Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases.

Autor: Yarnall MTN; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Ioannidi EI; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.; ETH Zürich, Zürich, Switzerland., Schmitt-Ulms C; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Krajeski RN; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Lim J; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Villiger L; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Zhou W; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Jiang K; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Garushyants SK; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Roberts N; Integrated DNA Technologies, Coralville, IA, USA., Zhang L; Integrated DNA Technologies, Coralville, IA, USA., Vakulskas CA; Integrated DNA Technologies, Coralville, IA, USA., Walker JA 2nd; Synthego Corporation, Redwood City, CA, USA., Kadina AP; Synthego Corporation, Redwood City, CA, USA., Zepeda AE; Synthego Corporation, Redwood City, CA, USA., Holden K; Synthego Corporation, Redwood City, CA, USA., Ma H; University of Massachusetts Chan Medical School, Worcester, MA, USA., Xie J; University of Massachusetts Chan Medical School, Worcester, MA, USA., Gao G; University of Massachusetts Chan Medical School, Worcester, MA, USA., Foquet L; Yecuris Corporation, Tualatin, OR, USA., Bial G; Yecuris Corporation, Tualatin, OR, USA., Donnelly SK; PhoenixBio USA Corporation, New York, NY, USA., Miyata Y; PhoenixBio USA Corporation, New York, NY, USA., Radiloff DR; PhoenixBio USA Corporation, New York, NY, USA., Henderson JM; TriLink Biotechnologies LLC, San Diego, CA, USA., Ujita A; TriLink Biotechnologies LLC, San Diego, CA, USA., Abudayyeh OO; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA. omarabu@mit.edu., Gootenberg JS; McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA. jgoot@mit.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2023 Apr; Vol. 41 (4), pp. 500-512. Date of Electronic Publication: 2022 Nov 24.

EGF promotes mammalian cell growth by suppressing cellular senescence.

Autor: Alexander PB; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA., Yuan L; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA., Yang P; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA., Sun T; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA., Chen R; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA., Xiang H; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA., Chen J; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China., Wu H; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China., Radiloff DR; Department of Pediatrics, University of British Columbia, Vancouver, V6T 1Z4, Canada., Wang XF; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

Publikováno v: Cell research [Cell Res] 2015 Jan; Vol. 25 (1), pp. 135-8. Date of Electronic Publication: 2014 Nov 04.

The combination of theophylline and endothelin receptor antagonism improves exercise performance of rats under simulated high altitude.

Autor: Radiloff DR; Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA., Zhao Y, Boico A, Wu C, Shan S, Palmer G, Hamilton K, Irwin D, Hanna G, Piantadosi CA, Schroeder T

Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2012 Oct 15; Vol. 113 (8), pp. 1243-52. Date of Electronic Publication: 2012 Aug 16.

NDRG4 is required for cell cycle progression and survival in glioblastoma cells.

Autor: Schilling SH; Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA., Hjelmeland AB, Radiloff DR, Liu IM, Wakeman TP, Fielhauer JR, Foster EH, Lathia JD, Rich JN, Wang XF, Datto MB

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2009 Sep 11; Vol. 284 (37), pp. 25160-9. Date of Electronic Publication: 2009 Jul 10.

Modeling cancer patient populations in mice: complex genetic and environmental factors.

Autor: Radiloff DR; Department of Pharmacology and Cancer Biology, Molecular Cancer Biology Program, and Integrated Toxicology and Environmental Health Program, Duke University, Durham, NC 27710 USA., Rinella ES, Threadgill DW

Publikováno v: Drug discovery today. Disease models [Drug Discov Today Dis Models] 2008; Vol. 4 (2), pp. 83-88.