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Susceptibility of Toxoplasma gondii to autophagy in human cells relies on multiple interacting parasite loci.

Autor: Rinkenberger N; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA., Rosenberg A; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA., Radke JB; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA., Bhushan J; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA., Tomita T; Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA., Weiss LM; Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA., Sibley LD; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA.

Publikováno v: MBio [mBio] 2024 Jan 16; Vol. 15 (1), pp. e0259523. Date of Electronic Publication: 2023 Dec 14.

Flecainide poisoning and prolongation of elimination due to alkalinization.

Autor: McCabe DJ; Division of Medical Toxicology, Department of Emergency Medicine, University of Iowa, Iowa City, IA, United States of America; Iowa Poison Control Center, Sioux City, IA, United States of America. Electronic address: daniel-j-mccabe@uiowa.edu., Walsh RD; Department of Emergency Medicine, University of Iowa, Iowa City, IA, United States of America., Georgakakos PK; Department of Emergency Medicine, University of Iowa, Iowa City, IA, United States of America., Radke JB; Division of Medical Toxicology, Department of Emergency Medicine, University of Iowa, Iowa City, IA, United States of America; Iowa Poison Control Center, Sioux City, IA, United States of America., Wilson BZ; Division of Medical Toxicology, Department of Emergency Medicine, University of Iowa, Iowa City, IA, United States of America; Iowa Poison Control Center, Sioux City, IA, United States of America.

Publikováno v: The American journal of emergency medicine [Am J Emerg Med] 2022 Jun; Vol. 56, pp. 394.e1-394.e4. Date of Electronic Publication: 2022 Mar 09.

Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase.

Autor: Radke JB; Department of Molecular Microbiology, Washington University Sch. Med., St Louis, MO, 63110, USA., Melillo B; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, 02142, USA., Mittal P; Molecular Medicine-Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India.; National Institute of Malaria Research, New Delhi, 110077, India., Sharma M; Molecular Medicine-Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India., Sharma A; Molecular Medicine-Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India.; National Institute of Malaria Research, New Delhi, 110077, India., Fu Y; Department of Molecular Microbiology, Washington University Sch. Med., St Louis, MO, 63110, USA., Uddin T; Department of Molecular Microbiology, Washington University Sch. Med., St Louis, MO, 63110, USA., Gonse A; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, 02142, USA., Comer E; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, 02142, USA., Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA., Gupta AK; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Calibr at Scripps Research, La Jolla, CA, 92037, USA., Chatterjee AK; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Calibr at Scripps Research, La Jolla, CA, 92037, USA., Sibley LD; Department of Molecular Microbiology, Washington University Sch. Med., St Louis, MO, 63110, USA. sibley@wustl.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Jan 24; Vol. 13 (1), pp. 459. Date of Electronic Publication: 2022 Jan 24.