Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Rafael, Kramann"'
Autor:
Xiaohang Shao, Huaming Xu, Hyojin Kim, Sadaf ljaz, Fabian Beier, Vera Jankowski, Michaela Lellig, Lucia Vankann, Jan Niklas Werner, Lu Chen, Susanne Ziegler, Christoph Kuppe, Martin Zenke, Rebekka K. Schneider, Sikander Hayat, Turgay Saritas, Rafael Kramann
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Emerging evidence highlights cellular senescence’s pivotal role in chronic kidney disease (CKD). Proximal tubule epithelial cells (PTECs) and fibroblasts are major players in CKD and serve as cellular sources of senescence. The generation
Externí odkaz:
https://doaj.org/article/3e88d27537d14315a94d3bfb522b83d2
Autor:
Radu Alexa, Jennifer Kranz, Rafael Kramann, Christoph Kuppe, Ritabrata Sanyal, Sikander Hayat, Luis Felipe Casas Murillo, Turkan Hajili, Marco Hoffmann, Matthias Saar
Publikováno v:
European Urology Open Science, Vol 62, Iss , Pp 19-25 (2024)
Background and objective: Hydronephrosis is essential in the diagnosis of renal colic. We automated the detection of hydronephrosis from ultrasound images to standardize the therapy and reduce the misdiagnosis of renal colic. Methods: Anonymously col
Externí odkaz:
https://doaj.org/article/946409f193c847179450336b02818869
Autor:
Mehdi Joodaki, Mina Shaigan, Victor Parra, Roman D Bülow, Christoph Kuppe, David L Hölscher, Mingbo Cheng, James S Nagai, Michaël Goedertier, Nassim Bouteldja, Vladimir Tesar, Jonathan Barratt, Ian SD Roberts, Rosanna Coppo, Rafael Kramann, Peter Boor, Ivan G Costa
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 2, Pp 57-74 (2023)
Abstract Although clinical applications represent the next challenge in single-cell genomics and digital pathology, we still lack computational methods to analyze single-cell or pathomics data to find sample-level trajectories or clusters associated
Externí odkaz:
https://doaj.org/article/ceee0a1c3cb64384992c14d626f0daf2
Autor:
Katharina Charlotte Reimer, Jennifer Nadal, Heike Meiselbach, Matthias Schmid, Ulla T. Schultheiss, Fruzsina Kotsis, Helena Stockmann, Nele Friedrich, Matthias Nauck, Vera Krane, Kai-Uwe Eckardt, Markus P. Schneider, Rafael Kramann, Jürgen Floege, Turgay Saritas, on behalf of the GCKD study investigators
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-8 (2023)
Abstract Mineral and bone disorder (MBD) in chronic kidney disease (CKD) is tightly linked to cardiovascular disease (CVD). In this study, we aimed to compare the prognostic value of nine MBD biomarkers to determine those associated best with adverse
Externí odkaz:
https://doaj.org/article/3d09ae8388934e3592b7202dc7328f7f
Autor:
Verónica Miguel, Rafael Kramann
Publikováno v:
FEBS Open Bio, Vol 13, Iss 7, Pp 1154-1163 (2023)
Fibrosis driven by excessive accumulation of extracellular matrix (ECM) is the hallmark of chronic kidney disease (CKD). Myofibroblasts, which are the cells responsible for ECM production, are activated by cross talk with injured proximal tubule and
Externí odkaz:
https://doaj.org/article/f2616024695f4d6a9a214ac1bd2aa9e3
Autor:
Julian Petersen, Lukas Englmaier, Artem V. Artemov, Irina Poverennaya, Ruba Mahmoud, Thibault Bouderlique, Marketa Tesarova, Ruslan Deviatiiarov, Anett Szilvásy-Szabó, Evgeny E. Akkuratov, David Pajuelo Reguera, Hugo Zeberg, Marketa Kaucka, Maria Eleni Kastriti, Jan Krivanek, Tomasz Radaszkiewicz, Kristína Gömöryová, Sarah Knauth, David Potesil, Zbynek Zdrahal, Ranjani Sri Ganji, Anna Grabowski, Miriam E. Buhl, Tomas Zikmund, Michaela Kavkova, Håkan Axelson, David Lindgren, Rafael Kramann, Christoph Kuppe, Ferenc Erdélyi, Zoltán Máté, Gábor Szabó, Till Koehne, Tibor Harkany, Kaj Fried, Jozef Kaiser, Peter Boor, Csaba Fekete, Jan Rozman, Petr Kasparek, Jan Prochazka, Radislav Sedlacek, Vitezslav Bryja, Oleg Gusev, Igor Adameyko
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually hi
Externí odkaz:
https://doaj.org/article/28aaada8bdf44462afbe36b53f7e9fc6
Autor:
Jessica E. Pritchard, Juliette E. Pearce, Inge A.M. Snoeren, Stijn N.R. Fuchs, Katrin Götz, Fabian Peisker, Silke Wagner, Adam Benabid, Niklas Lutterbach, Vanessa Klöker, James S. Nagai, Monica T. Hannani, Anna K. Galyga, Ellen Sistemich, Bella Banjanin, Niclas Flosdorf, Eric Bindels, Kathrin Olschok, Katharina Biaesch, Nicolas Chatain, Neha Bhagwat, Andrew Dunbar, Rita Sarkis, Olaia Naveiras, Marie-Luise Berres, Steffen Koschmieder, Ross L. Levine, Ivan G. Costa, Hélène F.E. Gleitz, Rafael Kramann, Rebekka K. Schneider
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113608- (2024)
Summary: The role of hematopoietic Hedgehog signaling in myeloproliferative neoplasms (MPNs) remains incompletely understood despite data suggesting that Hedgehog (Hh) pathway inhibitors have therapeutic activity in patients. We aim to systematically
Externí odkaz:
https://doaj.org/article/79a625e34918435f841f28673c9cdf62
Autor:
Verónica Miguel, Carlos Rey-Serra, Jessica Tituaña, Belén Sirera, Elena Alcalde-Estévez, J. Ignacio Herrero, Irene Ranz, Laura Fernández, Carolina Castillo, Lucía Sevilla, James Nagai, Katharina C. Reimer, Jitske Jansen, Rafael Kramann, Ivan G. Costa, Ana Castro, David Sancho, José Miguel Rodríguez González-Moro, Santiago Lamas
Publikováno v:
Redox Biology, Vol 68, Iss , Pp 102957- (2023)
Progressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (COVID-19) pandemic. It is the final outcome of the acute respiratory distress syndrome (ARDS), characterized by an initial exacerbated inflammatory respons
Externí odkaz:
https://doaj.org/article/a3d2c910d76043b19ac7d4579c3da8a2
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Single-cell transcriptomics datasets from the same anatomical sites generated by different research labs are becoming increasingly common. However, fast and computationally inexpensive tools for standardization of cell-type annotation and da
Externí odkaz:
https://doaj.org/article/c7b3a8a0cfcb4cd6bb238b4d11bccbad
Autor:
Sebastian Billig, Marc Hein, Mare Mechelinck, David Schumacher, Anna B. Roehl, Dieter Fuchs, Rafael Kramann, Moritz Uhlig
Publikováno v:
European Radiology Experimental, Vol 7, Iss 1, Pp 1-15 (2023)
Abstract Background Coronary physiology assessment in rodents by ultrasound is an excellent noninvasive and easy to perform technique, including pulsed-wave Doppler (PWD) and myocardial contrast echocardiography (MCE). Both techniques and the corresp
Externí odkaz:
https://doaj.org/article/cb1b69254026436eac037f940b526147