonen, Ikki Sakuma, Rafael C. Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K. Penttilä, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Järvinen, Kitt Falk Petersen, Gerald I. Shulman
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, in which prognosis is determined by liver fibrosis. A common variant in hydroxysteroid 17-beta dehydrogenase 13 ( HSD17B13 , rs72613567-A) is associated with a reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e00c6a62d24933271105d69ddf57a566
https://doi.org/10.1073/pnas.2217543120
https://doi.org/10.1073/pnas.2217543120
Autor:
Brooks P. Leitner, Won D. Lee, Wanling Zhu, Xinyi Zhang, Rafael C. Gaspar, Zongyu Li, Joshua D. Rabinowitz, Rachel J. Perry
SummaryReprogramming metabolism is of great therapeutic interest for reducing morbidity and mortality during sepsis-induced critical illness1. Disappointing results from randomized controlled trials targeting glutamine and antioxidant metabolism in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60a17c6416a1bf8caa4a094b155ea40d
https://doi.org/10.1101/2022.10.08.511411
https://doi.org/10.1101/2022.10.08.511411
Autor:
Bárbara de A. Rodrigues, Vitor R. Muñoz, Gabriel K. Kuga, Rafael C. Gaspar, Susana C. B. R. Nakandakari, Barbara M. Crisol, José D. Botezelli, Luciana S. S. Pauli, Adelino S. R. da Silva, Leandro P. de Moura, Dennys E. Cintra, Eduardo R. Ropelle, José R. Pauli
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Mitogen-activated Protein Kinase Phosphatase 3 (MKP-3) has been involved in the negative regulation of insulin signaling. The absence of MKP-3 is also associated with reduced adiposity, increased energy expenditure and improved insulin sensitivity. T
Externí odkaz:
https://doaj.org/article/755f79ce77b44acaa6aafc18aa222bde
Autor:
xinyi zhang, Won D. Lee, Brooks P. Leitner, Wanling Zhu, Zongyu Li, Rafael C. Gaspar, Alexandra A. Halberstam, Briana Robles, Joshua D. Rabinowitz, Rachel J. Perry
Publikováno v:
Cancer Research. 83:285-285
In this study, we identified a potential practice-changing approach, dichloroacetate (DCA), to harness metabolic adjuvant therapy to treat cancer-related fatigue (CRF). CRF is one of the most common complications in patients with multiple cancer type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e16b21485611be22335d677bce19c9e
https://doi.org/10.1158/1538-7445.am2023-285
https://doi.org/10.1158/1538-7445.am2023-285
Autor:
Traci E. LaMoia, Gina M. Butrico, Hasini A. Kalpage, Leigh Goedeke, Brandon T. Hubbard, Daniel F. Vatner, Rafael C. Gaspar, Xian-Man Zhang, Gary W. Cline, Keita Nakahara, Seungwan Woo, Atsuhiro Shimada, Maik Hüttemann, Gerald I. Shulman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(10)
Significance Metformin is the most commonly prescribed drug for the treatment of type 2 diabetes mellitus, yet the mechanism by which it lowers plasma glucose concentrations has remained elusive. Most studies to date have attributed metformin’s glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7c662630fa8270a808777b7ba425f4
https://pubmed.ncbi.nlm.nih.gov/35238637
https://pubmed.ncbi.nlm.nih.gov/35238637
Autor:
Brandon T. Hubbard, Traci E. LaMoia, Leigh Goedeke, Rafael C. Gaspar, Katrine D. Galsgaard, Mario Kahn, Graeme F. Mason, Gerald I. Shulman
Publikováno v:
Cell Metabolism. 35:212-226.e4
The mammalian succinate dehydrogenase (SDH) complex has recently been shown as capable of operating bidirectionally. Here, we develop a method (Q-Flux) capable of measuring absolute rates of both forward (V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6f72c85c42b65381332fe732e21e97
https://doi.org/10.1016/j.cmet.2022.11.011
https://doi.org/10.1016/j.cmet.2022.11.011