Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Raed Shalaby"'
Autor:
Raed Shalaby, Jacobus P. Petzer, Anél Petzer, Usman M. Ashraf, Ealla Atari, Fawaz Alasmari, Sivarajan Kumarasamy, Youssef Sari, Ashraf Khalil
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 863-876 (2019)
The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC50 values were found t
Externí odkaz:
https://doaj.org/article/7985cc6fa19d48f0808a64a131e0b1c1
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1638 (2020)
BOK is an evolutionarily conserved BCL-2 family member that resembles the apoptotic effectors BAK and BAX in sequence and structure. Based on these similarities, BOK has traditionally been classified as a BAX-like pro-apoptotic protein. However, the
Externí odkaz:
https://doaj.org/article/5990886cfb3344f3a79408aedf66ddaa
Publikováno v:
Cell death and differentiation.
BOK is a poorly understood member of the BCL-2 family of proteins that has been proposed to function as a pro-apoptotic, BAX-like effector. However, the molecular mechanism and structural properties of BOK pores remain enigmatic. Here, we show that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b3e8f98055d7f5780b75ec1daf04be
https://pubmed.ncbi.nlm.nih.gov/36289446
https://pubmed.ncbi.nlm.nih.gov/36289446
Autor:
John S. H. Danial, Yuri Quintana, Uris Ros, Raed Shalaby, Eleonora G. Margheritis, Sabrina Chumpen Ramirez, Christian Ungermann, Ana J. Garcia-Saez, Katia Cosentino
Publikováno v:
The Journal of Physical Chemistry Letters
Analysis of single-molecule brightness allows subunit counting of high-order oligomeric biomolecular complexes. Although the theory behind the method has been extensively assessed, systematic analysis of the experimental conditions required to accura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd8ec81859c25596f42007552b7d1ee
Autor:
Raed Shalaby, Marwa Mahmoud, Fady Medhat, Ana J Garcia Saez, David Klenerman, John S. H. Danial, Katia Cosentino
Publikováno v:
Bioinformatics. 37:3998-4000
Motivation Imaging single molecules has emerged as a powerful characterization tool in the biological sciences. The detection of these under various noise conditions requires the use of algorithms that are dependent on the end-user inputting several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d6988a07c7c5cbf90b2253a255e89a
https://doi.org/10.1093/bioinformatics/btab352
https://doi.org/10.1093/bioinformatics/btab352
Autor:
Sabrina Chumpen, Katia Cosentino, Raed Shalaby, Eleonora Germana Margheritis, Yuri Quintana, Ana J. García-Sáez, Christian Ungermann, John S. H. Danial, Uris Ros
Analysis of single molecule brightness allows subunit counting of high-order oligomeric biomolecular complexes. Although the theory behind the method has been extensively assessed, systematic analysis of the experimental conditions required to accura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45051241aebd9fc2d6cf27aaaeaece9f
https://doi.org/10.1101/2021.11.22.469513
https://doi.org/10.1101/2021.11.22.469513
Publikováno v:
Biomolecules
Biomolecules, Vol 10, Iss 1638, p 1638 (2020)
Biomolecules, Vol 10, Iss 1638, p 1638 (2020)
BOK is an evolutionarily conserved BCL-2 family member that resembles the apoptotic effectors BAK and BAX in sequence and structure. Based on these similarities, BOK has traditionally been classified as a BAX-like pro-apoptotic protein. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e4dedd937a8d0a808806f014fc6ee4
http://europepmc.org/articles/PMC7762061
http://europepmc.org/articles/PMC7762061
Publikováno v:
Advances in Biomembranes and Lipid Self-Assembly ISBN: 9780128209677
Accurate knowledge of the mechanisms of assembly of protein complexes is essential to understand their structure and control their function. Deep insight into these mechanisms requires information at the single-molecule level to unveil processes whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e561a1181a102451d84427f0adc8fa5c
https://doi.org/10.1016/bs.abl.2020.02.004
https://doi.org/10.1016/bs.abl.2020.02.004
Publikováno v:
ACS Chemical Biology. 12:989-1000
The prosurvival Bcl-2 proteins exhibit a specific pattern of interactions with BH3-only proteins that determines the cellular dependence on apoptotic stress. This specificity is crucial for the development of BH3 mimetics, a class of anticancer molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ad67bf674d084a662d0154d75b3d17
https://doi.org/10.1021/acschembio.6b01084
https://doi.org/10.1021/acschembio.6b01084
Autor:
Mai F. Tolba, Raed Shalaby, Nevine M.Y. Elsayed, Khaled A.M. Abouzid, Dalal A. Abou El Ella, Rabah A. T. Serya
Publikováno v:
MedChemComm. 7:881-899
Three series of novel indazole–pyrimidine based compounds were designed, synthesized and biologically evaluated as VEGFR-2 kinase inhibitors. The most active compound 6i (IC50 = 24.5 nM) was further evaluated against a HUVEC cell line showing an IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5564c785b688362bab66d2c414c3e915
https://doi.org/10.1039/c5md00602c
https://doi.org/10.1039/c5md00602c