Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Radik R. Shafikov"'
Autor:
Nikolai Y. Zyk, Anastasiia S. Garanina, Ekaterina A. Plotnikova, Anton P. Ber, Ekaterina A. Nimenko, Natalia S. Dashkova, Anastasiia A. Uspenskaia, Radik R. Shafikov, Dmitry A. Skvortsov, Stanislav A. Petrov, Andrey A. Pankratov, Nikolai V. Zyk, Alexander G. Majouga, Elena K. Beloglazkina, Aleksei E. Machulkin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11327 (2023)
Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents. In vitro studies of the affin
Externí odkaz:
https://doaj.org/article/a8378698c0ce4a6eae024f4e4f123eb9
Autor:
Yan A. Ivanenkov, Maxim E. Kukushkin, Anastasia A. Beloglazkina, Radik R. Shafikov, Alexander A. Barashkin, Andrey A. Ayginin, Marina S. Serebryakova, Alexander G. Majouga, Dmitry A. Skvortsov, Viktor A. Tafeenko, Elena K. Beloglazkina
Publikováno v:
Molecules, Vol 28, Iss 3, p 1325 (2023)
Novel variously substituted thiohydantoin-based dispiro-indolinones were prepared using a regio- and diastereoselective synthetic route from 5-arylidene-2-thiohydantoins, isatines, and sarcosine. The obtained molecules were subsequently evaluated in
Externí odkaz:
https://doaj.org/article/4d2af309e9a245a297407ee7d7a93b9a
Autor:
Anastasiia A. Uspenskaya, Ekaterina A. Nimenko, Radik R. Shafikov, Nikolay Y. Zyk, Sergei A. Evteev, Natalia S. Dashkova, Yan A. Ivanenkov, Alexander G. Majouga, Dmitry A. Skvortsov, Anastasiia S. Garanina, Elena K. Beloglazkina, Aleksei E. Machulkin
Publikováno v:
Medicinal Chemistry Research. 32:32-37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a781ccd0fcdd6794c4aef449d6e55fb4
https://doi.org/10.1007/s00044-022-03002-w
https://doi.org/10.1007/s00044-022-03002-w
Autor:
Nikolai Y. Zyk, Anton P. Ber, Ekaterina A. Nimenko, Radik R. Shafikov, Sergei A. Evteev, Stanislav A. Petrov, Anastasia A. Uspenskaya, Natalia S. Dashkova, Yan A. Ivanenkov, Dmitry A. Skvortsov, Elena K. Beloglazkina, Alexander G. Majouga, Aleksei E. Machulkin
Publikováno v:
Bioorganicmedicinal chemistry letters. 71
We report an improved series of ligands targeting prostate specific membrane antigen (PSMA). The new compounds were designed by the introduction of changes in the structure of the aromatic fragment at ε-nitrogen atom of lysine that resulted in impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d17b688770307a916c16864578d519
https://pubmed.ncbi.nlm.nih.gov/35661685
https://pubmed.ncbi.nlm.nih.gov/35661685
Autor:
Dmitry A. Skvortsov, Alexey E. Machulkin, Elena K. Beloglazkina, Stanislav A. Petrov, Alexander G. Majouga, Anastasiya A. Uspenskaya, Radik R. Shafikov, Ekaterina A. Nimenko
Publikováno v:
Mendeleev Communications. 30:756-759
Selective ligands of an urea-based prostate specific membrane antigen with a phenylalanine/tyrosine-based dipeptide linker and with a mingled chiral centers configuration and/or substituted aromatic fragments were prepared in seven steps by liquid- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25fff897668a037cdc7c8a2aed83bc89
https://doi.org/10.1016/j.mencom.2020.11.022
https://doi.org/10.1016/j.mencom.2020.11.022
Autor:
Nikolay V. Zyk, Dmitry A Sakharov, Dmitry A. Guk, Vita N. Nikitina, Alexander Erofeev, Dmitrii M. Mazur, Vadim S. Pokrovsky, Anna A. Moiseeva, Alexey E Naumov, Petr V. Gorelkin, Mikhail A. Soldatov, Roman Akasov, Alexander G. Majouga, Victor V. Shapovalov, A. S. Semkina, Mikhail Ya. Melnikov, Irina V Zhirkina, Olga O. Krasnovskaya, Elena K. Beloglazkina, Vladimir I. Pergushov, Viktor A. Tafeenko, Kseniya Yu. Vlasova, Dmitry A. Skvortsov, Saida S Karshieva, Oksana O Ryabaya, Alexander V. Soldatov, Radik R. Shafikov, Vasily M. Gerasimov, Alexander Vaneev
Publikováno v:
Journal of Medicinal Chemistry. 63:13031-13063
