Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rafael B. Polidoro"'
Autor:
Maria Gutierrez-Arcelus, Nikola Teslovich, Alex R. Mola, Rafael B. Polidoro, Aparna Nathan, Hyun Kim, Susan Hannes, Kamil Slowikowski, Gerald F. M. Watts, Ilya Korsunsky, Michael B. Brenner, Soumya Raychaudhuri, Patrick J. Brennan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Innate T cells (ITC) contain many subsets and are poised to promptly respond to antigens and pathogens, but how this poised state is maintained is still unclear. Here the authors perform single-cell RNA-seq to align the various ITC subsets along an
Externí odkaz:
https://doaj.org/article/2c456f6c872247e0aaea1df612dd18ae
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some patients, lung infection leads to the activation of alveolar macrophages and lung epithelial cells that will release proinflammatory cytokines. IL-6, TNF, and IL-1β in
Externí odkaz:
https://doaj.org/article/01070f1eb3d64ab7a5aa94a5881b50d8
Autor:
Ricardo T. Gazzinelli, Jeffrey D. Dvorin, Judy Lieberman, Rafael B. Polidoro, Ângela C. Crespo, Sumit Sen Santara, Zhitao Liang, Dhelio Batista Pereira, Caroline Junqueira, Guilherme Castro, Sabrina Absalon
Publikováno v:
Nature immunology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Activated Vγ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are expanded in Plasmodium falciparum–infected patients. Although previous studies suggested that γδ2 T cells help control erythrocytic malaria, whether γδ2 T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2ac317932d52ba18a368ac0c36c968
http://europepmc.org/articles/PMC7906917
http://europepmc.org/articles/PMC7906917
Autor:
Yunlong Liu, Rafael B. Polidoro, Morgan Little, Stephen P. Hoffman, Kevin Bi, Hongyu Gao, D. Noah Sather, Laura C. Steinhardt, Leetah Senkpeil, Adrian L. Oblak, Nathan W. Schmidt, Edward Simpson, Tuan M. Tran, W. Nicholas Haining, Jyoti Bhardwaj, Erik L. Gaskin, Prasida Holla, Kathleen B. Yates, Xiaowen Liu, Aditi Upadhye, Kephas Otieno, Martina Oneko, Barbara J. Flynn, Robert A. Seder, Michael D. Macklin, Simon Kariuki, Ayako Yamamoto, Ryan E. Wiegand, Xiaoling Xuei, Phillip A. Swanson
Publikováno v:
SSRN Electronic Journal.
Baseline innate immune signatures can influence protective immunity following vaccination. Here, we used systems transcriptional analysis to assess the molecular mechanisms underlying differential immunogenicity and protective efficacy results of a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d1cbffa7fe5943593547829fd72828
https://doi.org/10.2139/ssrn.3946574
https://doi.org/10.2139/ssrn.3946574
Autor:
Patrick J. Brennan, Aparna Nathan, Susan K. Hannes, Alex R. Mola, Rafael B. Polidoro, Kamil Slowikowski, Gerald F. Watts, Soumya Raychaudhuri, Maria Gutierrez-Arcelus, Michael B. Brenner, Ilya Korsunsky, Nikola Teslovich, Hyun Wha Kim
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
How innate T cells (ITC), including invariant natural killer T (iNKT) cells, mucosal-associated invariant T (MAIT) cells, and γδ T cells, maintain a poised effector state has been unclear. Here we address this question using low-input and single-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfed280d1072447a1a9ab4d5bbc0f69d
https://doi.org/10.1038/s41467-019-08604-4
https://doi.org/10.1038/s41467-019-08604-4
Autor:
Ricardo T. Gazzinelli, Rafael B. Polidoro, Farokh Dotiwala, Judy Lieberman, Michael Walch, James Ansara, Sachin Mulik, Barbara A. Burleigh
Publikováno v:
Nat Med
Protozoan infections are a serious global health problem1, 2. Natural killer (NK) cells and cytolytic T lymphocytes (CTLs) eliminate pathogen-infected cells by releasing cytolytic granule contents—granzyme (Gzm) proteases and the pore-forming perfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1102c4b77cf3c4b0e8a187682aa650c5
https://doi.org/10.1038/nm.4023
https://doi.org/10.1038/nm.4023
Autor:
Patrick J. Brennan, Rafael B. Polidoro, Nora A. Barrett, Katherine L. Tuttle, Alex R. Mola, Daniel F. Dwyer, Joshua A. Boyce
Publikováno v:
Journal of Allergy and Clinical Immunology. 143:AB214
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c19485e1a6c838fbe29684def500332
https://doi.org/10.1016/j.jaci.2018.12.651
https://doi.org/10.1016/j.jaci.2018.12.651
Autor:
Natasha S. Barteneva, Barbara A. Burleigh, Ricardo T. Gazzinelli, Prasad K. Padmanabhan, Rafael B. Polidoro
Publikováno v:
Molecular and biochemical parasitology. 198(2)
The capacity for rapid localization of epitope-tagged or fluorescent fusion proteins in cells is an important tool for biological discovery and functional analysis. For Trypanosoma cruzi, the protozoan parasite that causes human Chagas disease, visua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eafa410e52e4e386c707ae2dc488ac5
https://pubmed.ncbi.nlm.nih.gov/25712770
https://pubmed.ncbi.nlm.nih.gov/25712770
Autor:
Lirlândia P. Sousa, Rafael B. Polidoro, Mauro M. Teixeira, Alexandre V. Machado, Ana Paula C. Salgado, Caio T. Fagundes, Cristiana C. Garcia, Remo Castro Russo, Rodrigo Guabiraba, Luciana P. Tavares, Geovanni Dantas Cassali
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2010, 6 (11), pp.1-16. ⟨10.1371/journal.ppat.1001171⟩
PLoS Pathogens, Vol 6, Iss 11, p e1001171 (2010)
Plos Pathogens 11 (6), 1-16. (2010)
PLoS Pathogens, Public Library of Science, 2010, 6 (11), pp.1-16. ⟨10.1371/journal.ppat.1001171⟩
PLoS Pathogens, Vol 6, Iss 11, p e1001171 (2010)
Plos Pathogens 11 (6), 1-16. (2010)
Influenza A virus causes annual epidemics which affect millions of people worldwide. A recent Influenza pandemic brought new awareness over the health impact of the disease. It is thought that a severe inflammatory response against the virus contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ecdc5be8ab8c26f76a9f30b56dfa12
https://hal.inrae.fr/hal-02660382/document
https://hal.inrae.fr/hal-02660382/document
Autor:
A Trey Belew, Caroline Junqueira, Gabriela F Rodrigues-Luiz, Bruna M Valente, Antonio Edson R Oliveira, Rafael B Polidoro, Luciana W Zuccherato, Daniella C Bartholomeu, Sergio Schenkman, Ricardo T Gazzinelli, Barbara A Burleigh, Najib M El-Sayed, Santuza M R Teixeira
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006767 (2017)
Trypanosoma cruzi, the protozoan that causes Chagas disease, has a complex life cycle involving several morphologically and biochemically distinct stages that establish intricate interactions with various insect and mammalian hosts. It has also a het
Externí odkaz:
https://doaj.org/article/df2f52e5214441558cf3b85fe8452752