Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Radu O. Minea"'
Autor:
Catalina Silva-Hirschberg, Hannah Hartman, Samantha Stack, Steve Swenson, Radu O. Minea, Michael A. Davitz, Thomas C. Chen, Axel H. Schönthal
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 11 (2019)
Background: Mycosis fungoides (MF) and Sézary syndrome (SS) are subtypes of primary cutaneous lymphomas and represent complex diseases regarding their physiopathology and management. Depending on the stage of the disease, different treatment regimen
Externí odkaz:
https://doaj.org/article/6f8923ff18ae4271b600c5369da99084
Autor:
Steve Swenson, Radu O. Minea, Cao Duc Tuan, Thu-Zan Thein, Thomas C. Chen, Francis S. Markland
Publikováno v:
Molecules, Vol 23, Iss 11, p 2918 (2018)
We developed a bacterial expression system to produce a recombinant disintegrin, vicrostatin (VCN), whose structure is based on a natural disintegrin isolated from southern copperhead snake venom. Our goal is to develop VCN for potential clinical tra
Externí odkaz:
https://doaj.org/article/0500811d701f4fb1977ce3622aa02ba3
Autor:
Weijun Wang, Haiping He, Shan Zeng, Hee-Yeon Cho, Radu O. Minea, Steven D. Swenson, Long Zheng, Alan L. Epstein, Apostolos Stathopoulos, Ligang Chen, Axel H. Schönthal, Thomas C. Chen
Publikováno v:
Journal of Neurosurgery. :1-9
OBJECTIVE Immune checkpoint-inhibitory therapeutic antibodies have shown striking activity against several types of cancers but are less effective against brain-localized malignancies, in part due to the protective effect of the blood-brain barrier (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ad7d55c548a65370db71df8a177a49c
https://doi.org/10.3171/2022.12.jns221285
https://doi.org/10.3171/2022.12.jns221285
Autor:
Radu O Minea, Tuan Cao Duc, Stephen D Swenson, Hee-Yeon Cho, Mickey Huang, Hannah Hartman, Florence M Hofman, Axel H Schönthal, Thomas C Chen
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238238 (2020)
The prognosis for patients with glioblastoma (GB) remains grim. Concurrent temozolomide (TMZ) radiation-the cornerstone of glioma control-extends the overall median survival of GB patients by only a few months over radiotherapy alone. While these sur
Externí odkaz:
https://doaj.org/article/06b1342876a949aa97d7626567027847
Publikováno v:
Cancers; Volume 14; Issue 24; Pages: 6065
Many patients with acute myeloid leukemia (AML) are still dying from this disease. In the past, the alkylating agent temozolomide (TMZ) has been investigated for AML and found to be partially effective; however, the presence of O6-methylguanine DNA m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c734bef4da2db03bb3afe012672eb88d
Autor:
Nazleen Mohseni, Hee-Yeon Cho, Yong-Mi Kim, Thomas C. Chen, Axel H. Schönthal, Hye Na Kim, Radu O. Minea, Steve Swenson
Publikováno v:
Cancers
Cancers, Vol 13, Iss 3385, p 3385 (2021)
Volume 13
Issue 14
Cancers, Vol 13, Iss 3385, p 3385 (2021)
Volume 13
Issue 14
Simple Summary Many patients are still dying from acute myeloid leukemia (AML). Initial treatment of this blood-borne cancer consists of chemotherapy, usually with the agent cytarabine (AraC). However, the cancer cells can become drug resistant and u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d783fe30a1452a831e6c1f31c9f22d2
http://europepmc.org/articles/PMC8305595
http://europepmc.org/articles/PMC8305595
Autor:
Radu O Minea, Corey M Helchowski, Samuel J Zidovetzki, Fritz K Costa, Stephen D Swenson, Francis S Markland
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10929 (2010)
Similar to other integrin-targeting strategies, disintegrins have previously shown good efficacy in animal cancer models with favorable pharmacological attributes and translational potential. Nonetheless, these polypeptides are notoriously difficult
Externí odkaz:
https://doaj.org/article/14648aebbdc544c5988dfa92d26ec79e
Autor:
Axel H. Schönthal, Hannah Hartman, Steve Swenson, Thomas C. Chen, Michael A Davitz, Radu O. Minea, Catalina Silva-Hirschberg, Samantha Stack
Publikováno v:
Therapeutic Advances in Medical Oncology
Therapeutic Advances in Medical Oncology, Vol 11 (2019)
Therapeutic Advances in Medical Oncology, Vol 11 (2019)
Background: Mycosis fungoides (MF) and Sézary syndrome (SS) are subtypes of primary cutaneous lymphomas and represent complex diseases regarding their physiopathology and management. Depending on the stage of the disease, different treatment regimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad097493650e1cc49c07c683f84953f
https://pubmed.ncbi.nlm.nih.gov/31839810
https://pubmed.ncbi.nlm.nih.gov/31839810
Publikováno v:
Cancer Research. 81:PO030-PO030
Disintegrins are disulfide-rich peptides, many containing an Arg-Gly-Asp (RGD) motif. They hold significant translational potential as anti-cancer agents based on their high-affinity/high-specificity interaction with tumor integrins and desirable pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e402d4d619d5c3b53d6c17d0128f610c
https://doi.org/10.1158/1538-7445.tme21-po030
https://doi.org/10.1158/1538-7445.tme21-po030
Autor:
Axel H. Schönthal, Hannah Hartman, Thomas C. Chen, Radu O. Minea, Tuan Cao Duc, Florence M. Hofman, Mickey Huang, Stephen Swenson, Hee-Yeon Cho
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238238 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238238 (2020)
The prognosis for patients with glioblastoma (GB) remains grim. Concurrent temozolomide (TMZ) radiation-the cornerstone of glioma control-extends the overall median survival of GB patients by only a few months over radiotherapy alone. While these sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc3059dd05d85d75cc16321392dbc8a
https://doi.org/10.1371/journal.pone.0238238
https://doi.org/10.1371/journal.pone.0238238