Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Radoslav Goldman"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Targeted quantification of glycoproteins has not reached its full potential because of limitations of the existing analytical workflows. In this study, we introduce a targeted microflow LC–MS/MS-PRM method for the quantification of multipl
Externí odkaz:
https://doaj.org/article/e2d85c0463ff47968a6611225e5d0c47
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Carbohydrates form one of the major groups of biological macromolecules in living organisms. Many biological processes including protein folding, stability, immune response, and receptor activation are regulated by glycosylation. Fucosylatio
Externí odkaz:
https://doaj.org/article/36a4944f127b46fbb80e2e4198cbad33
Autor:
Evgenia Gourgari, Junfeng Ma, Martin P. Playford, Nehal N. Mehta, Radoslav Goldman, Alan T. Remaley, Scott M. Gordon
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-11 (2019)
Abstract Background Patients with type 1 diabetes (T1DM) typically have normal or even elevated plasma high density lipoprotein (HDL) cholesterol concentrations; however, HDL protein composition can be altered without a change in cholesterol content.
Externí odkaz:
https://doaj.org/article/8d56b0e3954748eba5bd77b48abdec40
Autor:
Yang Yang, Jaeil Ahn, Rekha Raghunathan, Bhaskar V. Kallakury, Bruce Davidson, Zuzana Brnakova Kennedy, Joseph Zaia, Radoslav Goldman
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Sulfation of heparan sulfate proteoglycans (HSPG) regulates signaling of growth factor receptors via specific interactions with the sulfate groups. 6-O-Sulfation of HSPG is an impactful modification regulated by the activities of dedicated extracellu
Externí odkaz:
https://doaj.org/article/92fd7849509b421b86479f0e80d7c514
Autor:
Alec T McIntosh, Renhuizi Wei, Jaeil Ahn, Brad E Aouizerat, Seble G Kassaye, Michael H Augenbraun, Jennifer C Price, Audrey L French, Stephen J Gange, Kathryn M Anastos, Radoslav Goldman
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247277 (2021)
HIV coinfection is associated with more rapid liver fibrosis progression in hepatitis C (HCV) infection. Recently, much work has been done to improve outcomes of liver disease and to identify targets for pharmacological intervention in coinfected pat
Externí odkaz:
https://doaj.org/article/76f5d8eaaeba46409350200295f520aa
Publikováno v:
Molecules, Vol 27, Iss 7, p 2213 (2022)
Development of high throughput robust methods is a prerequisite for a successful clinical use of LC-MS/MS assays. In earlier studies, we reported that nLC-MS/MS measurement of the O-glycoforms of HPX is an indicator of liver fibrosis. In this study,
Externí odkaz:
https://doaj.org/article/1de20b012f924741807fda46064dbfc1
Autor:
Evgenia Gourgari, Scott Gordon, Junfeng Ma, Martin Playford, Nehal Mehta, Radoslav Goldman, Alan Remaley
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 31-32 (2019)
OBJECTIVES/SPECIFIC AIMS: Our objective was to compare the proteomics of HDL between youth with T1DM and healthy controls (HC). METHODS/STUDY POPULATION: We did chromatography-based HDL purification and SWATH-MS-based proteomic quantitation. Proteomi
Externí odkaz:
https://doaj.org/article/38b5a0a2dd8741cdacc7ae656072e279
Proteome-wide analysis of single-nucleotide variations in the N-glycosylation sequon of human genes.
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36212 (2012)
N-linked glycosylation is one of the most frequent post-translational modifications of proteins with a profound impact on their biological function. Besides other functions, N-linked glycosylation assists in protein folding, determines protein orient
Externí odkaz:
https://doaj.org/article/da40f953626d4ed899d175b99d09eb46
Autor:
Diana Campos, Michael Girgis, Qiang Yang, Guanghui Zong, Radoslav Goldman, Lai-Xi Wang, Miloslav Sanda
Publikováno v:
bioRxiv
Mass spectrometry (MS) can unlock crucial insights into the intricate world of glycosylation analysis. Despite its immense potential, the qualitative and quantitative analysis of isobaric glycopeptide structures remains one of the most daunting hurdl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfeff656220d7e241009683a3ed54f6
https://europepmc.org/articles/PMC10245710/
https://europepmc.org/articles/PMC10245710/
Autor:
Julius Benicky, Miloslav Sanda, Aswini Panigrahi, Jian Liu, Zhangjie Wang, Vijayakanth Pagadala, Guowei Su, Radoslav Goldman
Publikováno v:
Glycobiology.
Sulf-2 is an extracellular heparan 6-O-endosulfatase involved in the postsynthetic editing of heparan sulfate (HS), which regulates many important biological processes. The activity of the Sulf-2 and its substrate specificity remain insufficiently ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11e1c49d6ce99e1de2842ba60d8c201e
https://doi.org/10.1093/glycob/cwad026
https://doi.org/10.1093/glycob/cwad026