Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Radoslav Chayrov"'
Autor:
Kalina Shishkova, Antoniya Stoymirska, Radoslav Chayrov, Stoyan Shishkov, Hristina Sbirkova-Dimitrova, Rusi Rusew, Boris Shivachev, Ivanka Stankova
Publikováno v:
Crystals, Vol 13, Iss 9, p 1374 (2023)
In this study, we utilized the human coronavirus 229E (HCoV-229E) for evaluating the in vitro efficacy of some analogues of the ion-channel inhibitors and Amantadine and Rimantadine. The application of these investigated compounds did not result in a
Externí odkaz:
https://doaj.org/article/516f1ed620574f5dac879abd52ba3d66
Autor:
Radoslav Chayrov, Tatyana Volkova, German Perlovich, Li Zeng, Zhuorong Li, Martin Štícha, Rui Liu, Ivanka Stankova
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1108 (2022)
Glutamate is an excitatory neurotransmitter in the nervous system. Excessive glutamate transmission can lead to increased calcium ion expression, related to increased neurotoxicity. Memantine is used for treating patients with Alzheimer’s disease (
Externí odkaz:
https://doaj.org/article/f2390ac76cec401c803a98b591bd67ac
Autor:
Radoslav Chayrov, Reni Kalfin, Maria Lazarova, Lyubka Tancheva, Hrisitna Sbirkova-Dimitrova, Boris Shivachev, Ivanka Stankova
Publikováno v:
Crystals, Vol 12, Iss 9, p 1227 (2022)
N-methyl-D-aspartate (NMDA) receptor blockade can improve L-DOPA (l-3,4-dihydroxyphenylalanine)-induced dyskinesias in Parkinson’s disease (PD) patients. Amantadine is a well-tolerated and effective antiparkinsonian agent, recently found to possess
Externí odkaz:
https://doaj.org/article/aa04b4119d834e4781c38836035bd667
Autor:
Radoslav Chayrov, Nikolaos A. Parisis, Maria V. Chatziathanasiadou, Eleni Vrontaki, Kalliopi Moschovou, Georgia Melagraki, Hristina Sbirkova-Dimitrova, Boris Shivachev, Michaela Schmidtke, Yavor Mitrev, Martin Sticha, Thomas Mavromoustakos, Andreas G. Tzakos, Ivanka Stankova
Publikováno v:
Molecules, Vol 25, Iss 17, p 3989 (2020)
A series of nineteen amino acid analogues of amantadine (Amt) and rimantadine (Rim) were synthesized and their antiviral activity was evaluated against influenza virus A (H3N2). Among these analogues, the conjugation of rimantadine with glycine illus
Externí odkaz:
https://doaj.org/article/48b8748680a44260baaa42efedc2f8f8
Publikováno v:
Scientia Pharmaceutica, Vol 88, Iss 3, p 38 (2020)
In the present work, the hydrolytic stability of new memantine analogues modified with amino acids, at different pH corresponding to the human biological liquids and organs, was evaluated. Memantine is an uncompetitive N-methyl-d-aspartate receptor a
Externí odkaz:
https://doaj.org/article/1409e71a055443808d915d44324c6504
Publikováno v:
Spectroscopy Letters. 53:489-493
Systematic nuclear magnetic resonance investigation on 12 adamantane amides with potential biological activity is reported. The assignment of proton and carbon-13 chemical shifts shows similar tren...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a3ba030ae46547ffa2af1decf45dde
https://doi.org/10.1080/00387010.2020.1772828
https://doi.org/10.1080/00387010.2020.1772828
Autor:
Albena Alexandrova, A. I. Stoilkova, Ivanka Stankova, Almira Georgieva, Radoslav Chayrov, Elina Tsvetanova
Publikováno v:
Pharmaceutical Chemistry Journal. 54:268-272
Alzheimer’s disease (AD) is the most common type of dementia in elderly. Since oxidative stress is an important feature of AD, it could be assumed that conjugation of the available medicines with substances having antioxidant properties may produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba9aaf8e787d43c133ab4ff4816ad0fb
https://doi.org/10.1007/s11094-020-02189-9
https://doi.org/10.1007/s11094-020-02189-9
Autor:
Anton Hinkov, Ivanka Stankova, Kalina Shishkova, Kiril Chuchkov, Radoslav Chayrov, Daniel Todorov
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 39:979-990
АBSTRACTEsters of the antiherpetic drugs ganciclovir, penciclovir with the bile acids (cholic, chenodeoxycholic and deoxycholic) and amino acid esters of acyclovir were generated and evaluated for their in vitro antiviral activity against herpes sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0310bae5a545fb031582b1f383994289
https://doi.org/10.1080/15257770.2020.1725043
https://doi.org/10.1080/15257770.2020.1725043
Autor:
Maria Lazarova, Lyubka Tancheva, Radoslav Chayrov, Elina Tzvetanova, Albena Alexandrova, Andrey Popatanasov, Diamara Uzunova, Miroslava Stefanova, Ivanka Stankova, Reni Kalfin
The neuroprotective capacity of newly synthesized amantadine derivative tyrosinyl-amantadine (Tyr-Am) with expected antiparkinsonian properties was evaluated in a 6-hydroxydopamine (6-OHDA) model of Parkinson's disease. Male Wistar rats were divided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daae5d3eaa95d00a45d25e3549dd0785
Publikováno v:
Scientia Pharmaceutica, Vol 88, Iss 38, p 38 (2020)
Scientia Pharmaceutica
Volume 88
Issue 3
Scientia Pharmaceutica
Volume 88
Issue 3
In the present work, the hydrolytic stability of new memantine analogues modified with amino acids, at different pH corresponding to the human biological liquids and organs, was evaluated. Memantine is an uncompetitive N-methyl-d-aspartate receptor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e36cac0f2ef62e8afc09185a12fec91
https://www.mdpi.com/2218-0532/88/3/38
https://www.mdpi.com/2218-0532/88/3/38