Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Radoslaw Debiec"'
Autor:
Kamlesh Khunti, Azhar Farooqi, Michelle Newton, Riyaz Patel, Vasiliki Bountziouka, Nilesh J Samani, Mayur Lakhani, Andrea Marshall, Radoslaw Debiec, Shireen Kharodia, Daniel Lawday, Emma Beeston, Chris Greengrass, Richard Bramley, Sue Sehmi, Andre Krzeminski, Azhar Zafar, Anuj Chahal, Amardeep Heer, Nitin Joshi
Publikováno v:
BMJ Open, Vol 13, Iss 5 (2023)
Objective The aim of the study was to assess the clinical effectiveness of the national cardiovascular disease (CVD) prevention programme—National Health Service Health Check (NHSHC) in reduction of CVD risk.Design Prospective cohort study.Setting
Externí odkaz:
https://doaj.org/article/dcee14591c77435db6ee2a2e01bb696c
Autor:
Radoslaw Debiec, Stephen E. Hamby, Peter D. Jones, Sue Coolman, Manish Asiani, Shireen Kharodia, Gregory J. Skinner, Nilesh J. Samani, Tom R. Webb, Aidan Bolger
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Abstract Background Bicuspid aortic valve is the most common congenital valvular heart defect in the general population. BAV is associated with significant morbidity due to valve failure, formation of thoracic aortic aneurysm, and increased risk of i
Externí odkaz:
https://doaj.org/article/ac256f24ae524577b9101b1f61cb77f7
Autor:
Giovanni Mariscalco, Radoslaw Debiec, John A. Elefteriades, Nilesh J. Samani, Gavin J. Murphy
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 15 (2018)
Background Nonsyndromic thoracic aortic diseases (NS‐TADs) are often silent entities until they present as life‐threatening emergencies. Despite familial inheritance being common, screening is not the current standard of care in NS‐TADs. We sou
Externí odkaz:
https://doaj.org/article/b3bad9366d0047a093873057a6d3c646
Autor:
Muntaser D Musameh, William Y S Wang, Christopher P Nelson, Carla Lluís-Ganella, Radoslaw Debiec, Isaac Subirana, Roberto Elosua, Anthony J Balmforth, Stephen G Ball, Alistair S Hall, Sekar Kathiresan, John R Thompson, Gavin Lucas, Nilesh J Samani, Maciej Tomaszewski
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117684 (2015)
Only a small fraction of coronary artery disease (CAD) heritability has been explained by common variants identified to date. Interactions between genes of importance to cardiovascular regulation may account for some of the missing heritability of CA
Externí odkaz:
https://doaj.org/article/c10994827fbd4d27a5008208780e37a5
Autor:
Radoslaw Debiec, Paraskevi Christofidou, Matthew Denniff, Lisa D Bloomer, Pawel Bogdanski, Lukasz Wojnar, Katarzyna Musialik, Fadi J Charchar, John R Thompson, Dawn Waterworth, Kijoung Song, Peter Vollenweider, Gerard Waeber, Ewa Zukowska-Szczechowska, Nilesh J Samani, David Lambert, Maciej Tomaszewski
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83137 (2013)
Urotensin-II controls ion/water homeostasis in fish and vascular tone in rodents. We hypothesised that common genetic variants in urotensin-II pathway genes are associated with human blood pressure or renal function. We performed family-based analysi
Externí odkaz:
https://doaj.org/article/d19a12a8e60a4be7a87cbf26b11bfd96
Autor:
Bernhard M Kaess, Maciej Tomaszewski, Peter S Braund, Klaus Stark, Suzanne Rafelt, Marcus Fischer, Robert Hardwick, Christopher P Nelson, Radoslaw Debiec, Fritz Huber, Werner Kremer, Hans Robert Kalbitzer, Lynda M Rose, Daniel I Chasman, Jemma Hopewell, Robert Clarke, Paul R Burton, Martin D Tobin, Christian Hengstenberg, Nilesh J Samani
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14529 (2011)
HDL cholesterol (HDL-C) is an established marker of cardiovascular risk with significant genetic determination. However, HDL particles are not homogenous, and refined HDL phenotyping may improve insight into regulation of HDL metabolism. We therefore
Externí odkaz:
https://doaj.org/article/db13f5b5561b4858acda2f46a8bfd058
Autor:
