Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Radia M. Johnson"'
Autor:
Radia M. Johnson, Xueping Qu, Chu-Fang Lin, Ling-Yuh Huw, Avinashnarayan Venkatanarayan, Ethan Sokol, Fang-Shu Ou, Nnamdi Ihuegbu, Oliver A. Zill, Omar Kabbarah, Lisa Wang, Richard Bourgon, Felipe de Sousa e Melo, Chris Bolen, Anneleen Daemen, Alan P. Venook, Federico Innocenti, Heinz-Josef Lenz, Carlos Bais
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
ARID1A is an epigenetic regulator mutated in approximately 5% of non-hypermutated colorectal cancer tumors, however, its relationship with treatment response remains to be explored. Here, the authors suggest that ARID1A mutations may confer intrinsic
Externí odkaz:
https://doaj.org/article/4488b89ca7bf43bdb1d09041a86d2a0c
Autor:
Sébastien Tabariès, Matthew G. Annis, Anthoula Lazaris, Stephanie K. Petrillo, Jennifer Huxham, Amri Abdellatif, Vincent Palmieri, Jaclyn Chabot, Radia M. Johnson, Steven Van Laere, Cornelis Verhoef, Yasmina Hachem, Sara Yumeen, Nicholas Meti, Atilla Omeroglu, Gulbeyaz Altinel, Zu-Hua Gao, Alan S. L. Yu, Dirk J. Grünhagen, Peter Vermeulen, Peter Metrakos, Peter M. Siegel
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Tabariès et al. describe that claudin 2 is a promoter of colorectal cancer liver metastasis. Furthermore, high Claudin-2 expression is associated with shorter time to liver-specific recurrence and is a biomarker of replacement type CRC liver metasta
Externí odkaz:
https://doaj.org/article/e2e152566dcd484a9e2503811a8a2aa7
Autor:
Vanessa Y. C. Sung, Jennifer F. Knight, Radia M. Johnson, Yaakov E. Stern, Sadiq M. Saleh, Paul Savage, Anie Monast, Dongmei Zuo, Stéphanie Duhamel, Morag Park
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks both effective patient stratification strategies and therapeutic targets. Whilst elevated levels of the MET receptor tyrosine kinase are associated with TNBCs and pre
Externí odkaz:
https://doaj.org/article/895f8cc93c03496b8b2c201f974c2d24
Autor:
Yibo Xue, Brian Meehan, Elizabeth Macdonald, Sriram Venneti, Xue Qing D. Wang, Leora Witkowski, Petar Jelinic, Tim Kong, Daniel Martinez, Geneviève Morin, Michelle Firlit, Atefeh Abedini, Radia M. Johnson, Regina Cencic, Jay Patibandla, Hongbo Chen, Andreas I. Papadakis, Aurelie Auguste, Iris de Rink, Ron M. Kerkhoven, Nicholas Bertos, Walter H. Gotlieb, Blaise A. Clarke, Alexandra Leary, Michael Witcher, Marie-Christine Guiot, Jerry Pelletier, Josée Dostie, Morag Park, Alexander R. Judkins, Ralf Hass, Douglas A. Levine, Janusz Rak, Barbara Vanderhyden, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability
Externí odkaz:
https://doaj.org/article/a9bfc57c02f44dfc91dacd68ff8a6a66
CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer
Autor:
Zi-Ming Zhao, Susan E. Yost, Katherine E. Hutchinson, Sierra Min Li, Yate-Ching Yuan, Javad Noorbakhsh, Zheng Liu, Charles Warden, Radia M. Johnson, Xiwei Wu, Jeffrey H. Chuang, Yuan Yuan
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Triple negative breast cancer (TNBC) is aggressive with limited treatment options upon recurrence. Molecular discordance between primary and metastatic TNBC has been observed, but the degree of biological heterogeneity has not bee
Externí odkaz:
https://doaj.org/article/839d747b3765477b9803f5c785067477
Autor:
Alison Hirukawa, Harvey W. Smith, Dongmei Zuo, Catherine R. Dufour, Paul Savage, Nicholas Bertos, Radia M. Johnson, Tung Bui, Guillaume Bourque, Mark Basik, Vincent Giguère, Morag Park, William J. Muller
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Histone modifications in cancer can contribute to pathogenesis. Here, the authors demonstrate that targeting epigenetic modifier Ezh2 hinders metastatic behaviour in Luminal B breast cancer models, and highlight a mechanism where Ezh2 contributes to
Externí odkaz:
https://doaj.org/article/08e7c695e7a0496dbcbb93d281626f1b
Autor:
Jennifer F. Knight, Vanessa Y.C. Sung, Elena Kuzmin, Amber L. Couzens, Danielle A. de Verteuil, Colin D.H. Ratcliffe, Paula P. Coelho, Radia M. Johnson, Payman Samavarchi-Tehrani, Tina Gruosso, Harvey W. Smith, Wontae Lee, Sadiq M. Saleh, Dongmei Zuo, Hong Zhao, Marie-Christine Guiot, Ryan R. Davis, Jeffrey P. Gregg, Christopher Moraes, Anne-Claude Gingras, Morag Park
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3191-3205 (2018)
Summary: Triple-negative breast cancers (TNBCs) display a complex spectrum of mutations and chromosomal aberrations. Chromosome 5q (5q) loss is detected in up to 70% of TNBCs, but little is known regarding the genetic drivers associated with this eve
Externí odkaz:
https://doaj.org/article/f4500191f8be42e7bd824f4c692561b2
Autor:
Brian E. Hsu, Sébastien Tabariès, Radia M. Johnson, Sylvia Andrzejewski, Julien Senecal, Camille Lehuédé, