Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Radka Vaclavikova"'
Autor:
Tomas Sychra, Alzbeta Spalenkova, Stepan Balatka, Radka Vaclavikova, Karolina Seborova, Marie Ehrlichova, Jaroslav Truksa, Cristian Sandoval-Acuña, Vlasta Nemcova, Arpad Szabo, Kamila Koci, Tereza Tesarova, Lei Chen, Iwao Ojima, Martin Oliverius, Pavel Soucek
Publikováno v:
iScience, Vol 27, Iss 2, Pp 109044- (2024)
Summary: Pancreatic cancer is a severe malignancy with increasing incidence and high mortality due to late diagnosis and low sensitivity to treatments. Search for the most appropriate drugs and therapeutic regimens is the most promising way to improv
Externí odkaz:
https://doaj.org/article/a032fb8b23884f2993b71832d334ba03
Autor:
Filip Ambrozkiewicz, Andriy Trailin, Lenka Červenková, Radka Vaclavikova, Vojtech Hanicinec, Mohammad Al Obeed Allah, Richard Palek, Vladislav Třeška, Ondrej Daum, Zbyněk Tonar, Václav Liška, Kari Hemminki
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Hepatocellular carcinoma (HCC) is a fatal disease characterized by early genetic alterations in telomerase reverse transcriptase promoter (TERTp) and β-catenin (CTNNB1) genes and immune cell activation in the tumor microenvironme
Externí odkaz:
https://doaj.org/article/6a29246f9dcd4a1a865602138a1f4df2
Autor:
Karolina Seborova, Viktor Hlavac, Petr Holy, Sunniva S. Bjørklund, Thomas Fleischer, Lukas Rob, Martin Hruda, Jiri Bouda, Marcela Mrhalova, Mohammad Moufaq Khatar Al Obeed Allah, Pavel Vodicka, Ondrej Fiala, Pavel Soucek, Vessela N. Kristensen, Ludmila Vodickova, Radka Vaclavikova
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Epithelial ovarian carcinoma (EOC) is known for high mortality due to diagnosis at advanced stages and frequent therapy resistance. Previous findings suggested that the DNA repair system is involved in the therapeutic response of cancer patients and
Externí odkaz:
https://doaj.org/article/4d3c2d1b733a4311bfac5bc44475ebba
Autor:
Karolina Seborova, Kamila Koucka, Alzbeta Spalenkova, Petr Holy, Marie Ehrlichova, Tomas Sychra, Lei Chen, Hersh Bendale, Iwao Ojima, Cristian Sandoval-Acuña, Jaroslav Truksa, Pavel Soucek, Radka Vaclavikova
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Taxanes are widely used in the treatment of ovarian carcinomas. One of the main problems with conventional taxanes is the risk of development of multidrug resistance. New-generation synthetic experimental taxoids (Stony Brook Taxanes; SB-T) have show
Externí odkaz:
https://doaj.org/article/40f498fcbaef46a1889e236533885e53
Autor:
Sona Hubackova, Miroslav Pribyl, Lenka Kyjacova, Alena Moudra, Rastislav Dzijak, Barbora Salovska, Hynek Strnad, Vojtech Tambor, Terezie Imrichova, Jiri Svec, Pavel Vodicka, Radka Vaclavikova, Lukas Rob, Jiri Bartek, Zdenek Hodny
Publikováno v:
Molecular Oncology, Vol 13, Iss 7, Pp 1467-1489 (2019)
Radiation and chemotherapy represent standard‐of‐care cancer treatments. However, most patients eventually experience tumour recurrence, treatment failure and metastatic dissemination with fatal consequences. To elucidate the molecular mechanisms
Externí odkaz:
https://doaj.org/article/245b820657594210941ebc8f6ccbec17
Autor:
Karolina Seborova, Radka Vaclavikova, Pavel Soucek, Katerina Elsnerova, Alena Bartakova, Petr Cernaj, Jiri Bouda, Lukas Rob, Martin Hruda, Pavel Dvorak
Publikováno v:
Cancer Medicine, Vol 8, Iss 2, Pp 606-616 (2019)
Abstract Introduction Ovarian cancer (OC) represents a serious disease with high mortality and lack of efficient predictive and prognostic biomarkers. ATP‐binding cassette (ABC) proteins constitute a large family dedicated to active transmembrane t
Externí odkaz:
https://doaj.org/article/4226b8e44ddc49938d5292df14cafd04
Autor:
Karolina Seborova, Alzbeta Kloudova-Spalenkova, Kamila Koucka, Petr Holy, Marie Ehrlichova, Changwei Wang, Iwao Ojima, Iveta Voleska, Petr Daniel, Kamila Balusikova, Michael Jelinek, Jan Kovar, Lukas Rob, Martin Hruda, Marcela Mrhalova, Pavel Soucek, Radka Vaclavikova
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 73 (2021)
The main problem precluding successful therapy with conventional taxanes is de novo or acquired resistance to taxanes. Therefore, novel experimental taxane derivatives (Stony Brook taxanes; SB-Ts) are synthesized and tested as potential drugs against
Externí odkaz:
https://doaj.org/article/77ee0bd6371147ae89d6f2ac8ee5c1f2
Publikováno v:
Cancers, Vol 13, Iss 8, p 1839 (2021)
Ovarian cancer is one of the most common causes of death among gynecological malignancies. Molecular changes occurring in the primary tumor lead to metastatic spread into the peritoneum and the formation of distant metastases. Identification of these
Externí odkaz:
https://doaj.org/article/77ccd5f684bf466583dd173d9e888bc3
Autor:
Kristyna Tomasova, Andrea Cumova, Karolina Seborova, Josef Horak, Kamila Koucka, Ludmila Vodickova, Radka Vaclavikova, Pavel Vodicka
Publikováno v:
Cancers, Vol 12, Iss 7, p 1713 (2020)
There is ample evidence for the essential involvement of DNA repair and DNA damage response in the onset of solid malignancies, including ovarian cancer. Indeed, high-penetrance germline mutations in DNA repair genes are important players in familial
Externí odkaz:
https://doaj.org/article/e82ba3a63f344ec0bbecfe9992fc95ea
Autor:
Viktor Hlavac, Maria Kovacova, Katerina Elsnerova, Veronika Brynychova, Renata Kozevnikovova, Karel Raus, Katerina Kopeckova, Sona Mestakova, David Vrana, Jiri Gatek, Pavel Ostasov, Radka Vaclavikova, Pavel Soucek
Publikováno v:
Cancers, Vol 10, Iss 12, p 511 (2018)
The aim of our study was to set up a panel for targeted sequencing of chemoresistance genes and the main transcription factors driving their expression and to evaluate their predictive and prognostic value in breast cancer patients. Coding and regula
Externí odkaz:
https://doaj.org/article/427183575b1b4106b3a9a4b8ccc9c89a