Jan Gehlen, Anja Stundl, Radoslaw Debiec, Federica Fontana, Markus Krane, Dinara Sharipova, Christopher P Nelson, Baravan Al-Kassou, Ann-Sophie Giel, Jan-Malte Sinning, Christopher M H Bruenger, Carolin F Zelck, Laura L Koebbe, Peter S Braund, Thomas R Webb, Simon Hetherington, Stephan Ensminger, Buntaro Fujita, Salah A Mohamed, Malakh Shrestha, Heike Krueger, Matthias Siepe, Fabian Alexander Kari, Peter Nordbeck, Larissa Buravezky, Malte Kelm, Verena Veulemans, Matti Adam, Stephan Baldus, Karl-Ludwig Laugwitz, Yannick Haas, Matthias Karck, Uwe Mehlhorn, Lars Oliver Conzelmann, Ingo Breitenbach, Corinna Lebherz, Paul Urbanski, Won-Keun Kim, Joscha Kandels, David Ellinghaus, Ulrike Nowak-Goettl, Per Hoffmann, Felix Wirth, Stefanie Doppler, Harald Lahm, Martina Dreßen, Moritz von Scheidt, Katharina Knoll, Thorsten Kessler, Christian Hengstenberg, Heribert Schunkert, Georg Nickenig, Markus M Nöthen, Aidan P Bolger, Salim Abdelilah-Seyfried, Nilesh J Samani, Jeanette Erdmann, Teresa Trenkwalder, Johannes Schumacher
Publikováno v:
Gehlen, J, Stundl, A, Debiec, R, Fontana, F, Krane, M, Sharipova, D, Nelson, C P, Al-Kassou, B, Giel, A S, Sinning, J M, Bruenger, C M H, Zelck, C F, Koebbe, L L, Braund, P S, Webb, T R, Hetherington, S, Ensminger, S, Fujita, B, Mohamed, S A, Shrestha, M, Krueger, H, Siepe, M, Kari, F A, Nordbeck, P, Buravezky, L, Kelm, M, Veulemans, V, Adam, M, Baldus, S, Laugwitz, K L, Haas, Y, Karck, M, Mehlhorn, U, Conzelmann, L O, Breitenbach, I, Lebherz, C, Urbanski, P, Kim, W K, Kandels, J, Ellinghaus, D, Nowak-Goettl, U, Hoffmann, P, Wirth, F, Doppler, S, Lahm, H, Dressen, M, von Scheidt, M, Knoll, K, Kessler, T, Hengstenberg, C, Schunkert, H, Nickenig, G, Noethen, M M, Bolger, A P, Abdelilah-Seyfried, S, Samani, N J, Erdmann, J, Trenkwalder, T & Schumacher, J 2023, ' Elucidation of the genetic causes of bicuspid aortic valve disease ', Cardiovascular Research, vol. 119, no. 3, pp. 857-866 . https://doi.org/10.1093/cvr/cvac099
Aims The present study aims to characterize the genetic risk architecture of bicuspid aortic valve (BAV) disease, the most common congenital heart defect. Methods and results We carried out a genome-wide association study (GWAS) including 2236 BAV pa
Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis
Autor:
Oliver Husser, J. Gustav Smith, Costanza Pellegrini, Viktor Lazovic, Christopher P. Nelson, Lingyao Zeng, Wolfgang Koenig, Kristian Hveem, Adnan Kastrati, Colin N. A. Palmer, Heribert Schunkert, Jesper R. Gådin, Peter S. Braund, Teresa Trenkwalder, Ify R. Mordi, Chim C. Lang, Christian Hengstenberg, Per Eriksson, Radoslaw Debiec, Jonas B. Nielsen, Sarah E. Graham, Thorsten Kessler, Amparo Aracil, Andreas Martinsson, Nilesh J. Samani, Anders Franco-Cereceda, Muntaser D. Musameh, Cristen J. Willer, Tobias Rheude
Publikováno v:
International Journal of Cardiology. 276:212-217
Background Aortic valve stenosis (AVS) and coronary artery disease (CAD) have a significant genetic contribution and commonly co-exist. To compare and contrast genetic determinants of the two diseases, we investigated associations of the LPA and 9p21
Autor:
Gregory J Skinner, Shireen Kharodia, Nilesh J. Samani, Sue Coolman, Peter Jones, Manish Asiani, Tom R. Webb, Aidan Bolger, Stephen E Hamby, Radoslaw Debiec
Publikováno v:
Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Background Bicuspid aortic valve is the most common congenital valvular heart defect in the general population. BAV is associated with significant morbidity due to valve failure, formation of thoracic aortic aneurysm, and increased risk of infective
Publikováno v:
Cardiology in review. 25(4)
Bicuspid aortic valve (BAV) is the most common valvular congenital heart defect in the general population. BAV is commonly associated with the presence of other congenital cardiovascular malformations, which leads to cardiovascular complications requ