Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Rafał M. Kamiński"'
Autor:
Marcin Jakubiec, Michał Abram, Mirosław Zagaja, Marta Andres-Mach, Aleksandra Szewczyk, Gniewomir Latacz, Bartłomiej Szulczyk, Katarzyna Socała, Dorota Nieoczym, Piotr Wlaź, Cameron S. Metcalf, Karen Wilcox, Rafał M. Kamiński, Krzysztof Kamiński
Publikováno v:
Cells, Vol 11, Iss 12, p 1862 (2022)
In the present study, a focused combinatorial chemistry approach was applied to merge structural fragments of well-known TRPV1 antagonists with a potent anticonvulsant lead compound, KA-104, that was previously discovered by our group. Consequently,
Externí odkaz:
https://doaj.org/article/9d34a801f4aa4feab4747cefcea04a31
Autor:
Michał Abram, Marcin Jakubiec, Anna Rapacz, Szczepan Mogilski, Gniewomir Latacz, Bartłomiej Szulczyk, Małgorzata Szafarz, Katarzyna Socała, Dorota Nieoczym, Elżbieta Wyska, Piotr Wlaź, Rafał M. Kamiński, Krzysztof Kamiński
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 13092 (2021)
We report herein a series of water-soluble analogues of previously described anticonvulsants and their detailed in vivo and in vitro characterization. The majority of these compounds demonstrated broad-spectrum anticonvulsant properties in animal sei
Externí odkaz:
https://doaj.org/article/a1a273109e184c6a9330b827ad6cea4d
Autor:
Michał Abram, Marcin Jakubiec, Anna Rapacz, Szczepan Mogilski, Gniewomir Latacz, Rafał M. Kamiński, Krzysztof Kamiński
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8780 (2020)
Epilepsy belongs to the most common and debilitating neurological disorders with multifactorial pathophysiology and a high level of drug resistance. Therefore, with the aim of searching for new, more effective, and/or safer therapeutics, we discovere
Externí odkaz:
https://doaj.org/article/03681429a411417a8f3d66ee013102ba
Autor:
Michał, Abram, Marcin, Jakubiec, Katelyn, Reeb, Mary Hongying, Cheng, Robin, Gedschold, Anna, Rapacz, Szczepan, Mogilski, Katarzyna, Socała, Dorota, Nieoczym, Małgorzata, Szafarz, Gniewomir, Latacz, Bartłomiej, Szulczyk, Justyna, Kalinowska-Tłuścik, Kinga, Gawel, Camila V, Esguerra, Elżbieta, Wyska, Christa E, Müller, Ivet, Bahar, Andréia C K, Fontana, Piotr, Wlaź, Rafał M, Kamiński, Krzysztof, Kamiński
Publikováno v:
Journal of medicinal chemistry. 65(17)
Autor:
Michał Abram, Kamil Kuś, Szczepan Mogilski, Karolina Matyjaszczyk, Krzysztof Kamiński, Anna Rapacz, Bartłomiej Szulczyk, Maria Walczak, Rafał M. Kamiński, Gniewomir Latacz
Publikováno v:
Epilepsia. 61:2119-2128
Objective The main objective of the present work was to assess the utility of KA-104 as potential therapy for drug-resistant seizures and neuropathic pain, and to characterize its druglike properties in a series of absorption, distribution, metabolis
Autor:
Michał Abram, Marcin Jakubiec, Katelyn Reeb, Mary Hongying Cheng, Robin Gedschold, Anna Rapacz, Szczepan Mogilski, Katarzyna Socała, Dorota Nieoczym, Małgorzata Szafarz, Gniewomir Latacz, Bartłomiej Szulczyk, Justyna Kalinowska-Tłuścik, Kinga Gawel, Camila V. Esguerra, Elżbieta Wyska, Christa E. Müller, Ivet Bahar, Andréia C. K. Fontana, Piotr Wlaź, Rafał M. Kamiński, Krzysztof Kamiński
(R)-7 [(R)-AS-1] showed broad-spectrum antiseizure activity across in vivo mouse seizure models: maximal electroshock (MES), 6 Hz (32/44 mA), acute pentylenetetrazol (PTZ), and PTZ-kindling. A remarkable separation between antiseizure activity and CN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9edda0a63b9b4c266dac589ff4f8da
https://ruj.uj.edu.pl/xmlui/handle/item/299969
https://ruj.uj.edu.pl/xmlui/handle/item/299969
Autor:
Piotr Sklepkiewicz, Barbara A. Dymek, Michal Mlacki, Robert Koralewski, Marzena Mazur, Patrycja Nejman-Gryz, Serdar Korur, Agnieszka Zagozdzon, Aleksandra Rymaszewska, Jan H. von der Thüsen, Anna M. Siwińska, Nazan Cemre Güner, Łukasz Cheda, Magdalena Paplinska-Goryca, Małgorzata Proboszcz, Thierry P.P. van den Bosch, Katarzyna Górska, Jakub Golab, Rafał M. Kamiński, Rafał Krenke, Adam Golebiowski, Karolina Dzwonek, Pawel Dobrzanski
Publikováno v:
European Journal of Pharmacology, 919:174792. Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and eventually fatal lung disease with a complex etiology. Approved drugs, nintedanib and pirfenidone, modify disease progression, but IPF remains incurable and there is an urgent need for new ther
Autor:
Marta Struga, Michał Abram, Rafał M. Kamiński, Dagmara Otto-Ślusarczyk, Justyna Kalinowska-Tłuścik, Gniewomir Latacz, Bartłomiej Szulczyk, Anna Rapacz, Krzysztof Kamiński
Publikováno v:
Bioorganic chemistry. 109
In the current studies we carried out an optimized multistep asymmetric synthesis of R-enantiomers (eutomers) for a previously identified series of racemic hybrid anticonvulsants. The spatial structure of selected enantiomers was solved by the use of
Autor:
Szczepan Mogilski, Annamaria Lubelska, Rafał M. Kamiński, Krzysztof Kamiński, Gniewomir Latacz, Michał Abram, Anna Rapacz
Publikováno v:
ACS chemical neuroscience. 11(13)
We developed a focused set of original hybrid pyrrolidine-2,5-dione derivatives with potent anticonvulsant and antinociceptive properties. These hybrid compounds demonstrated broad-spectrum protective activity in a range of mouse models, such as the
Autor:
Mohammad Mahmud, Charles Wade, Sarah Jawad, Zaeem Hadi, Christian Otoul, Rafal M. Kaminski, Pierandrea Muglia, Irena Kadiu, Eugenii Rabiner, Paul Maguire, David R. Owen, Michael R. Johnson
Publikováno v:
Frontiers in Neuroimaging, Vol 2 (2023)
ObjectiveTranslocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous studies in healt
Externí odkaz:
https://doaj.org/article/8ac866fbfb8544ee9f7ba34f2fbbf4c0