Výsledky vyhledávání - "Raehannah J. Jamshidi"

14-3-3γ mediates the long-term inhibition of peripheral kappa opioid receptor antinociceptive signaling by norbinaltorphimine

Autor: Michael J. Wedemeyer, Elaine M. Jennings, Hudson R. Smith, Teresa S. Chavera, Raehannah J. Jamshidi, Kelly A. Berg, William P. Clarke

Publikováno v: Neuropharmacology. 220

Long-term inhibition of kappa opioid receptor (KOR) signaling in peripheral pain-sensing neurons is a potential obstacle for development of peripherally-restricted KOR agonists that produce analgesia. Such a long-term inhibitory mechanism is invoked

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc04a03c2e42fe28c0632aef9193591
https://pubmed.ncbi.nlm.nih.gov/36126728

Zobrazit plný text záznamu

Autor: Elaine M. Jennings, Laura C. Sullivan, Raehannah J. Jamshidi, Peter M. LoCoco, Hudson R. Smith, Teresa S. Chavera, Kelly A. Berg, William P. Clarke

Publikováno v: Neuropharmacology. 216

Pain and pain management in the elderly population is a significant social and medical problem. Pain sensation is a complex phenomenon that typically involves activation of peripheral pain-sensing neurons (nociceptors) which send signals to the spina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23882e842a6d3dccf36e1d79d8dffde
https://pubmed.ncbi.nlm.nih.gov/35835212

Zobrazit plný text záznamu

Signaling characteristics and functional regulation of delta opioid-kappa opioid receptor (DOP-KOP) heteromers in peripheral sensory neurons

Autor: Blaine A. Jacobs, Joshua C. Zamora, Miryam M. Pando, Raehannah J. Jamshidi, Elaine M. Jennings, Kelly A. Berg, William P. Clarke, Teresa S. Chavera

Publikováno v: Neuropharmacology

Receptor heteromers often display distinct pharmacological and functional properties compared to the individual receptor constituents. In this study, we compared the properties of the DOP-KOP heteromer agonist, 6ʹ-guanidinonaltrindole (6′-GNTI), w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1c05e02bee96fcd699f6c8e482f9c4
https://pubmed.ncbi.nlm.nih.gov/30776373

Zobrazit plný text záznamu

Abstract P3-12-06: Subpopulations of peripheral sensory neurons are differentially sensitive to the microtubule-targeting agent, paclitaxel

Autor: Peter M LoCoco, Teresa C Chavera, Kelly A. Berg, William P. Clarke, Susan L. Mooberry, Raehannah J. Jamshidi

Publikováno v: Cancer Research. 75:P3-12

Paclitaxel (PTX), a microtubule-targeting anticancer agent, produces a debilitating peripheral neuropathy that is accompanied by neuropathic pain. Patients develop localized pain in their distal extremities, and more frequently complain of increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c22903a663f68587926e2bd265033c0
https://doi.org/10.1158/1538-7445.sabcs14-p3-12-06

Zobrazit plný text záznamu

Constitutive Desensitization of Opioid Receptors in Peripheral Sensory Neurons

Autor: Kelly A. Berg, Teresa S. Chavera, Laura C. Sullivan, Raehannah J. Jamshidi, William P. Clarke

Opioid receptors expressed by peripheral pain-sensing neurons are functionally inactive for antinociceptive signaling under most basal conditions; however, tissue damage or exposure to inflammatory mediators (e.g., bradykinin) converts these receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a992732ef3570941a4cb61aec9e41565
https://europepmc.org/articles/PMC5118646/

Zobrazit plný text záznamu

Functional Selectivity of Kappa Opioid Receptor Agonists in Peripheral Sensory Neurons

Autor: William P. Clarke, Thomas E. Prisinzano, Rachel M Saylor, Laura C. Sullivan, Kelly A. Berg, Raehannah J. Jamshidi, Teresa A. Chavera, Blaine A. Jacobs

Activation of kappa opioid receptors (KORs) expressed by peripheral sensory neurons that respond to noxious stimuli (nociceptors) can reduce neurotransmission of pain stimuli from the periphery to the central nervous system. We have previously shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af71a8ec0688a6f7d94c18b023be45c9
https://europepmc.org/articles/PMC4613959/

Zobrazit plný text záznamu

Autor: Christine Dahlhausen, Raehannah J. Jamshidi, Kelly A. Berg, William P. Clarke, Peter M LoCoco, Teresa A. Chavera, Laura C. Sullivan

Publikováno v: The FASEB Journal. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fc74bee0e62da1146dcba82dacd66a4
https://doi.org/10.1096/fasebj.28.1_supplement.659.2

Zobrazit plný text záznamu

Mechanisms of long‐term regulation of peripheral kappa opioid receptor function by the antagonist, norBNI (659.4)

Autor: Teresa A. Chavera, Laura C. Sullivan, Kelly A. Berg, Raehannah J. Jamshidi, William P. Clarke, Blaine A. McGuire

Publikováno v: The FASEB Journal. 28

KOR is known to regulate cellular signaling cascades including c-Jun N-terminal Kinase (JNK). We have found that norBNI, a prototypical KOR “antagonist”, has “agonist” activity towards JNK, leading...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::263ded0a5d5077994627454fa8fd9e03
https://doi.org/10.1096/fasebj.28.1_supplement.659.4

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání