Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Radwa H. Abou-Saleh"'
Autor:
Nicola Ingram, Radwa H. Abou-Saleh, Amanda D. Race, Paul M. Loadman, Richard J. Bushby, Stephen D. Evans, P. Louise Coletta
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 434 (2024)
Therapeutic microbubbles (thMBs) contain drug-filled liposomes linked to microbubbles and targeted to vascular proteins. Upon the application of a destructive ultrasound trigger, drug uptake to tumour is improved. However, the structure of thMBs curr
Externí odkaz:
https://doaj.org/article/abff952cecfb4e338f01079ea86da640
Autor:
Nicola Ingram, Laura E. McVeigh, Radwa H. Abou-Saleh, Damien V. B. Batchelor, Paul M. Loadman, James R. McLaughlan, Alexander F. Markham, Stephen D. Evans, P. Louise Coletta
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 622 (2022)
Advanced drug delivery systems, such as ultrasound-mediated drug delivery, show great promise for increasing the therapeutic index. Improvements in delivery by altering the ultrasound parameters have been studied heavily in vitro but relatively littl
Externí odkaz:
https://doaj.org/article/102e52c5286745469f1868078ad550f9
Autor:
Radwa H. Abou-Saleh, Mercedes C. Hernandez-Gomez, Sam Amsbury, Candelas Paniagua, Matthieu Bourdon, Shunsuke Miyashima, Ykä Helariutta, Martin Fuller, Tatiana Budtova, Simon D. Connell, Michael E. Ries, Yoselin Benitez-Alfonso
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Despite their importance in plant development and defence the properties of (1,3)-β-glucan remain largely unknown. Here, the authors find that addition of (1,3)-β-glucans increases the flexibility of cellulose and its resilience to high strain, an
Externí odkaz:
https://doaj.org/article/59e67a1bb0b349f58338a37f36a87bdb
Autor:
Nicola Ingram, P. Louise Coletta, Radwa H. Abou-Saleh, Damien V. B. Batchelor, Benjamin R. G. Johnson, Sally A. Peyman, Antonia Charalambous, Richard J. Bushby, Alexander F. Markham, Aileen Delaney, Stephen D. Evans
Publikováno v:
ACS Applied Bio Materials. 3:7840-7848
Microbubbles (MBs) are widely used as contrast enhancement agents for ultrasound imaging and have the potential to enhance therapeutic delivery to diseases such as cancer. Yet, they are only stable in solution for a few hours to days after production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06467c5e57baac60514978604d89dbc
https://doi.org/10.1021/acsabm.0c00982
https://doi.org/10.1021/acsabm.0c00982
Autor:
Richard J. Bushby, Stephen D. Evans, Radwa H. Abou-Saleh, Jonathan Sandoe, Daniel A. Paterson, J. Cliff Jones, Sally A. Peyman, Peng Bao, Helen F. Gleeson
Publikováno v:
Langmuir. 36:6436-6446
In liquid crystal (LC) droplets, small changes in surface anchoring energy can produce large changes in the director field which result in readily detectable optical effects. This makes them attractive for use as biosensors. Coating LC droplets with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a902b918f0bc2f656072bffc359373
https://doi.org/10.1021/acs.langmuir.0c00651
https://doi.org/10.1021/acs.langmuir.0c00651
Autor:
Radwa H. Abou-Saleh, Sally A. Peyman, Damien V. B. Batchelor, Benjamin R. G. Johnson, Stephen D. Evans, Fern J. Armistead
Publikováno v:
The Review of scientific instruments. 92(7)
Microbubbles (MBs) have a multitude of applications including as contrast agents in ultrasound imaging and as therapeutic drug delivery vehicles, with further scope for combining their diagnostic and therapeutic properties (known as theranostics). MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da5affd7b96d3315b00075b6464a405
https://pubmed.ncbi.nlm.nih.gov/34340422
https://pubmed.ncbi.nlm.nih.gov/34340422
Autor:
James R. McLaughlan, Radwa H. Abou-Saleh, Stephen D. Evans, Richard J. Bushby, Neil H. Thomson, Steven Freear, Benjamin R. G. Johnson
Publikováno v:
Langmuir. 35:10097-10105
The production and stability of microbubbles (MBs) is enhanced by increasing the viscosity of both the formation and storage solution, respectively. Glycerol is a good candidate for biomedical applications of MBs, since it is biocompatible, although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bdbd381de91a756afc6bccb3bec18a
