Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Radovan Fiser"'
Autor:
Anna Lepesheva, Adriana Osickova, Jana Holubova, David Jurnecka, Sarka Knoblochova, Carlos Espinosa-Vinals, Ladislav Bumba, Karolina Skopova, Radovan Fiser, Radim Osicka, Peter Sebo, Jiri Masin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Pore-forming repeats in toxins (RTX) are key virulence factors of many Gram-negative pathogens. We have recently shown that the aromatic side chain of the conserved tyrosine residue 940 within the acylated segment of the RTX adenylate cyclas
Externí odkaz:
https://doaj.org/article/6f873568b2e4490a9da5948d8fb80b36
Autor:
Radovan Fiser, Jiri Masin, Ladislav Bumba, Eva Pospisilova, Catherine Fayolle, Marek Basler, Lenka Sadilkova, Irena Adkins, Jana Kamanova, Jan Cerny, Ivo Konopasek, Radim Osicka, Claude Leclerc, Peter Sebo
Publikováno v:
PLoS Pathogens, Vol 8, Iss 4, p e1002580 (2012)
Bordetella adenylate cyclase toxin-hemolysin (CyaA) penetrates the cytoplasmic membrane of phagocytes and employs two distinct conformers to exert its multiple activities. One conformer forms cation-selective pores that permeabilize phagocyte membran
Externí odkaz:
https://doaj.org/article/61bbaf2f46a14d88aeb943ef33d85b35
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000901 (2010)
Bordetella adenylate cyclase toxin (CyaA) binds the alpha(M)beta(2) integrin (CD11b/CD18, Mac-1, or CR3) of myeloid phagocytes and delivers into their cytosol an adenylate cyclase (AC) enzyme that converts ATP into the key signaling molecule cAMP. We
Externí odkaz:
https://doaj.org/article/61e2561695af418790e7c6f6a82db51e
Autor:
Klára Látrová, Noemi Havlová, Renata Večeřová, Dominik Pinkas, Kateřina Bogdanová, Milan Kolář, Radovan Fišer, Ivo Konopásek, Duy Dinh Do Pham, Dominik Rejman, Gabriela Mikušová
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Lipophosphonoxins (LPPOs) are small modular synthetic antibacterial compounds that target the cytoplasmic membrane. First-generation LPPOs (LPPO I) exhibit an antimicrobial activity against Gram-positive bacteria; however they do not exhibit
Externí odkaz:
https://doaj.org/article/2c8af9111366446e9e22f3b263b30b4d
Autor:
Radovan, Fiser, Jirí, Masín, Marek, Basler, Jan, Krusek, Veronika, Spuláková, Ivo, Konopásek, Peter, Sebo
Publikováno v:
The Journal of biological chemistry. 282(5)
The Bordetella adenylate cyclase toxin-hemolysin (CyaA) targets phagocytes expressing the alpha(M)beta2 integrin (CD11b/CD18), permeabilizes their membranes by forming small cation-selective pores, and delivers into cells a calmodulin-activated adeny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8d33cba61555a56d260a7effed32916
https://pubmed.ncbi.nlm.nih.gov/17148436
https://pubmed.ncbi.nlm.nih.gov/17148436
Autor:
Natalya Panova, Eva Zborníková, Ondřej Šimák, Radek Pohl, Milan Kolář, Kateřina Bogdanová, Renata Večeřová, Gabriela Seydlová, Radovan Fišer, Romana Hadravová, Hana Šanderová, Dragana Vítovská, Michaela Šiková, Tomáš Látal, Petra Lovecká, Ivan Barvík, Libor Krásný, Dominik Rejman
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145918 (2015)
The advantages offered by established antibiotics in the treatment of infectious diseases are endangered due to the increase in the number of antibiotic-resistant bacterial strains. This leads to a need for new antibacterial compounds. Recently, we d
Externí odkaz:
https://doaj.org/article/645b79dd6ac04f01b3677db66966ded9