Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Radim, Havelek"'
Autor:
Barbora Vítovcová, Veronika Skarková, Radim Havelek, Jiří Soukup, Ananya Pande, Kateřina Caltová, Emil Rudolf
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Glioblastoma multiforme (GBM) belongs to most aggressive and invasive primary brain tumor in adults whose prognosis and survival remains poor. Potential new treatment modalities include targeting the cytoskeleton. In our study, we demonstrat
Externí odkaz:
https://doaj.org/article/c47cc9fa09f44377be5987321e1967de
Autor:
Darja Koutova, Negar Maafi, Darina Muthna, Karel Kralovec, Jana Kroustkova, Filip Pidany, Abdul Aziz Timbilla, Eva Cermakova, Lucie Cahlikova, Martina Rezacova, Radim Havelek
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115295- (2023)
The isoquinoline alkaloids found in Amaryllidaceae are attracting attention due to attributes that can be harnessed for the development of new drugs. The possible molecular mechanisms by which montanine exerts its inhibitory effects against cancer ce
Externí odkaz:
https://doaj.org/article/c11113fffb95455babc5daa1d760bada
Autor:
Aneta Ritomská, Darja Koutova, Jana Křoustková, Karel Královec, Darina Muthná, Jiří Kuneš, Lucie Nováková, Radim Havelek, Lucie Cahlíková
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 8, Pp 101684- (2023)
Ambelline, an alkaloid from the Amaryllidaceae family with a crinane-type skeleton, has not yet demonstrated any outstanding biological activity. However, its analogues prepared by derivatization of the C-11 hydroxyl group show different interesting
Externí odkaz:
https://doaj.org/article/a801666b7a734259b25a002e2f54f0aa
Autor:
Katarina Tripska, Ivone Cristina Igreja Sá, Martina Vasinova, Matej Vicen, Radim Havelek, Samira Eissazadeh, Zuzana Svobodova, Barbora Vitverova, Charles Theuer, Carmelo Bernabeu, Petr Nachtigal
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Endoglin (Eng) is a co-receptor of the transforming growth factor β superfamily playing an important role in endothelial dysfunction. TRC105 (carotuximab) is a monoclonal antibody that blocks Eng and its downstream Smad signaling pathway. Here we ha
Externí odkaz:
https://doaj.org/article/28fb14bd8fa6477fb7679a5ba2bb6b3c
Autor:
Barbora Vítovcová, Veronika Skarková, Radim Havelek, Jiří Soukup, Ananya Pande, Kateřina Caltová, Emil Rudolf
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f42a3842722844bdb4d9ef27a8a33f41
Autor:
Martin Uher, Miloš Hroch, Rozálie Peřinová, Radim Havelek, Jana Křoustková, Martina Řezáčová, Darina Muthná, Darja Koutová, Jiří Kuneš, Lucie Cahlíková
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 5, Pp 103746- (2022)
In this study, a new series of aliphatic, cyclic, and heterocyclic derivatives of haemanthamine was designed and synthesized to enhance its inhibitory effect on the proliferation and viability of cancer cells. A library of haemanthamine derivatives w
Externí odkaz:
https://doaj.org/article/0b444150ae55421aa2d68d3af1eaeb57
Autor:
Blanka Šestáková, Ladislava Schröterová, Aleš Bezrouk, Dana Čížková, Moustafa Elkalaf, Radim Havelek, Emil Rudolf, Věra Králová
Publikováno v:
Nanomaterials, Vol 12, Iss 12, p 2074 (2022)
Graphene and its derivatives are popular nanomaterials used worldwide in many technical fields and biomedical applications. Due to such massive use, their anticipated accumulation in the environment is inevitable, with a largely unknown chronic influ
Externí odkaz:
https://doaj.org/article/52b454a58e2a4246b6e0ecc00e01d5fd
Autor:
Duong Thuy Bui, Radim Havelek, Karel Královec, Lenka Kubíčková, Jarmila Kuličková, Petr Matouš, Vít Herynek, Jaroslav Kupčík, Darina Muthná, Pavel Řezanka, Ondřej Kaman
Publikováno v:
Nanomaterials, Vol 12, Iss 3, p 428 (2022)
Highly complex nanoparticles combining multimodal imaging with the sensing of physical properties in biological systems can considerably enhance biomedical research, but reports demonstrating the performance of a single nanosized probe in several ima
Externí odkaz:
https://doaj.org/article/ab2754595ecc441e9d25cddb20abca1c
Autor:
Darja Koutová, Radim Havelek, Eva Peterová, Darina Muthná, Karel Královec, Kateřina Breiterová, Lucie Cahlíková, Martina Řezáčová
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 7014 (2021)
Pancracine, a montanine-type Amaryllidaceae alkaloid (AA), is one of the most potent compounds among natural isoquinolines. In previous studies, pancracine exhibited cytotoxic activity against diverse human cancer cell lines in vitro. However, furthe
Externí odkaz:
https://doaj.org/article/3c6abb0a5da748b1b0e96e3056778ebc
Autor:
Alena Mrkvicova, Marcela Chmelarova, Eva Peterova, Radim Havelek, Ivana Baranova, Petra Kazimirova, Emil Rudolf, Martina Rezacova
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210889 (2019)
Histone modifications play a key role in the epigenetic regulation of gene transcription in cancer cells. Histone acetylations are regulated by two classes of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs). HDACs are incr
Externí odkaz:
https://doaj.org/article/61a06da723b444bba29414ee2c4c04d9