Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Radosław P, Nowak"'
Autor:
Charles Zou, Hojong Yoon, Paul M.C. Park, J.J. Patten, Jesse Pellman, Jeannie Carreiro, Jonathan M. Tsai, Yen-Der Li, Shourya S. Roy Burman, Katherine A. Donovan, Jessica Gasser, Adam S. Sperling, Radosław P. Nowak, Eric S. Fischer, Robert A. Davey, Benjamin L. Ebert, Mikołaj Słabicki
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106601- (2023)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks multiple human proteins during infection and viral replication. To examine whether any viral proteins employ human E3 ubiquitin ligases, we evaluated the stability of SARS-
Externí odkaz:
https://doaj.org/article/cb16503b59c14a149316faaa454be17e
Autor:
Jeffrey A. Meyerhardt, Hong Yue, Radosław P. Nowak, Lauren Brais, Chao Ma, Samantha Johnson, Joanna Harrod, Shourya S. Roy Burman, Lynn M. Hendrickson, Stephanie Fischinger, Galit Alter, William Hahn, Bruce E. Johnson, Eric S. Fischer
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
Background The COVID-19 pandemic led to emergency measures to continue patient care and research at a comprehensive cancer center while protecting both employees and patients. Determining exposure and infection rates with SARS-CoV-2 were important to
Externí odkaz:
https://doaj.org/article/98ae7f59ad6b4da28e84d5fb05a13b27
Autor:
Mélissanne de Wispelaere, Guangyan Du, Katherine A. Donovan, Tinghu Zhang, Nicholas A. Eleuteri, Jingting C. Yuan, Joann Kalabathula, Radosław P. Nowak, Eric S. Fischer, Nathanael S. Gray, Priscilla L. Yang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Targeted protein degradation (TPD) is a promising strategy for drug development. In this proof-of-concept study, the authors use telaprevir, which binds hepatitis C virus (HCV) NS3/4A protease, to target the protease for protein degradation, and show
Externí odkaz:
https://doaj.org/article/5d5842f94e6549918072db60b50a3ebb
Autor:
Yang Gao, Baishan Jiang, Hellen Kim, Matthew J. Berberich, Jianwei Che, Katherine A. Donovan, John M. Hatcher, Fidel Huerta, Nicholas P. Kwiatkowski, Yingpeng Liu, Peter P. Liuni, Rebecca J. Metivier, Vineeth K. Murali, Radosław P. Nowak, Tinghu Zhang, Eric S. Fischer, Nathanael S. Gray, Lyn H. Jones
Publikováno v:
Journal of Medicinal Chemistry. 66:5524-5535
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52ba941eed228f45c1fa29dc3785c8d3
https://doi.org/10.1021/acs.jmedchem.2c01864
https://doi.org/10.1021/acs.jmedchem.2c01864
Autor:
Tiffany Tsang, Fidel Huerta, Yingpeng Liu, Jianwei Che, Rebecca J. Metivier, Silas Ferrao, Katherine A. Donovan, Lyn H. Jones, Breanna L. Zerfas, Radosław P. Nowak
Publikováno v:
ACS Chemical Biology. 18:933-941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb1362b76cdb06d7aa3aa5c16b0d7ef8
https://doi.org/10.1021/acschembio.3c00084
https://doi.org/10.1021/acschembio.3c00084
Autor:
Florian Perner, Eytan M. Stein, Daniela V. Wenge, Sukrit Singh, Jeonghyeon Kim, Athina Apazidis, Homa Rahnamoun, Disha Anand, Christian Marinaccio, Charlie Hatton, Yanhe Wen, Richard M. Stone, David Schaller, Shoron Mowla, Wenbin Xiao, Holly A. Gamlen, Aaron J. Stonestrom, Sonali Persaud, Elizabeth Ener, Jevon A. Cutler, John G. Doench, Gerard M. McGeehan, Andrea Volkamer, John D. Chodera, Radosław P. Nowak, Eric S. Fischer, Ross L. Levine, Scott A. Armstrong, Sheng F. Cai
Publikováno v:
Nature. 615:913-919
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::529a1290f87e2b32700e09fe206165c1
https://doi.org/10.1038/s41586-023-05755-9
https://doi.org/10.1038/s41586-023-05755-9
Autor:
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P. Nowak, Thibault Viennet, Esteban A. Orellana, Shourya S. Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S. Fischer, Richard I. Gregory
Publikováno v:
Nature. 613:391-397
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dde4adaaac843561a25cc65c5e66e4db
https://doi.org/10.1038/s41586-022-05566-4
https://doi.org/10.1038/s41586-022-05566-4
Autor:
Nicholas M. Pearce, Tobias Krojer, Anthony R. Bradley, Patrick Collins, Radosław P. Nowak, Romain Talon, Brian D. Marsden, Sebastian Kelm, Jiye Shi, Charlotte M. Deane, Frank von Delft
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Building a ligand into a weak region of an electron density map of a protein is a subjective process. Here, the authors present a new method to obtain a clear electron density for a bound ligand based on multi-crystal experiments and 3D background co
Externí odkaz:
https://doaj.org/article/c88bb825cf794f33ac6c39f01dd123b7
Autor:
Mingxing Teng, Jie Jiang, Eric S. Wang, Qixiang Geng, Sean T. Toenjes, Katherine A. Donovan, Nada Mageed, Hong Yue, Radosław P. Nowak, Jinhua Wang, Theresa D. Manz, Eric S. Fischer, Lewis C. Cantley, Nathanael S. Gray
Publikováno v:
Angewandte Chemie. 135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b408266723f5dba53f83c5d9fdb514
https://doi.org/10.1002/ange.202302364
https://doi.org/10.1002/ange.202302364
Autor:
Ivana Gasic, Brian J. Groendyke, Radosław P. Nowak, J. Christine Yuan, Joann Kalabathula, Eric S. Fischer, Nathanael S. Gray, Timothy J. Mitchison
Publikováno v:
Cells, Vol 9, Iss 5, p 1083 (2020)
Dysregulation of microtubules and tubulin homeostasis has been linked to developmental disorders, neurodegenerative diseases, and cancer. In general, both microtubule-stabilizing and destabilizing agents have been powerful tools for studies of microt
Externí odkaz:
https://doaj.org/article/8f2efcf24a734af485421f5c3d76b50b