Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Radim Osicka"'
Autor:
Yifan Wu, Shuqi Du, Lynn H. Bimler, Kelsey E. Mauk, Léa Lortal, Nessim Kichik, James S. Griffiths, Radim Osicka, Lizhen Song, Katherine Polsky, Lydia Kasper, Peter Sebo, Jill Weatherhead, J. Morgan Knight, Farrah Kheradmand, Hui Zheng, Jonathan P. Richardson, Bernhard Hube, Julian R. Naglik, David B. Corry
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113240- (2023)
Summary: The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer’s disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blo
Externí odkaz:
https://doaj.org/article/c973f39dfee7477fac57548342be679b
Autor:
Frantisek Spoutil, Goretti Aranaz-Novaliches, Michaela Prochazkova, Tomas Wald, Vendula Novosadova, Petr Kasparek, Radim Osicka, Janne E. Reseland, Staale P. Lyngstadaas, Hanna Tiainen, Kristyna Bousova, Jiri Vondrasek, Radislav Sedlacek, Jan Prochazka
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in odontogenic tissues and diverged from common ancestral gene. They are crucial for the maturation of enamel and its extreme complexity in multiple independent lin
Externí odkaz:
https://doaj.org/article/9cee86c6099c4e5593b71dbfde9ce7ab
Autor:
Anna Lepesheva, Adriana Osickova, Jana Holubova, David Jurnecka, Sarka Knoblochova, Carlos Espinosa-Vinals, Ladislav Bumba, Karolina Skopova, Radovan Fiser, Radim Osicka, Peter Sebo, Jiri Masin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Pore-forming repeats in toxins (RTX) are key virulence factors of many Gram-negative pathogens. We have recently shown that the aromatic side chain of the conserved tyrosine residue 940 within the acylated segment of the RTX adenylate cyclas
Externí odkaz:
https://doaj.org/article/6f873568b2e4490a9da5948d8fb80b36
Autor:
Maryam Golshani, Waheed Ur Rahman, Adriana Osickova, Jana Holubova, Jinery Lora, Nataliya Balashova, Peter Sebo, Radim Osicka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12598 (2022)
The pertussis agent Bordetella pertussis produces a number of virulence factors, of which the filamentous hemagglutinin (FhaB) plays a role in B. pertussis adhesion to epithelial and phagocytic cells. Moreover, FhaB was recently found to play a cruci
Externí odkaz:
https://doaj.org/article/e23a5aa7fd7d40388b6390cfea172099
Publikováno v:
Microorganisms, Vol 10, Iss 3, p 518 (2022)
The Gram-negative bacterium Kingella kingae is part of the commensal oropharyngeal flora of young children. As detection methods have improved, K. kingae has been increasingly recognized as an emerging invasive pathogen that frequently causes skeleta
Externí odkaz:
https://doaj.org/article/a4d26f7dd19d4b839a9d67630e4cba84
Autor:
Adriana Osickova, Nataliya Balashova, Jiri Masin, Miroslav Sulc, Jana Roderova, Tomas Wald, Angela C. Brown, Evan Koufos, En Hyung Chang, Alexander Giannakakis, Edward T. Lally, Radim Osicka
Publikováno v:
Emerging Microbes and Infections, Vol 7, Iss 1, Pp 1-15 (2018)
Abstract Kingella kingae is a member of the commensal oropharyngeal flora of young children. Improvements in detection methods have led to the recognition of K. kingae as an emerging pathogen that frequently causes osteoarticular infections in childr
Externí odkaz:
https://doaj.org/article/0ad24cd2bb474f8e83870cb95223ed73
Autor:
Jana Holubova, Attila Juhasz, Jiri Masin, Ondrej Stanek, David Jurnecka, Adriana Osickova, Peter Sebo, Radim Osicka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11655 (2021)
The whooping cough agent, Bordetella pertussis, secretes an adenylate cyclase toxin–hemolysin (CyaA, ACT, or AC-Hly) that catalyzes the conversion of intracellular ATP to cAMP and through its signaling annihilates the bactericidal activities of hos
Externí odkaz:
https://doaj.org/article/0803fecdd7814728ba5514a977f1ed41
Autor:
Anna Malandra, Waheed Ur Rahman, Nela Klimova, Gaia Streparola, Jana Holubova, Adriana Osickova, Simone Bariselli, Peter Sebo, Radim Osicka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 9064 (2021)
The mucus layer protects airway epithelia from damage by noxious agents. Intriguingly, Bordetella pertussis bacteria provoke massive mucus production by nasopharyngeal epithelia during the initial coryza-like catarrhal stage of human pertussis and th
Externí odkaz:
https://doaj.org/article/c8c7de1cdf384ae88be2fb1d02340f98
Publikováno v:
Diagnostics, Vol 11, Iss 2, p 180 (2021)
Serological diagnosis of pertussis is mainly based on anti-pertussis toxin (PT) IgG antibodies. Since PT is included in all acellular vaccines (ACV), serological assays do not differentiate antibodies induced by ACVs and infection. Adenylate cyclase
Externí odkaz:
https://doaj.org/article/b086585094704897b9fa5294078f6ed1
Autor:
Waheed Ur Rahman, Adriana Osickova, Nela Klimova, Jinery Lora, Nataliya Balashova, Radim Osicka
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9092 (2020)
The Gram-negative coccobacillus Kingella kingae is increasingly recognized as an important invasive pediatric pathogen that causes mostly bacteremia and skeletal system infections. K. kingae secretes an RtxA toxin that belongs to a broad family of th
Externí odkaz:
https://doaj.org/article/a73ed197928f448db51205bb018adf4a