Efficacy and safety of LAU-7b in a Phase 2 trial in adults with cystic fibrosis.

Autor: Konstan MW; Case Western Reserve University School of Medicine and Rainbow Babies and Children's Hospital, OH, USA., Polineni D; Washington University School of Medicine, MO, USA., Chmiel JF; Indiana University School of Medicine and Riley Hospital for Children at IU Health, IN, USA., Bilodeau L; Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, QC, Canada., Middleton PG; CITRICA, Department of Respiratory & Sleep Medicine, Westmead Hospital and Clinical School University of Sydney, NSW, Australia., Matouk E; Research Institute of the McGill University Health Centre, QC, Canada., Houle JM; Laurent Pharmaceuticals Inc., QC, Canada., Pislariu R; Laurent Pharmaceuticals Inc., QC, Canada., Colin P; Laurent Pharmaceuticals Inc., QC, Canada., Kianicka I; Laurent Pharmaceuticals Inc., QC, Canada., Potvin D; Innovaderm Research, QC, Canada., Radzioch D; Research Institute of the McGill University Health Centre, QC, Canada., Kotsimbos T; The Alfred Hospital, Melbourne VIC, Australia., Zuckerman JB; Maine Medical Center, Portland, ME, USA., Nasr SZ; University of Michigan Health System, Ann Arbor, MI, USA., Liou TG; University of Utah, Salt Lake City, UT, USA., Lands LC; Research Institute of the McGill University Health Centre, QC, Canada. Electronic address: larry.lands@mcgill.ca.

Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2024 Jul 09. Date of Electronic Publication: 2024 Jul 09.

CRISPR/Cas9 bioluminescence-based assay for monitoring CFTR trafficking to the plasma membrane.

Autor: Ondra M; https://ror.org/04qxnmv42 Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.; https://ror.org/04qxnmv42 Czech Advanced Technology and Research Institute, Palacky University, Olomouc, Czech Republic., Lenart L; https://ror.org/04qxnmv42 Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic., Centorame A; https://ror.org/01pxwe438 Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada.; RI-MUHC, Montreal, Canada., Dumut DC; https://ror.org/01pxwe438 Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada.; RI-MUHC, Montreal, Canada., He A; https://ror.org/01pxwe438 Physiology, McGill University, Montreal, Canada., Zaidi SSZ; https://ror.org/01pxwe438 Physiology, McGill University, Montreal, Canada., Hanrahan JW; RI-MUHC, Montreal, Canada.; https://ror.org/01pxwe438 Physiology, McGill University, Montreal, Canada., De Sanctis JB; https://ror.org/04qxnmv42 Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic., Radzioch D; https://ror.org/04qxnmv42 Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic danuta.radzioch@mcgill.ca.; https://ror.org/01pxwe438 Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada.; RI-MUHC, Montreal, Canada., Hajduch M; https://ror.org/04qxnmv42 Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic marian.hajduch@upol.cz.; https://ror.org/04qxnmv42 Czech Advanced Technology and Research Institute, Palacky University, Olomouc, Czech Republic.; Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine, University Hospital Olomouc, Olomouc, Czech Republic.

Publikováno v: Life science alliance [Life Sci Alliance] 2023 Nov 02; Vol. 7 (1). Date of Electronic Publication: 2023 Nov 02 (Print Publication: 2024).

315 Developing innovative high-throughput screening assays based on HiBiT-tagged CFTR for identification of CFTR modulators

Autor: Ondra, M., Lenart, L., Centorame, A., Dumut, D., De Sanctis, J., Radzioch, D., Hajduch, M.

Publikováno v: In Journal of Cystic Fibrosis October 2023 22 Supplement 3:S158-S158

The gradient-like separation and reduced running time with Tris-Tricine-HEPES buffer for SDS-PAGE.

Autor: Dumut DC; Department of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada., Garić D; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Centorame A; Department of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada., Radzioch D; Department of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada. Electronic address: danuta.radzioch@mcgill.ca.

Publikováno v: Analytical biochemistry [Anal Biochem] 2022 Sep 15; Vol. 653, pp. 114789. Date of Electronic Publication: 2022 Jun 20.

Characterization of skeletal muscle wasting pathways in diaphragm and limb muscles of cystic fibrosis mice.

Autor: Gusev E; Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada.; Translational Research in Respiratory Diseases Program, McGill University Health Center and Research Institute, Montreal, Quebec, Canada., Liang F; Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada.; Translational Research in Respiratory Diseases Program, McGill University Health Center and Research Institute, Montreal, Quebec, Canada., Bhattarai S; Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada.; Translational Research in Respiratory Diseases Program, McGill University Health Center and Research Institute, Montreal, Quebec, Canada., Broering FE; Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada.; Translational Research in Respiratory Diseases Program, McGill University Health Center and Research Institute, Montreal, Quebec, Canada., Leduc-Gaudet JP; Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada.; Translational Research in Respiratory Diseases Program, McGill University Health Center and Research Institute, Montreal, Quebec, Canada., Hussain SN; Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada.; Translational Research in Respiratory Diseases Program, McGill University Health Center and Research Institute, Montreal, Quebec, Canada., Radzioch D; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Infectious Diseases and Immunity in Global Health Program, McGill University Health Center and Research Institute, Montreal, Quebec, Canada., Petrof BJ; Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada.; Translational Research in Respiratory Diseases Program, McGill University Health Center and Research Institute, Montreal, Quebec, Canada.

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2022 Jun 01; Vol. 322 (6), pp. R551-R561. Date of Electronic Publication: 2022 Apr 12.