Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Radwa Sharaf"'
1
Akademický článek
A pan-sarcoma landscape of telomeric content shows that alterations in RAD51B and GID4 are associated with higher telomeric content
Autor: Radwa Sharaf, Dexter X. Jin, John Grady, Christine Napier, Ericka Ebot, Garrett M. Frampton, Lee A. Albacker, David M. Thomas, Meagan Montesion
Publikováno v: npj Genomic Medicine, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Tumor cells need to activate a telomere maintenance mechanism, enabling limitless replication. The bulk of evidence supports that sarcomas predominantly use alternative lengthening of telomeres (ALT) mechanism, commonly associated with alter
Externí odkaz: https://doaj.org/article/392b82449b0c49749d70a0f47dafbda6
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2
Akademický článek
A pan-cancer landscape of telomeric content shows that RAD21 and HGF alterations are associated with longer telomeres
Autor: Radwa Sharaf, Meagan Montesion, Julia F. Hopkins, Jiarong Song, Garrett M. Frampton, Lee A. Albacker
Publikováno v: Genome Medicine, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract Background Cancer cells can proliferate indefinitely through telomere maintenance mechanisms. These mechanisms include telomerase-dependent elongation, mediated by TERT activation, and alternative lengthening of telomeres (ALT), linked to lo
Externí odkaz: https://doaj.org/article/6fb42aa215fa4eadac435596e5d8a55d
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3
Akademický článek
Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
Autor: Leila B. Giron, Clovis S. Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas, Radwa Sharaf, Behzad Etemad, Mohammad Damra, Aaron R. Goldman, Hsin-Yao Tang, Rowena Johnston, Karam Mounzer, Jay R. Kostman, Pablo Tebas, Alan Landay, Luis J. Montaner, Jeffrey M. Jacobson, Jonathan Z. Li, Mohamed Abdel-Mohsen
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Current HIV cure-focused clinical trials rely on analytic treatment interruption (ATI) to evaluate post-treatment control (PTC). Here, combining untargetted metabolomics and glycomics in two HIV clinical cohorts, in vitro assays, and machine learning
Externí odkaz: https://doaj.org/article/8389144aeb1a4d6d950f9fd144f01fe1
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4
Akademický článek
Distinct genomic subclasses of high-grade/progressive meningiomas: NF2-associated, NF2-exclusive, and NF2-agnostic
Autor: Erik A. Williams, Sandro Santagata, Hiroaki Wakimoto, Ganesh M. Shankar, Fred G. Barker, Radwa Sharaf, Abhinav Reddy, Phoebe Spear, Brian M. Alexander, Jeffrey S. Ross, Priscilla K. Brastianos, Daniel P. Cahill, Shakti H. Ramkissoon, Tareq A. Juratli
Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-10 (2020)
Abstract Background Genomic studies of high-grade/progressive meningiomas have reported a heterogeneous mutation spectrum, identifying few recurrently mutated genes. Most studies have been underpowered to detect genomic subclasses of aggressive menin
Externí odkaz: https://doaj.org/article/35b60a8f99044ddca1ea6cdff6638aa2
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5
Akademický článek
Mutations in the TERC template sequence can be incorporated into the telomeres of human tumors.
Autor: Radwa Sharaf, Garrett M Frampton, Lee A Albacker
Publikováno v: PLoS ONE, Vol 17, Iss 8, p e0272707 (2022)
Telomerase-mediated lengthening is a mechanism by which some cancer cells avoid senescence-mediated cell cycle arrest due to shortened telomeres. By reverse transcribing an RNA template, encoded by TERC, the enzyme telomerase synthesizes the elongati
Externí odkaz: https://doaj.org/article/d67cb5553f29495b8943cf4449d83856
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6
Autologous neutralizing antibodies increase with early antiretroviral therapy and shape HIV rebound after treatment interruption
Autor: Elmira Esmaeilzadeh, Behzad Etemad, Christy L. Lavine, Lauren Garneau, Yijia Li, James Regan, Colline Wong, Radwa Sharaf, Elizabeth Connick, Paul Volberding, Manish Sagar, Michael S. Seaman, Jonathan Z. Li
Publikováno v: Science Translational Medicine. 15
Early initiation of antiretroviral therapy (ART) alters viral rebound kinetics after analytic treatment interruption (ATI) and may play a role in promoting HIV-1 remission. Autologous neutralizing antibodies (aNAbs) represent a key adaptive immune re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f9c47f9d78b07ae424efbe6e3d2b8e6
https://doi.org/10.1126/scitranslmed.abq4490
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Plný text Recenzováno Digitální knihovna AV ČR
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