Výsledky vyhledávání - "Radouane Koudih"

Designing Silylatedl-Amino Acids using a Wittig Strategy: Synthesis of Peptide Derivatives and18F-Labelling

Autor: Raluca Malacea-Kabbara, Radouane Koudih, Delphine Vimont, Hassib Audi, Pawel Jewula, Baptiste Rugeri, Sylvain Jugé, Philippe Fernandez, Jürgen Schulz

Publikováno v: European Journal of Organic Chemistry. 2017:5399-5409

An efficient semisynthesis of silylated l-amino acids by reaction of silylated benzaldehydes with a phosphonium l-amino acid used as a Wittig reagent is described. The efficiency of the silylated l-amino acids in peptide synthesis was investigated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e7d8b177c3f501258b572686e63d30e
https://doi.org/10.1002/ejoc.201701170

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Synthesis and in vitro characterization of trans- and cis-[(18)F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-D-aspartate receptor

Autor: Gwénaëlle Gilbert, Ahmed Abbas, Louisa Barré, Martine Dhilly, Radouane Koudih, Danièle Debruyne, Franck Sobrio

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2012, 53, pp.408-415. ⟨10.1016/j.ejmech.2012.04.011⟩
European Journal of Medicinal Chemistry, 2012, 53, pp.408-415. ⟨10.1016/j.ejmech.2012.04.011⟩

Diastereoisomeric compounds [18F]cis- and [18F]trans-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoro-piperidine-1-carboxylates were successfully synthesized as new subtype-selective PET radiotracers for imaging the NR2B subunit containing NMD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6c996f27516b9abe6c0520237e42b1
https://pubmed.ncbi.nlm.nih.gov/22554495

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Radiolabelling of 1,4-disubstituted 3-[18F]fluoropiperidines and its application to new radiotracers for NR2B NMDA receptor visualization

Autor: Gwénaëlle Gilbert, Ahmed Abbas, Louisa Barré, Martine Dhilly, Radouane Koudih, Franck Sobrio, Danièle Debruyne

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10 (42), ⟨10.1039/c2ob26378e⟩
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2012, 10 (42), ⟨10.1039/c2ob26378e⟩

In order to develop a novel and useful building block for the development of radiotracers for positron emission tomography (PET), we studied the radiolabelling of 1,4-disubstituted 3-[(18)F]fluoropiperidines. Indeed, 3-fluoropiperidine became a usefu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a5baeb2703b858aba91541d563afa9
https://hal.archives-ouvertes.fr/hal-01853954

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