Výsledky vyhledávání - "Rafał Krzysztoń"

Akademický článek

Controllable Acoustic Mixing of Fluids in Microchannels for the Fabrication of Therapeutic Nanoparticles

Autor: Christoph Westerhausen, Lukas G. Schnitzler, Dominik Wendel, Rafał Krzysztoń, Ulrich Lächelt, Ernst Wagner, Joachim O. Rädler, Achim Wixforth

Publikováno v: Micromachines, Vol 7, Iss 9, p 150 (2016)

Fifteen years ago, surface acoustic waves (SAW) were found to be able to drive fluids and numerous applications in microfluidics have been developed since. Here, we review the progress made and report on new approaches in setting-up microfluidic, con

Externí odkaz: https://doaj.org/article/47b22bf9e02643a0900d58ae936c907b

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Gene-circuit therapy on the horizon: synthetic biology tools for engineered therapeutics

Autor: Rafał Krzysztoń, Gábor Balázsi, Julia Petreczky, Yiming Wan

Publikováno v: Acta Biochim Pol

Therapeutic genome modification requires precise control over the introduced therapeutic functions. Current approaches of gene and cell therapy fail to deliver such command and rely on semi-quantitative methods with limited influence on timing, conte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f202c0a68717ac98c9e9a3e81c0c02
https://doi.org/10.18388/abp.2020_5744

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Controlling Nanoparticle Formulation: A Low-Budget Prototype for the Automation of a Microfluidic Platform

Autor: Rafał Krzysztoń, Ernst Wagner, Ulrich Lächelt, Joachim O. Rädler, Dominik M. Loy

Publikováno v: Processes, Vol 9, Iss 129, p 129 (2021)
Processes
Volume 9
Issue 1

Active pharmaceutical ingredients (API) with suboptimal pharmacokinetic properties may require formulation into nanoparticles. In addition to the quality of the excipients, production parameters are crucial for producing nanoparticles which reliably

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5865f49540b4513602a4c63c851a5ed7
https://www.mdpi.com/2227-9717/9/1/129

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Microfluidic self-assembly of folate-targeted monomolecular siRNA-lipid nanoparticles

Autor: Joachim O. Rädler, Ernst Wagner, Dian-Jang Lee, Gerlinde Schwake, B. Salem, Rafał Krzysztoń

Publikováno v: Nanoscale. 9:7442-7453

Non-viral delivery of nucleic acids for therapies based on RNA interference requires a rational design and optimal self-assembly strategies. Nucleic acid particles need to be small, stable and functional in terms of selective cell uptake and controll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506e784aacba11776fbfb385b7b80823
https://doi.org/10.1039/c7nr01593c

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A microfluidic approach for sequential assembly of siRNA polyplexes with defined structure – activity relationship

Autor: Dominik M Loy, Philipp M Klein, Rafał Krzysztoń, Ulrich Lächelt, Joachim O Rädler, Ernst Wagner

Therapeutic nucleic acids provide versatile treatment options for hereditary or acquired diseases. Ionic complexes with basic polymers are frequently used to facilitate nucleic acid’s transport to intracellular target sites. Usually, these polyplex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31272e675abfa35b42d232bd279093cc
https://doi.org/10.7287/peerj.preprints.27669v1

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Correlation of mRNA delivery timing and protein expression in lipid-based transfection

Autor: Daniel Woschée, Anita Reiser, Rafał Krzysztoń, Helmut H. Strey, Neha Mehrotra, Joachim O. Rädler

Publikováno v: Integrative biology : quantitative biosciences from nano to macro. 11(9)

Non-viral gene delivery is constrained by the dwell time that most synthetic nucleic acid nanocarriers spend inside endosomal compartments. In order to overcome this endosomal-release bottleneck, methods are required that measure nanocarrier uptake k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627f80658bc420f95d11ef69d3ab0de2
https://pubmed.ncbi.nlm.nih.gov/31850498

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A microfluidic approach for sequential assembly of siRNA polyplexes with a defined structure-activity relationship

Autor: Rafał Krzysztoń, Philipp M. Klein, Ulrich Lächelt, Ernst Wagner, Joachim O. Rädler, Dominik M. Loy

Publikováno v: PeerJ Materials Science. 1:e1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b829037a8927b3d5f225d0a74ac75ea
https://doi.org/10.7717/peerj-matsci.1

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Structure and Conformational Dynamics of DMPC/Dicationic Surfactant and DMPC/Dicationic Surfactant/DNA Systems

Autor: Rafał Krzysztoń, Zuzanna Pietralik, Maciej Kozak, Wojciech Kida, Weronika Andrzejewska

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 4, Pp 7642-7659 (2013)
International journal of molecular sciences 14, 7642-7659 (2013). doi:10.3390/ijms14047642
International Journal of Molecular Sciences; Volume 14; Issue 4; Pages: 7642-7659
International Journal of Molecular Sciences

Amphiphilic dicationic surfactants, known as gemini surfactants, are currently studied for gene delivery purposes. The gemini surfactant molecule is composed of two hydrophilic “head” groups attached to hydrophobic chains and connected via molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32245840deb290b7e1fd57d1734d19b
http://www.mdpi.com/1422-0067/14/4/7642

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