A series of 73 ligands and 73 of their Cu+2 and Cu+1 copper complexes with different geometries, oxidation states of the metal, and redox activities were synthesized and characterized. The aim of the study was to establish the structure-activity rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373ce4ec7520c06923e19827b1fba77a
https://doi.org/10.1021/acs.jmedchem.0c01196
https://doi.org/10.1021/acs.jmedchem.0c01196
Autor:
Vasilii Kolmogorov, Elena S. Khazanova, Yan A. Ivanenkov, Sergei V. Kovalev, Nikolay V. Zyk, Anastasia A. Uspenskaya, Alexander G. Majouga, Petr V. Gorelkin, Stanislav A. Petrov, Radik R. Shafikov, Anton P. Ber, Yulia A. Borisova, Dmitry A. Skvortsov, Ekaterina A. Nimenko, Vadim S. Pokrovsky, Elena K. Beloglazkina, Alexander Vaneev, Nikolay Y. Zyk, Alexander Erofeev, Alexander D. Khudyakov, Galina B. Smirnova, Aleksei E. Machulkin
Publikováno v:
European journal of medicinal chemistry. 227
Prostate cancer is one of the most commonly diagnosed men's cancers and remains one of the leading causes of cancer death. The development of approaches to the treatment of this oncological disease is an ongoing process. In this work, we have carried
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62a1b68e92171082e1b27fd3d99713c
https://pubmed.ncbi.nlm.nih.gov/34717125
https://pubmed.ncbi.nlm.nih.gov/34717125
Autor:
Nikolay V. Zyk, Irina V. Saltykova, Anastasiya V Aladinskaya, Alexander Erofeev, Olga O. Krasnovskaya, Radik R. Shafikov, Elena K. Beloglazkina, Anastasiia S Garanina, Oleg Yu. Saveliev, Maxim A. Abakumov, Vladimir I. Polshakov, Ekaterina A. Nimenko, Yan A. Ivanenkov, Aleksei E. Machulkin, Olga A. Dontsova, Emil U Yamansarov, Alexander G. Majouga, Elena S. Khazanova, Anastasia A. Uspenskaya, Anton P. Ber, Galina B. Smirnova, Vadim S. Pokrovsky, Nikolay U. Zyk, Dmitry A. Skvortsov, Petr V. Gorelkin, Stanislav A. Petrov, A. V. Finko, Rauf T Akhmirov
Publikováno v:
Journal of medicinal chemistry. 64(8)
Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), is a suitable target for specific delivery of antitumor drugs and diagnostic agents due to its overexpression in prostate cancer cells. In the current wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2bdb39740f4dc14b677c9a847824bf
https://pubmed.ncbi.nlm.nih.gov/33822606
https://pubmed.ncbi.nlm.nih.gov/33822606
Autor:
E. S. Yudina, Kseniya Yu. Vlasova, Dmitry A. Guk, A. S. Semkina, N. S. Dashkova, Alexander G. Majouga, V. P. Dyadchenko, Olga O. Krasnovskaya, Vladimir I. Pergushov, V. V. Shapovalov, Elena K. Beloglazkina, Nikolai V. Zyk, M. Ya. Mel’nikov, Dmitry A. Skvortsov, M. A. Kosarev, M. P. Rubtsova, Alexander V. Soldatov, Radik R. Shafikov, A. A. Andreeva
Publikováno v:
Dalton Transactions. 47:17357-17366
Synthesis, characterization (HRMS, NMR, EPR, XANES, UV-Vis spectroscopy, and electrochemistry), DNA and BSA binding and in vitro biological screening of two new ferrocene-incorporated thiohydantoin derivatives (5 and 6) and their copper coordination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d327dc2909be78f57489ac226e4b92
https://doi.org/10.1039/c8dt03164a
https://doi.org/10.1039/c8dt03164a
Autor:
E. A. Plotnikova, Raisa I. Yakubovskaya, Nikolay U. Zyk, Yan A. Ivanenkov, Mikhail V. Kavalchuk, Elena K. Beloglazkina, Anastasia V. Aladinskaya, Alexander G. Majouga, Victor Koteliansky, Alexey E. Machulkin, Ekaterina A. Nimenko, Dmitry A. Skvortsov, Nikolay V. Zyk, Anton P. Ber, Radik R. Shafikov, Anastasia A. Uspenskaya
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(16)
Prostate cancer (PC) is the second most commonly occurring cancer in men. Conventional chemotherapy has wide variety of disadvantages such as high systemic toxicity and low selectivity. Targeted drug delivery is a promising approach to decrease side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4714c764aee1e4f4569241a2018a3f2e
https://pubmed.ncbi.nlm.nih.gov/31248772
https://pubmed.ncbi.nlm.nih.gov/31248772