Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Rafael B. Frigori"'
Autor:
Ariadne A. Costa, Rafael B. Frigori
Publikováno v:
Frontiers in Research Metrics and Analytics, Vol 9 (2024)
In this study, we analyze the changes over time in the complexity and structure of words used in article titles and the connections between articles in citation networks, focusing on the topic of artificial intelligence (AI) up to 2020. By measuring
Externí odkaz:
https://doaj.org/article/c14c7e1fe7be47208f9fd62e71a66746
Autor:
Fabio Rodrigues, Rafael B. Frigori
Publikováno v:
Journal of Molecular Modeling. 27
Injections of insulin are the main treatment for diabetes, but in the long run this therapy can induce serious drawbacks. This has inspired new drugs able to decrease insulin requirements. For instance, human amylin (hIAPP) is a small hormone cosecre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe964daa6ad1645d2e0fbdd589938b35
https://doi.org/10.1007/s00894-020-04617-9
https://doi.org/10.1007/s00894-020-04617-9
Publikováno v:
The journal of physical chemistry. B. 124(14)
We investigate the prevalence, and so the role in the amyloidogenesis, of biased conformations in large ensembles of monomeric forms for Aβ42 and Aβ40 that can trigger the formation and growth of fibrils described by a dock-lock mechanism. We model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16807bb9f37ddd25d658b1f2310d6c56
https://pubmed.ncbi.nlm.nih.gov/32204595
https://pubmed.ncbi.nlm.nih.gov/32204595
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
We investigate the prevalence, and so the role in the amyloidogenesis, of biased conformations in large ensembles of monomeric forms for Aβ42 and Aβ40 that can trigger the formation and growth of f...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f772e6a37f37093f23754c6c314b2da7
Autor:
Nelson A. Alves, Rafael B. Frigori
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Structural properties of Aβ(16-35) fragment are investigated as a model for the amyloid-β peptide excluding its coil-inducing terminals. Our replica-exchange molecular dynamics simulations using all-atom and explicit aqueous solvation widely reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f910872d2686b7ecb4dfc33f4faec4a
https://doi.org/10.1021/acs.jpcb.7b12528
https://doi.org/10.1021/acs.jpcb.7b12528
Autor:
Rafael B. Frigori
Publikováno v:
Computer Physics Communications. 215:165-172
PHAST is a software package written in standard Fortran, with MPI and CUDA extensions, able to efficiently perform parallel multicanonical Monte Carlo simulations of single or multiple heteropolymeric chains, as coarse-grained models for proteins. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5136cb13933b1dcbdd02723229dcf8ca
https://doi.org/10.1016/j.cpc.2017.01.021
https://doi.org/10.1016/j.cpc.2017.01.021
Autor:
Rafael B. Frigori
Publikováno v:
Physical Chemistry Chemical Physics. 19:25617-25633
Amylin, or human islet amyloid polypeptide (hIAPP), is a 37-residue hormone synergistic to insulin and co-secreted with it by β-cells in the pancreas. The deposition of its cytotoxic amyloid fibrils is strongly related to the progression of Type II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375d8b4f2a9a3decedb7a119aabb6651
https://doi.org/10.1039/c7cp04074a
https://doi.org/10.1039/c7cp04074a
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
The USFDA has approved pramlintide, commercially named Symlin (sIAPP), as adjunctive therapy for type 2 diabetes (T2D). This analogue of the human amylin peptide (hIAPP) has triple proline substitutions typical of the rat isoform (rIAPP). Recently, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e5981305be8fb89c69bd6c09003344
https://doi.org/10.1007/s00894-019-4137-x
https://doi.org/10.1007/s00894-019-4137-x
Autor:
Rafael B. Frigori
Publikováno v:
Computer Physics Communications. 185:2232-2239
High-energy phenomena presenting strong dynamical correlations, long-range interactions and microscopic memory effects are well described by nonextensive versions of the canonical Boltzmann-Gibbs statistical mechanics. After a brief theoretical revie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64912de7c4ec7c093499e3525414b2d
https://doi.org/10.1016/j.cpc.2014.04.016
https://doi.org/10.1016/j.cpc.2014.04.016
Autor:
Rafael B. Frigori
Publikováno v:
Computer Physics Communications. 181:1388-1391
Short-time dynamics technique is used to study the relaxation process for the (2+1)-dimensional critical gluodynamics of the SU(2) lattice gauge theory. A generalized class of heat-bath-inspired updating algorithms was employed during the short-time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19ed2ee1fbf8745d07d8646f39c4a66
https://doi.org/10.1016/j.cpc.2010.04.005
https://doi.org/10.1016/j.cpc.2010.04.005