Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Radoslav, Goldman"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Targeted quantification of glycoproteins has not reached its full potential because of limitations of the existing analytical workflows. In this study, we introduce a targeted microflow LC–MS/MS-PRM method for the quantification of multipl
Externí odkaz:
https://doaj.org/article/e2d85c0463ff47968a6611225e5d0c47
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Carbohydrates form one of the major groups of biological macromolecules in living organisms. Many biological processes including protein folding, stability, immune response, and receptor activation are regulated by glycosylation. Fucosylatio
Externí odkaz:
https://doaj.org/article/36a4944f127b46fbb80e2e4198cbad33
Autor:
Evgenia Gourgari, Junfeng Ma, Martin P. Playford, Nehal N. Mehta, Radoslav Goldman, Alan T. Remaley, Scott M. Gordon
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-11 (2019)
Abstract Background Patients with type 1 diabetes (T1DM) typically have normal or even elevated plasma high density lipoprotein (HDL) cholesterol concentrations; however, HDL protein composition can be altered without a change in cholesterol content.
Externí odkaz:
https://doaj.org/article/8d56b0e3954748eba5bd77b48abdec40
Autor:
Yang Yang, Jaeil Ahn, Rekha Raghunathan, Bhaskar V. Kallakury, Bruce Davidson, Zuzana Brnakova Kennedy, Joseph Zaia, Radoslav Goldman
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Sulfation of heparan sulfate proteoglycans (HSPG) regulates signaling of growth factor receptors via specific interactions with the sulfate groups. 6-O-Sulfation of HSPG is an impactful modification regulated by the activities of dedicated extracellu
Externí odkaz:
https://doaj.org/article/92fd7849509b421b86479f0e80d7c514
Autor:
Alec T McIntosh, Renhuizi Wei, Jaeil Ahn, Brad E Aouizerat, Seble G Kassaye, Michael H Augenbraun, Jennifer C Price, Audrey L French, Stephen J Gange, Kathryn M Anastos, Radoslav Goldman
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247277 (2021)
HIV coinfection is associated with more rapid liver fibrosis progression in hepatitis C (HCV) infection. Recently, much work has been done to improve outcomes of liver disease and to identify targets for pharmacological intervention in coinfected pat
Externí odkaz:
https://doaj.org/article/76f5d8eaaeba46409350200295f520aa
Publikováno v:
Molecules, Vol 27, Iss 7, p 2213 (2022)
Development of high throughput robust methods is a prerequisite for a successful clinical use of LC-MS/MS assays. In earlier studies, we reported that nLC-MS/MS measurement of the O-glycoforms of HPX is an indicator of liver fibrosis. In this study,
Externí odkaz:
https://doaj.org/article/1de20b012f924741807fda46064dbfc1
Autor:
Diana Campos, Michael Girgis, Qiang Yang, Guanghui Zong, Radoslav Goldman, Lai-Xi Wang, Miloslav Sanda
Publikováno v:
bioRxiv
Mass spectrometry (MS) can unlock crucial insights into the intricate world of glycosylation analysis. Despite its immense potential, the qualitative and quantitative analysis of isobaric glycopeptide structures remains one of the most daunting hurdl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfeff656220d7e241009683a3ed54f6
https://europepmc.org/articles/PMC10245710/
https://europepmc.org/articles/PMC10245710/
Autor:
Julius Benicky, Miloslav Sanda, Aswini Panigrahi, Jian Liu, Zhangjie Wang, Vijayakanth Pagadala, Guowei Su, Radoslav Goldman
Publikováno v:
Glycobiology.
Sulf-2 is an extracellular heparan 6-O-endosulfatase involved in the postsynthetic editing of heparan sulfate (HS), which regulates many important biological processes. The activity of the Sulf-2 and its substrate specificity remain insufficiently ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11e1c49d6ce99e1de2842ba60d8c201e
https://doi.org/10.1093/glycob/cwad026
https://doi.org/10.1093/glycob/cwad026
Autor:
Milos V. Novotny, Yehia Mechref, Zuzana Kyselova, Sameera Ezzat, Iman Gouda, Mohamed Abdel-Hamid, Christopher A. Loffredo, Gregory Bascug, Lenka Goldman, Rency S. Varghese, Habtom W. Ressom, Radoslav Goldman
Purpose: Hepatocellular carcinoma (HCC) represents an increasing health problem in the United States. Serum α-fetoprotein, the currently used clinical marker, is elevated in only ∼60% of HCC patients; therefore, the identification of additional ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4fb0c887eb0c7bd48ea612efe2d840
https://doi.org/10.1158/1078-0432.c.6517392
https://doi.org/10.1158/1078-0432.c.6517392
Autor:
Anand Mehta, Radoslav Goldman, Timothy Block, Jorge Marrero, Amit G. Singal, Yuko Kono, Charles Swindell, Harmin Herrera, Mary Ann Comunale, Miloslav Sanda, Mengjun Wang
Supplementary Table S1. Patient Characteristics for patients from the University of California at San Diego; Supplementary Table S2. Fitness of algorithms; Supplementary Table S3. Cross validations of potential models; Supplementary Table S4. Statist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd0ff23c7e8edddcc02828bd212038a
https://doi.org/10.1158/1055-9965.22436380
https://doi.org/10.1158/1055-9965.22436380