Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Radwan Ebna Noor"'
Autor:
Ashleigh B. Bachman, Dimitra Keramisanou, Wanping Xu, Kristin Beebe, Michael A. Moses, M. V. Vasantha Kumar, Geoffrey Gray, Radwan Ebna Noor, Arjan van der Vaart, Len Neckers, Ioannis Gelis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The Hsp90 chaperone cycle is influenced by multiple phosphorylation events but their regulatory functions are poorly understood. Here, the authors show that phosphorylation and unfolding of cochaperone Cdc37 tailors the Hsp90 chaperone cycle by recru
Externí odkaz:
https://doaj.org/article/1ad30120ac2049d29abb8f3ab36b01ec
Publikováno v:
Cancer Research. 83:3844-3844
The aim of this study is to address the challenge of the expression of recombinant atypical protein kinase C (aPKCs) in a bacterial system and understand the binding interactions of novel anti-cancer inhibitors of aPKCs. The Protein kinase Cs (PKCs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c68c8466c6bf1c0d860ea7c94110ff2c
https://doi.org/10.1158/1538-7445.am2023-3844
https://doi.org/10.1158/1538-7445.am2023-3844
Autor:
M V Vasantha Kumar, Radwan Ebna Noor, Ioannis Gelis, Ruslan Sanishvili, Orville A. Pemberton, H. Lee Woodcock, M. Trent Kemp, Yu Chen, Fiona L. Kearns
Publikováno v:
Proc Natl Acad Sci U S A
Gram-negative bacteria expressing class A β-lactamases pose a serious health threat due to their ability to inactivate all β-lactam antibiotics. The acyl–enzyme intermediate is a central milestone in the hydrolysis reaction catalyzed by these enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e35085197c6cad4aad3c2974c2f7b9d
https://doi.org/10.1073/pnas.1922203117
https://doi.org/10.1073/pnas.1922203117
Autor:
Brian S. J. Blagg, Zheng Zhang, Ioannis Gelis, Edvinas Sipavicius, Rachel E. Davis, Radwan Ebna Noor, Vasantha Kumar Mv, Dimitra Keramisanou
Publikováno v:
MedChemComm. 9:1323-1331
Unique to targeting the C-terminal domain of Hsp90 (C-Hsp90) is the ability to uncouple the cytotoxic and cytoprotective outcomes of Hsp90 modulation. After the identification of novobiocin as a C-Hsp90 interacting ligand a diverse gamut of novologue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fcf024f772e66a14f5bb5802368a92
https://doi.org/10.1039/c8md00151k
https://doi.org/10.1039/c8md00151k
Autor:
Nilufar Nahar, MIR Mamun, Md Nashir Uddin Al Mahmud, Radwan Ebna Noor, Muhammad Shamim Al Mamun, Mohammad Shoeb
Publikováno v:
Dhaka University Journal of Science. 65:77-80
Fatty acid compositions, DDT and its metabolites of popular two sea fishes i.e., Pampus argenteus (Pomfret) and Lates calcarifer (Vernacular) were determined. Lipid was extracted by ethylacetate, saponified and converted to methyl ester using BF3-MeO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2747e7999a4f8f61c72be3ba2abf79d8
https://doi.org/10.3329/dujs.v65i1.54510
https://doi.org/10.3329/dujs.v65i1.54510
Autor:
Stephanie Feola, Radwan Ebna Noor, Anita Crispino, Enrico Greco, Ioannis Gelis, Davide Tanasi, Vasantha Kumar
The development of analytical research in recent decades, at the edge between analytical chemistry and archaeology, provides new methods for the study of organic residues that are usually highly sensitive to natural decay. Using Nuclear Magnetic Reso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae18e2ff5b709ec4894ff23c7a4aad8
http://hdl.handle.net/11368/3007372
http://hdl.handle.net/11368/3007372
Autor:
Ashleigh Bachman, Geoffrey M. Gray, Ioannis Gelis, Michael A. Moses, Radwan Ebna Noor, Dimitra Keramisanou, Len Neckers, Kristin Beebe, M V Vasantha Kumar, Arjan van der Vaart, Wanping Xu
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
During the Hsp90-mediated chaperoning of protein kinases, the core components of the machinery, Hsp90 and the cochaperone Cdc37, recycle between different phosphorylation states that regulate progression of the chaperone cycle. We show that Cdc37 pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b3d7bfeac843adb567f032eb2d2f2b
https://pubmed.ncbi.nlm.nih.gov/29343704
https://pubmed.ncbi.nlm.nih.gov/29343704
Publikováno v:
Biophysical Journal. 112:58a-59a
Protein phosphorylation at a single or multiple sites is utilized to regulate protein functional outcomes and overall cellular activities through signaling pathways. At a molecular level, the addition of a phosphoryl group may alter the function of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc612ffeefb67dff08bfb9eea658d66b
https://doi.org/10.1016/j.bpj.2016.11.353
https://doi.org/10.1016/j.bpj.2016.11.353