Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Radim Osička"'
Autor:
Milan Kuchař, Kristýna Sloupenská, Leona Rašková Kafková, Yaroslava Groza, Jozef Škarda, Petr Kosztyu, Marie Hlavničková, Joanna M. Mierzwicka, Radim Osička, Hana Petroková, Stephen I. Walimbwa, Shiv Bharadwaj, Jiří Černý, Milan Raška, Petr Malý
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Human interleukin-22 (IL-22) is known as a “dual function” cytokine that acts as a master regulator to maintain homeostasis, structural integrity of the intestinal epithelial barrier, and shielding against bacterial pathogens.
Externí odkaz:
https://doaj.org/article/7572fe8ba3d04303a546ae87cac08392
Autor:
Yaroslava Groza, Lukáš Lacina, Milan Kuchař, Leona Rašková Kafková, Kateřina Zachová, Olga Janoušková, Radim Osička, Jiří Černý, Hana Petroková, Joanna Maria Mierzwicka, Natalya Panova, Petr Kosztyu, Kristýna Sloupenská, Jan Malý, Jozef Škarda, Milan Raška, Karel Smetana, Petr Malý
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Background Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune diseases. Signaling via its cognate IL-6 receptor (IL-6R) complex is critical i
Externí odkaz:
https://doaj.org/article/60f3248bbe5d4cae877f072b508159d0
Autor:
Lucie Křížová, Milan Kuchař, Hana Petroková, Radim Osička, Marie Hlavničková, Ondřej Pelák, Jiří Černý, Tomáš Kalina, Petr Malý
Publikováno v:
Autoimmunity, Vol 50, Iss 2, Pp 102-113 (2017)
Interleukin-23 (IL-23), a heterodimeric cytokine of covalently bound p19 and p40 proteins, has recently been closely associated with development of several chronic autoimmune diseases such as psoriasis, psoriatic arthritis or inflammatory bowel disea
Externí odkaz:
https://doaj.org/article/ec7241e9efe242d1becf311b27bdd427
Autor:
Marie Hlavničková, Milan Kuchař, Radim Osička, Lucie Vaňková, Hana Petroková, Michal Malý, Jiří Černý, Petr Arenberger, Petr Malý
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 3089 (2018)
Interleukin 17 (IL-17) and its cognate receptor A (IL-17RA) play a crucial role in Th17 cells-mediated pro-inflammatory pathway and pathogenesis of several autoimmune disorders including psoriasis. IL-17 is mainly produced by activated Th-17 helper c
Externí odkaz:
https://doaj.org/article/ed479f3c9429488a9dddbbfef8b0e86e
Autor:
Yifan Wu, Shuqi Du, Lynn H. Bimler, Kelsey E. Mauk, Léa Lortal, Nessim Kichik, James S. Griffiths, Radim Osicka, Lizhen Song, Katherine Polsky, Lydia Kasper, Peter Sebo, Jill Weatherhead, J. Morgan Knight, Farrah Kheradmand, Hui Zheng, Jonathan P. Richardson, Bernhard Hube, Julian R. Naglik, David B. Corry
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113240- (2023)
Summary: The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer’s disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blo
Externí odkaz:
https://doaj.org/article/c973f39dfee7477fac57548342be679b
Autor:
Frantisek Spoutil, Goretti Aranaz-Novaliches, Michaela Prochazkova, Tomas Wald, Vendula Novosadova, Petr Kasparek, Radim Osicka, Janne E. Reseland, Staale P. Lyngstadaas, Hanna Tiainen, Kristyna Bousova, Jiri Vondrasek, Radislav Sedlacek, Jan Prochazka
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in odontogenic tissues and diverged from common ancestral gene. They are crucial for the maturation of enamel and its extreme complexity in multiple independent lin
Externí odkaz:
https://doaj.org/article/9cee86c6099c4e5593b71dbfde9ce7ab
Autor:
Anna Lepesheva, Adriana Osickova, Jana Holubova, David Jurnecka, Sarka Knoblochova, Carlos Espinosa-Vinals, Ladislav Bumba, Karolina Skopova, Radovan Fiser, Radim Osicka, Peter Sebo, Jiri Masin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Pore-forming repeats in toxins (RTX) are key virulence factors of many Gram-negative pathogens. We have recently shown that the aromatic side chain of the conserved tyrosine residue 940 within the acylated segment of the RTX adenylate cyclas
Externí odkaz:
https://doaj.org/article/6f873568b2e4490a9da5948d8fb80b36
Autor:
Tomáš, Wald, Lucie, Bednárová, Radim, Osička, Petr, Pachl, Miroslav, Sulc, Stale Petter, Lyngstadaas, Ivan, Slaby, Jiří, Vondrášek
Publikováno v:
European journal of oral sciences. 119
Ameloblastin (AMBN) is a protein expressed mainly during dental hard tissue development. Biochemically, it is classified as an intrinsically disordered protein (IDP). Its biological role remains largely unknown; however, the question of AMBN function
Autor:
Maryam Golshani, Waheed Ur Rahman, Adriana Osickova, Jana Holubova, Jinery Lora, Nataliya Balashova, Peter Sebo, Radim Osicka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12598 (2022)
The pertussis agent Bordetella pertussis produces a number of virulence factors, of which the filamentous hemagglutinin (FhaB) plays a role in B. pertussis adhesion to epithelial and phagocytic cells. Moreover, FhaB was recently found to play a cruci
Externí odkaz:
https://doaj.org/article/e23a5aa7fd7d40388b6390cfea172099
Autor:
Adriana Osickova, Nataliya Balashova, Jiri Masin, Miroslav Sulc, Jana Roderova, Tomas Wald, Angela C. Brown, Evan Koufos, En Hyung Chang, Alexander Giannakakis, Edward T. Lally, Radim Osicka
Publikováno v:
Emerging Microbes and Infections, Vol 7, Iss 1, Pp 1-15 (2018)
Abstract Kingella kingae is a member of the commensal oropharyngeal flora of young children. Improvements in detection methods have led to the recognition of K. kingae as an emerging pathogen that frequently causes osteoarticular infections in childr
Externí odkaz:
https://doaj.org/article/0ad24cd2bb474f8e83870cb95223ed73