Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Radoslaw Kitel"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Initiation of the bradykinin generation cascade is responsible for the occurrence of attacks in some types of angioedema without wheals. Hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) is one such clinical entity. In this paper, we
Externí odkaz:
https://doaj.org/article/fa2e6dc15b544ec68200b87b566e0cfd
Autor:
Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodríguez, Katarzyna Magiera-Mularz, Alexander Dömling, Tad A. Holak, Ewa Surmiak
Publikováno v:
Molecules, Vol 29, Iss 12, p 2926 (2024)
In the published publication [...]
Externí odkaz:
https://doaj.org/article/07c96bba301f4128b33fe3b92feb0447
Autor:
Maria Hoyer, Alvaro H. Crevenna, Radoslaw Kitel, Kherim Willems, Miroslawa Czub, Grzegorz Dubin, Pol Van Dorpe, Tad A. Holak, Don C. Lamb
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Protein assembly plays an important role throughout all phyla of life, both physiologically and pathologically. In particular, aggregation and polymerization of proteins are key-strategies that regulate cellular function. In recent years, me
Externí odkaz:
https://doaj.org/article/374bc760346c4888950b3aa4914343b0
Autor:
Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodríguez, Katarzyna Magiera-Mularz, Alexander Dömling, Tad A. Holak, Ewa Surmiak
Publikováno v:
Molecules, Vol 27, Iss 23, p 8282 (2022)
By binding to the spliceosomal protein Snu66, the human ubiquitin-like protein Hub1 is a modulator of the spliceosome performance and facilitates alternative splicing. Small molecules that bind to Hub1 would be of interest to study the protein-protei
Externí odkaz:
https://doaj.org/article/4d220aacd0f442a4af06fca7242ed41d
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1079 (2021)
The pharmacological effects of carbon to silicon bioisosteric replacements have been widely explored in drug design and medicinal chemistry. Here, we present a systematic investigation of the impact of different silyl groups on the anticancer activit
Externí odkaz:
https://doaj.org/article/2e9510c367bf467eb0f61b2b60ff04f6
Autor:
Florian Nietzold, Stefan Rubner, Beata Labuzek, Przemysław Golik, Ewa Surmiak, Xabier del Corte, Radoslaw Kitel, Christoph Protzel, Regina Reppich‐Sacher, Jan Stichel, Katarzyna Magiera‐Mularz, Tad A. Holak, Thorsten Berg
Publikováno v:
ChemBioChem. 24
Nutlin-3a is a reversible inhibitor of the p53/MDM2 interaction. We have synthesized the derivative Nutlin-3a-aa bearing an additional exocyclic methylene group in the piperazinone moiety. Nutlin-3a-aa is more active than Nutlin-3a against purified w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb06c4062024a2ef43bf959329aea0f
https://doi.org/10.1002/cbic.202300006
https://doi.org/10.1002/cbic.202300006
Autor:
Lukasz Skalniak, Radoslaw Kitel, Jacek Plewka, Tad A. Holak, Bogdan Musielak, Damian Muszak, Ewa Surmiak, Justyna Kocik-Krol, Katarzyna Magiera-Mularz
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11797, p 11797 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Targeting the programmed cell death protein 1/programmed cell death 1 ligand 1 (PD-1/PD-L1) interaction has become an established strategy for cancer immunotherapy. Although hundreds of small-molecule, peptide, and peptidomimetic inhibitors have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f846fc8bfbfa8eca4fdf24197328b1f
https://pubmed.ncbi.nlm.nih.gov/34769226
https://pubmed.ncbi.nlm.nih.gov/34769226
Autor:
Maciej Siedlar, Jacek Plewka, Tad A. Holak, Ewa Surmiak, Alexander Dömling, Radoslaw Kitel, Małgorzata Stec, Bogdan Musielak, Łukasz Skalniak, Dominik Sala, Justyna Kocik, Damian Muszak, Katarzyna Magiera-Mularz
Here, we report a novel class of potent PD-L1/PD-1 inhibitors based on the rigidified biphenyl-inspired structure – terphenyls. Using in-silico docking, we designed and later experimentally shown the efficacy of terphenyl-based scaffolds to inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bbce1028d9973f77ca50e688e6729b
https://doi.org/10.26434/chemrxiv.13849442.v1
https://doi.org/10.26434/chemrxiv.13849442.v1
Autor:
Lukasz Skalniak, Dominik Sala, Alexander Dömling, Justyna Kocik-Krol, Tad A. Holak, Katarzyna Magiera-Mularz, Radoslaw Kitel, Kazimierz Weglarczyk, Jacek Plewka, Damian Muszak, Ewa Surmiak, Małgorzata Stec, Maciej Siedlar, Bogdan Musielak
Publikováno v:
Journal of Medicinal Chemistry, 64(15), 11614-11636. AMER CHEMICAL SOC
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
We describe a new class of potent PD-L1/PD-1 inhibitors based on a terphenyl scaffold that is derived from the rigidified biphenyl-inspired structure. Using in silico docking, we designed and then experimentally demonstrated the effectiveness of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0e35ef9495ca462e48490a926d997d
https://ruj.uj.edu.pl/xmlui/handle/item/277678
https://ruj.uj.edu.pl/xmlui/handle/item/277678
Publikováno v:
Pharmaceuticals, Vol 14, Iss 1079, p 1079 (2021)
Pharmaceuticals
Volume 14
Issue 11
Pharmaceuticals
Volume 14
Issue 11
The pharmacological effects of carbon to silicon bioisosteric replacements have been widely explored in drug design and medicinal chemistry. Here, we present a systematic investigation of the impact of different silyl groups on the anticancer activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f680f3d743c2dadaa4be56b6a7a47586
https://ruj.uj.edu.pl/xmlui/handle/item/285055
https://ruj.uj.edu.pl/xmlui/handle/item/285055