Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Radka Michalkova"'
Autor:
Radka Michalkova, Ladislav Mirossay, Martin Kello, Gabriela Mojzisova, Janette Baloghova, Anna Podracka, Jan Mojzis
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10354 (2023)
There is no doubt that significant progress has been made in tumor therapy in the past decades. However, the discovery of new molecules with potential antitumor properties still remains one of the most significant challenges in the field of anticance
Externí odkaz:
https://doaj.org/article/e633fa2635e74186b145221411c8ddfa
Autor:
Marianna, Budovska1 (AUTHOR), Radka, Michalkova2 (AUTHOR), Martin, Kello2 (AUTHOR), Janka, Vaskova3 (AUTHOR), Jan, Mojzis2 (AUTHOR) jan.mojzis@upjs.sk
Publikováno v:
Molecules. Jan2023, Vol. 28 Issue 1, p251. 19p.
Autor:
Radka Michalkova, Martin Kello, Martina Cizmarikova, Annamaria Bardelcikova, Ladislav Mirossay, Jan Mojzis
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5964 (2023)
Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers with a high incidence rate worldwide. The current treatment including surgery, chemotherapy or radiotherapy has several limitations such as drug toxicity, cancer re
Externí odkaz:
https://doaj.org/article/775e2edffc94443296805d989ba99224
Publikováno v:
Molecules, Vol 28, Iss 1, p 251 (2022)
This work deals with the study of the synthesis of new bis-indole analogues with a phenyl linker derived from indole phytoalexins. Synthesis of target bis-indole thiourea linked by a phenyl linker was achieved by the reaction of [1-(tert-butoxycarbon
Externí odkaz:
https://doaj.org/article/0aa5a1d1dc014509b5b2fef3b88fb5e3
Autor:
Maria Gazdova, Radka Michalkova, Martin Kello, Maria Vilkova, Zuzana Kudlickova, Janette Baloghova, Ladislav Mirossay, Jan Mojzis
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12266 (2022)
This study was focused on investigating the antiproliferative effects of chalcone hybrids in melanoma cancer cells. Among seven chalcone hybrids, the chalcone-acridine hybrid 1C was the most potent and was selected for further antiproliferative mecha
Externí odkaz:
https://doaj.org/article/d9460624bc2c47a4b76a9623fe4ca2f0
Autor:
Radka Michalkova, Martin Kello, Zuzana Kudlickova, Maria Gazdova, Ladislav Mirossay, Gabriela Mojzisova, Jan Mojzis
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 503 (2022)
Although new chemotherapy significantly increased the survival of breast cancer (BC) patients, the use of these drugs is often associated with serious toxicity. The discovery of novel anticancer agents for BC therapy is expected. This study was condu
Externí odkaz:
https://doaj.org/article/4ee940a16baa47fabf8e4f3b74d020e1
Publikováno v:
Cancers, Vol 13, Iss 11, p 2730 (2021)
Although great progress has been made in the treatment of cancer, the search for new promising molecules with antitumor activity is still one of the greatest challenges in the fight against cancer due to the increasing number of new cases each year.
Externí odkaz:
https://doaj.org/article/2bddc990259a450081fd1ae1c87d5dba
Autor:
Peter Takac, Martin Kello, Maria Vilkova, Janka Vaskova, Radka Michalkova, Gabriela Mojzisova, Jan Mojzis
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 345 (2020)
Chalcones are naturally occurring phytochemicals with diverse biological activities including antioxidant, antiproliferative, and anticancer effects. Some studies indicate that the antiproliferative effect of chalcones may be associated with their pr
Externí odkaz:
https://doaj.org/article/63d19af5e3c340438d64a9328cc88dfa
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 151:1737-1758
The increasing diversity of small molecule libraries is a major source for the discovery of new drug candidates. In terms of this trend, we report the synthesis of five series 5-bromosubstituted derivatives of indole phytoalexins Types A–E using a
Publikováno v:
Cancers
Cancers, Vol 13, Iss 2730, p 2730 (2021)
Cancers, Vol 13, Iss 2730, p 2730 (2021)
Simple Summary Despite the important progress in cancer treatment in the past decades, the mortality rates in some types of cancer have not significantly decreased. Therefore, the search for novel anticancer drugs has become a topic of great interest