Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Rafael, Peláez"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/c231c7709baa436eb13d7b888f0d9842
Autor:
Miguel Marín, Javier Sánchez-Montejo, Sergio Ramos, Antonio Muro, Julio López-Abán, Rafael Peláez
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1224 (2024)
Background: Strongyloidiasis, a parasitic infection, presents a significant public health challenge in tropical regions due to the limited repertoire of effective treatments. The screening of chemical libraries against the therapeutically relevant th
Externí odkaz:
https://doaj.org/article/92c88bba84964ba895ca2f9d4605ea58
Autor:
Ronan Nakamura, Nicolás S. Ciranna, Juan C. Fernández, Rafael Peláez, Álvaro Pérez-Sala, Miriam Bobadilla, Juan J. López-Costa, César F. Loidl, Alfredo Martínez, Manuel Rey-Funes
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1983 (2024)
Glaucoma is the second leading cause of blindness worldwide and is, in most cases, a consequence of elevated intraocular pressure (IOP), ultimately resulting in the death of retinal ganglion cells (RGCs). Current treatments are mostly focused on norm
Externí odkaz:
https://doaj.org/article/5effb27710bd42a4a67e34a421fd9951
Autor:
Manuel Rey-Funes, Juan Carlos Fernández, Rafael Peláez, Manuel Soliño, Daniela S. Contartese, Nicolás S. Ciranna, Ronan Nakamura, Aníbal Sarotto, Verónica B. Dorfman, José M. Zapico, Ana Ramos, Beatriz de Pascual-Teresa, Juan José López-Costa, Ignacio M. Larrayoz, Alfredo Martínez, César Fabián Loidl
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Perinatal asphyxia (PA) represents a major problem in perinatology and may cause visual losses, including blindness. We, and others, have shown that hypothermia prevents retinal symptoms associated to PA. In the present work, we evaluat
Externí odkaz:
https://doaj.org/article/818fe5c6e2d848c8ac00bd1381d23422
Autor:
Ana Pariente, Rafael Peláez, Rodrigo Ochoa, Álvaro Pérez-Sala, Ángela Villanueva-Martínez, Miriam Bobadilla, Ignacio M. Larráyoz
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2590 (2023)
Age-related macular degeneration (AMD) is the main cause of blindness in developed countries. AMD is characterized by the formation of drusen, which are lipidic deposits, between retinal pigment epithelium (RPE) and the choroid. One of the main molec
Externí odkaz:
https://doaj.org/article/42dd508a394743d6a879a8abead50393
Autor:
Daniela S. Contartese, Manuel Rey-Funes, Rafael Peláez, Manuel Soliño, Juan C. Fernández, Ronan Nakamura, Nicolás S. Ciranna, Aníbal Sarotto, Verónica B. Dorfman, Juan J. López-Costa, José M. Zapico, Ana Ramos, Beatriz de Pascual-Teresa, Ignacio M. Larrayoz, César F. Loidl, Alfredo Martínez
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Ocular and periocular traumatisms may result in loss of vision. Our previous work showed that therapeutic hypothermia prevents retinal damage caused by traumatic neuropathy. We also generated and characterized small molecules that elici
Externí odkaz:
https://doaj.org/article/c3692b7a46e34c249641c84f1b254f08
Autor:
Myriam González, Pedro José Alcolea, Raquel Álvarez, Manuel Medarde, Vicente Larraga, Rafael Peláez
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 16, Iss , Pp 45-64 (2021)
New drugs against visceral leishmaniasis with mechanisms of action differing from existing treatments and with adequate cost, stability, and properties are urgently needed. No antitubulin drug is currently in the clinic against Leishmania infantum, t
Externí odkaz:
https://doaj.org/article/66c765212478442e893300104bd1f30b
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1698 (2023)
The design of colchicine site ligands on tubulin has proven to be a successful strategy to develop potent antiproliferative drugs against cancer cells. However, the structural requirements of the binding site endow the ligands with low aqueous solubi
Externí odkaz:
https://doaj.org/article/b9b06ce8bf9b4492bb9e9253040d8cbf
Autor:
Laura Gallego-Yerga, Rodrigo Ochoa, Isaías Lans, Carlos Peña-Varas, Melissa Alegría-Arcos, Pilar Cossio, David Ramírez, Rafael Peláez
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4360-4372 (2021)
Tubulin is a well-validated target for herbicides, fungicides, anti-parasitic, and anti-tumor drugs. Many of the non-cancer tubulin drugs bind to its colchicine site but no colchicine-site anticancer drug is available. The colchicine site is composed
Externí odkaz:
https://doaj.org/article/2267eec464c643dea14b7911f56fac0d
Autor:
Myriam González, María Ovejero-Sánchez, Alba Vicente-Blázquez, Manuel Medarde, Rogelio González-Sarmiento, Rafael Peláez
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1029-1047 (2021)
Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the sulphonamide nitrogen have been synthesised. 21 showed sub-micromolar cytotoxicity against HeLa
Externí odkaz:
https://doaj.org/article/ed4db40aad264714b3a1ccaddd495c19