Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Radzisheuskaya A"'
Autor:
Tremble, Kathryn C., Stirparo, Giuliano G., Bates, Lawrence E., Maskalenka, Katsiaryna, Stuart, Hannah T., Jones, Kenneth, Andersson-Rolf, Amanda, Radzisheuskaya, Aliaksandra, Koo, Bon-Kyoung, Bertone, Paul, Silva, José C.R.
Publikováno v:
In iScience 19 March 2021 24(3)
Autor:
Iris Müller, Ann Sophie Moroni, Daria Shlyueva, Sudeep Sahadevan, Erwin M. Schoof, Aliaksandra Radzisheuskaya, Jonas W. Højfeldt, Tülin Tatar, Richard P. Koche, Chang Huang, Kristian Helin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Naïve pluripotency is characterized by distinctly open chromatin and repressed endogenous retroviruses. Here the authors show that MPP8 and its association with the core HUSH complex is essential for naïve pluripotent cells; also that repression of
Externí odkaz:
https://doaj.org/article/9597bd4ec7404890a76dbc8df6a59f5c
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100575- (2021)
Summary: Protein degradation technologies represent a powerful functional genomics tool, allowing fast and controllable target protein depletion. Establishing these systems requires a knock-in of the degradation tag into both endogenous target gene a
Externí odkaz:
https://doaj.org/article/a1859a67b9bc414588ca5376f7d5d55f
Autor:
Kathryn C. Tremble, Giuliano G. Stirparo, Lawrence E. Bates, Katsiaryna Maskalenka, Hannah T. Stuart, Kenneth Jones, Amanda Andersson-Rolf, Aliaksandra Radzisheuskaya, Bon-Kyoung Koo, Paul Bertone, José C.R. Silva
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102153- (2021)
Summary: Induced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance, and differentiation of naive pluripotent stem cells (nPSCs). Here, we report that self-renewal of nPSCs requires minimal Sox2 expression (Sox2-
Externí odkaz:
https://doaj.org/article/0ba31fc74d5742b49d4349e5fd86f383
Autor:
Radzisheuskaya, Aliaksandra, Peña‐Rømer, Isabel, Lorenzini, Eugenia, Koche, Richard, Zhan, Yingqian, Shliaha, Pavel V, Cooper, Alexandra J, Fan, Zheng, Shlyueva, Daria, Johansen, Jens V, Hendrickson, Ronald C, Helin, Kristian
Publikováno v:
EMBO Journal; 12/11/2023, Vol. 42 Issue 24, p1-22, 22p
Autor:
William Garland, Itys Comet, Mengjun Wu, Aliaksandra Radzisheuskaya, Leonor Rib, Kristoffer Vitting-Seerup, Marta Lloret-Llinares, Albin Sandelin, Kristian Helin, Torben Heick Jensen
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1800-1811.e6 (2019)
Summary: Pluripotent embryonic stem cells (ESCs) constitute an essential cellular niche sustained by epigenomic and transcriptional regulation. Any role of post-transcriptional processes remains less explored. Here, we identify a link between nuclear
Externí odkaz:
https://doaj.org/article/223db1eaeb4a437a98c993da865c9a39
Autor:
Ross L. Levine, Kris Vaddi, Peggy Scherle, Kristian Helin, Raajit K. Rampal, Richard P. Koche, Benjamin H. Durham, Hong Lin, Min Wang, Jaanvi Mehta, Alexander Grego, Jesper L. Maag, Stephanie Braunstein, Keith B. Cordner, Young C. Park, Anouar Zouak, Aaron D. Viny, Wenbin Xiao, Robert L. Bowman, Bing Li, Aishwarya Krishnan, Abdul Karzai, Aliaksandra Radzisheuskaya, Alessandro Pastore, Neha Bhagwat, Friederike Pastore
We investigated the role of PRMT5 in myeloproliferative neoplasm (MPN) pathogenesis and aimed to elucidate key PRMT5 targets contributing to MPN maintenance. PRMT5 is overexpressed in primary MPN cells, and PRMT5 inhibition potently reduced MPN cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e0ccf89172933899583ca064e5e694
https://doi.org/10.1158/2159-8290.c.6547909.v1
https://doi.org/10.1158/2159-8290.c.6547909.v1
Autor:
Ross L. Levine, Kris Vaddi, Peggy Scherle, Kristian Helin, Raajit K. Rampal, Richard P. Koche, Benjamin H. Durham, Hong Lin, Min Wang, Jaanvi Mehta, Alexander Grego, Jesper L. Maag, Stephanie Braunstein, Keith B. Cordner, Young C. Park, Anouar Zouak, Aaron D. Viny, Wenbin Xiao, Robert L. Bowman, Bing Li, Aishwarya Krishnan, Abdul Karzai, Aliaksandra Radzisheuskaya, Alessandro Pastore, Neha Bhagwat, Friederike Pastore
supplementary tables and material and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989284cc2431486e5a1052fad46da029
https://doi.org/10.1158/2159-8290.22535668
https://doi.org/10.1158/2159-8290.22535668
Autor:
Owen R. Davies, Chia-Yi Lin, Aliaksandra Radzisheuskaya, Xinzhi Zhou, Jessica Taube, Guillaume Blin, Anna Waterhouse, Andrew J.H. Smith, Sally Lowell
Publikováno v:
Cell Reports, Vol 3, Iss 2, Pp 472-484 (2013)
The events that prime pluripotent cells for differentiation are not well understood. Inhibitor of DNA binding/differentiation (Id) proteins, which are inhibitors of basic helix-loop-helix (bHLH) transcription factor activity, contribute to pluripoten
Externí odkaz:
https://doaj.org/article/97cbf2c3a810446b9f806e783c39da4a
Autor:
Hong Lin, Richard Koche, Stephanie Braunstein, Anouar Zouak, Bing Li, Aliaksandra Radzisheuskaya, Peggy Scherle, Min Wang, Aishwarya Krishnan, Kris Vaddi, Young C. Park, Raajit K. Rampal, Abdul Karzai, Neha Bhagwat, Benjamin H. Durham, Aaron D. Viny, Friederike Pastore, Robert L. Bowman, Alexander Grego, Wenbin Xiao, Ross L. Levine, Keith B. Cordner, Jesper L.V. Maag, Jaanvi Mehta, Kristian Helin, Alessandro Pastore
Publikováno v:
Cancer Discovery. 10:1742-1757
We investigated the role of PRMT5 in myeloproliferative neoplasm (MPN) pathogenesis and aimed to elucidate key PRMT5 targets contributing to MPN maintenance. PRMT5 is overexpressed in primary MPN cells, and PRMT5 inhibition potently reduced MPN cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::839f8fd745a9ee2e129e9b9ca7478c6d
https://doi.org/10.1158/2159-8290.cd-20-0026
https://doi.org/10.1158/2159-8290.cd-20-0026