Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes

Autor: Acosta-Herrera, Marialbert, Kerick, Martin, Lopéz-Isac, Elena, Assassi, Shervin, Beretta, Lorenzo, Simeón-Aznar, Carmen Pilar, Ortego-Centeno, Norberto, International SSc Group, Proudman, Susanna M, Australian Scleroderma Interest Group (ASIG), Hunzelmann, Nicolas, Moroncini, Gianluca, de Vries-Bouwstra, Jeska K, Orozco, Gisela, Barton, Anne, Herrick, Ariane L, Terao, Chikashi, Allanore, Yannick, Brown, Matthew A, Radstake, Timothy Rdj, Fonseca, Carmen, Denton, Christopher P, Mayes, Maureen D, Martin, Javier

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, 80(8), 1040-1047. BMJ PUBLISHING GROUP
Ann Rheum Dis . 2021 Apr 1;80(8):1040-1047
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Scientia

Objective The greatest genetic effect reported for systemic sclerosis (SSc) lies in the major histocompatibility complex (MHC) locus. Leveraging the largest SSc genome-wide association study, we aimed to fine-map this region to identify novel human l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1aa3b23b3a7ed7d024352e8903f1b81
https://hdl.handle.net/10668/17969

Decreased expression of TSLP in labial salivary glands of patients with primary Sjögren’s syndrome is associated with local- and systemic disease parameters

Autor: Hillen Maarten R, Bikker Angela, Kruize Aike A, Wenting-van Wijk Marion, Lafeber Floris PJG, Hack C, Radstake Timothy RDJ, van Roon Joel AG

Publikováno v: Journal of Translational Medicine, Vol 10, Iss Suppl 3, p P36 (2012)

Externí odkaz: https://doaj.org/article/bcca35cddfcf4367b03c3ee446e9bedf

Integration of immunome with disease gene network reveals pleiotropy and novel drug repurposing targets

Autor: Devaprasad, Abhinandan, Radstake, Timothy RDJ, Pandit, Aridaman

Immune system is crucial for the development and progression of immune-mediated and non-immune mediated complex diseases. Studies have shown that multiple complex diseases are associated with several immunologically relevant genes. Despite such growi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::c5232d3d9febf8d097cd3f2ff7534332

Genetics of scleroderma: implications for personalized medicine?

Autor: Assassi Shervin, Radstake Timothy RDJ, Mayes Maureen D, Martin Javier

Publikováno v: BMC Medicine, Vol 11, Iss 1, p 9 (2013)

Abstract Significant advances have been made in understanding the genetic basis of systemic sclerosis (scleroderma) in recent years. Can these discoveries lead to individualized monitoring and treatment? Besides robustly replicated genetic susceptibi

Externí odkaz: https://doaj.org/article/b107edf154e3400c9835f8cafc75454f

Cross-disease Meta-analysis of Genome-wide Association Studies for Systemic Sclerosis and Rheumatoid Arthritis Reveals IRF4 as a New Common Susceptibility Locus

Autor: López-Isac, Elena, Martín, Jose-Ezequiel, Assassi, Shervin, Simeón, Carmen P, Carreira, Patricia, Ortego-Centeno, Norberto, Freire, Mayka, Beltrán, Emma, Narváez, Javier, Alegre-Sancho, Juan J, Fernández-Gutiérrez, Benjamín, Balsa, Alejandro, Ortiz, Ana M, González-Gay, Miguel A, Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Witte, Torsten, Hunzelmann, Nicolas, Distler, Jörg HW, Riekemasten, Gabriella, van der Helm-van Mil, Annete H, de Vries-Bouwstra, Jeska, Magro-Checa, Cesar, Voskuyl, Alexandre E, Vonk, Madelon C, Molberg, Øyvind, Merriman, Tony, Hesselstrand, Roger, Nordin, Annika, Padyukov, Leonid, Herrick, Ariane, Eyre, Steve, Koeleman, Bobby PC, Denton, Christopher P, Fonseca, Carmen, Radstake, Timothy RDJ, Worthington, Jane, Mayes, Maureen D, Martín, Javier

Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc-RA genetic loci have been identified independently. The aim of the current study wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df8f94cb1a1ec07dffdf86f9ff2a254b
https://europepmc.org/articles/PMC5530728/