Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Radomir Kratchmarov"'
Publikováno v:
Blood Advances, Vol 2, Iss 14, Pp 1685-1690 (2018)
Abstract: Expression of the transcription factor T-cell factor 1 (TCF1) identifies antigen-experienced murine CD8+ T cells that retain potential for lymphoid recirculation and the ability to self-renew while producing more differentiated effector cel
Externí odkaz:
https://doaj.org/article/70f61d26b192483f8eb9ca3111db9cb8
Autor:
Yen-Hua Chen, Radomir Kratchmarov, Wen-Hsuan W. Lin, Nyanza J. Rothman, Bonnie Yen, William C. Adams, Simone A. Nish, Jeffrey C. Rathmell, Steven L. Reiner
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 860-868 (2018)
Unequal transmission of nutritive signaling during cell division establishes fate disparity between sibling lymphocytes, but how asymmetric signaling becomes organized is not understood. We show that receptor-associated class I phosphatidylinositol 3
Externí odkaz:
https://doaj.org/article/7461fd78f1ed4b0c926b4242d57a9d12
Autor:
William C. Adams, Yen-Hua Chen, Radomir Kratchmarov, Bonnie Yen, Simone A. Nish, Wen-Hsuan W. Lin, Nyanza J. Rothman, Larry L. Luchsinger, Ulf Klein, Meinrad Busslinger, Jeffrey C. Rathmell, Hans-Willem Snoeck, Steven L. Reiner
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3142-3152 (2016)
Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria. Disparate mitochondrial clearance impacts cell fate and reflects larger constellations of op
Externí odkaz:
https://doaj.org/article/5bde382393f64c32b1a85536f31cbaa6
Autor:
Wen-Hsuan W. Lin, Simone A. Nish, Bonnie Yen, Yen-Hua Chen, William C. Adams, Radomir Kratchmarov, Nyanza J. Rothman, Avinash Bhandoola, Hai-Hui Xue, Steven L. Reiner
Publikováno v:
Cell Reports, Vol 17, Iss 7, Pp 1773-1782 (2016)
Selected CD8+ T cells must divide, produce differentiated effector cells, and self-renew, often repeatedly. We now show that silencing expression of the transcription factor TCF1 marks loss of self-renewal by determined effector cells and that this r
Externí odkaz:
https://doaj.org/article/15543fb84dbf457b819749ecac5306c8
Autor:
Wen-Hsuan W. Lin, William C. Adams, Simone A. Nish, Yen-Hua Chen, Bonnie Yen, Nyanza J. Rothman, Radomir Kratchmarov, Takaharu Okada, Ulf Klein, Steven L. Reiner
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2203-2218 (2015)
Metazoan sibling cells often diverge in activity and identity, suggesting links between growth signals and cell fate. We show that unequal transduction of nutrient-sensitive PI3K/AKT/mTOR signaling during cell division bifurcates transcriptional netw
Externí odkaz:
https://doaj.org/article/14178e8238a842baa15557f6ad3eeaef
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58776 (2013)
Alphaherpes viruses, such as pseudorabies virus (PRV), undergo anterograde transport in neuronal axons to facilitate anterograde spread within hosts. Axonal sorting and anterograde transport of virions is dependent on the viral membrane protein Us9,
Externí odkaz:
https://doaj.org/article/efd481571ef544b8bd80a80ec8db37d2
Autor:
Rohan Maniar, Peter H. Wang, Robert S. Washburn, Radomir Kratchmarov, Shana M. Coley, Anjali Saqi, Samuel S. Pan, Jianhua Hu, Catherine A. Shu, Naiyer A. Rizvi, Brian S. Henick, Steven L. Reiner
Publikováno v:
Cancer Immunology Research. 11:164-170
Treatment with immune checkpoint blockade (ICB) often fails to elicit durable antitumor immunity. Recent studies suggest that ICB does not restore potency to terminally dysfunctional T cells, but instead drives proliferation and differentiation of se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cda77ed1ac40596d04a2c0e27f6c21
https://doi.org/10.1158/2326-6066.cir-22-0524
https://doi.org/10.1158/2326-6066.cir-22-0524
Autor:
Peter H. Wang, Robert Washburn, Rohan Maniar, Michael Mu, Olivia Ringham, Radomir Kratchmarov, Brian S. Henick, Steven L. Reiner
Publikováno v:
The Journal of Immunology. 209:660-664
Immune checkpoint blockade is limited by resistance to treatment, with many patients not achieving durable antitumor responses. Self-renewing (T cell factor 1+ [TCF1+]) CD8+ T cells have recently been implicated in efficacy of anti–programmed cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34c86132e1c6615de579e9721755bb37
https://doi.org/10.4049/jimmunol.2200317
https://doi.org/10.4049/jimmunol.2200317
Autor:
Steven L. Reiner, Brian S. Henick, Naiyer A. Rizvi, Catherine A. Shu, Jianhua Hu, Samuel S. Pan, Anjali Saqi, Shana M. Coley, Radomir Kratchmarov, Robert S. Washburn, Peter H. Wang, Rohan Maniar
Treatment with immune checkpoint blockade (ICB) often fails to elicit durable antitumor immunity. Recent studies suggest that ICB does not restore potency to terminally dysfunctional T cells, but instead drives proliferation and differentiation of se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205541e698e36bde1d39f50309e8cd70
https://doi.org/10.1158/2326-6066.c.6551126
https://doi.org/10.1158/2326-6066.c.6551126
Autor:
Steven L. Reiner, Brian S. Henick, Naiyer A. Rizvi, Catherine A. Shu, Jianhua Hu, Samuel S. Pan, Anjali Saqi, Shana M. Coley, Radomir Kratchmarov, Robert S. Washburn, Peter H. Wang, Rohan Maniar
Supplementary Figs. S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c702e7138cc336dde49ac466e3d9285
https://doi.org/10.1158/2326-6066.22546226.v1
https://doi.org/10.1158/2326-6066.22546226.v1