https://doi.org/10.1021/acs.langmuir.8b04130
https://doi.org/10.1021/acs.langmuir.8b04130
Autor:
Sally A. Peyman, Malcolm Haddrick, William Townley, Michael Fairclough, Elizabeth M. A. Valleley, Nicola Ingram, Antonia Wierzbicki, Richard J. Bushby, Radwa H. Abou-Saleh, Stephen D. Evans, Pamela F. Jones, Gemma Marston, Darren Treanor, Milene Volpato, Antonia Charalambous, Juliana Maynard, Neil H. Thomson, Laura E. McVeigh, J. Anthony Evans, Jorge L Jimenez-Macias, A Wright, P. Louise Coletta, Peter B Simpson, Benjamin R. G. Johnson, Steven Freear, Alexander F. Markham, James R. McLaughlan, Paul M. Loadman
Publikováno v:
Fairclough, M 2020, ' Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumour drug accumulation and limiting bioavailability and toxicity in normal tissues ', Theranostics, vol. 10, no. 4 . https://doi.org/10.7150/thno.49670
Ingram, N, McVeigh, L E, Abou-Saleh, R H, Maynard, J, Peyman, S A, McLaughlan, J R, Fairclough, M, Marston, G, Valleley, E M A, Jimenez-Macias, J L, Charalambous, A, Townley, W, Haddrick, M, Wierzbicki, A, Wright, A, Volpato, M, Simpson, P B, Treanor, D E, Thomson, N H, Loadman, P M, Bushby, R J, Johnson, B R G, Jones, P F, Evans, J A, Freear, S, Markham, A F, Evans, S D & Coletta, P L 2020, ' Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues ', Theranostics, vol. 10, no. 24, pp. 10973-10992 . https://doi.org/10.7150/thno.49670
Theranostics
Ingram, N, McVeigh, L E, Abou-Saleh, R H, Maynard, J, Peyman, S A, McLaughlan, J R, Fairclough, M, Marston, G, Valleley, E M A, Jimenez-Macias, J L, Charalambous, A, Townley, W, Haddrick, M, Wierzbicki, A, Wright, A, Volpato, M, Simpson, P B, Treanor, D E, Thomson, N H, Loadman, P M, Bushby, R J, Johnson, B R G, Jones, P F, Evans, J A, Freear, S, Markham, A F, Evans, S D & Coletta, P L 2020, ' Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues ', Theranostics, vol. 10, no. 24, pp. 10973-10992 . https://doi.org/10.7150/thno.49670
Theranostics
Most cancer patients receive chemotherapy at some stage of their treatment which makes improving the efficacy of cytotoxic drugs an ongoing and important goal. Despite large numbers of potent anti-cancer agents being developed, a major obstacle to cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8743562efc9f20857e1d1305e425ca8f
https://www.research.manchester.ac.uk/portal/en/publications/ultrasoundtriggered-therapeutic-microbubbles-enhance-the-efficacy-of-cytotoxic-drugs-by-increasing-circulation-and-tumour-drug-accumulation-and-limiting-bioavailability-and-toxicity-in-normal-tissues(d99d292e-9ff7-4039-a343-5bfeafca0d06).html
https://www.research.manchester.ac.uk/portal/en/publications/ultrasoundtriggered-therapeutic-microbubbles-enhance-the-efficacy-of-cytotoxic-drugs-by-increasing-circulation-and-tumour-drug-accumulation-and-limiting-bioavailability-and-toxicity-in-normal-tissues(d99d292e-9ff7-4039-a343-5bfeafca0d06).html
Autor:
Sally A. Peyman, James R. McLaughlan, Damien V. B. Batchelor, Radwa H. Abou-Saleh, Stephen D. Evans, P. Louise Coletta
Publikováno v:
ACS Applied Materials & Interfaces
Because of their size (1-10 μm), microbubble-based drug delivery agents suffer from confinement to the vasculature, limiting tumor penetration and potentially reducing the drug efficacy. Nanobubbles (NBs) have emerged as promising candidates for ult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22252799f7be72522e3bfd4d0b955e2
https://doi.org/10.1021/acsami.0c07022
https://doi.org/10.1021/acsami.0c07022
Autor:
Radwa H. Abou-Saleh, Sally A. Peyman, Stephen D. Evans, Sevan Harput, James R. McLaughlan, Steven Freear
Publikováno v:
Ultrasound in Medicine & Biology. 43(1):346-356
Therapeutic microbubbles could make an important contribution to the diagnosis and treatment of cancer. Acoustic characterisation was performed on microfluidic generated microbubble populations that either were bare or had liposomes attached. Through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d72fd9bb665a0f907f8270fdd4b2714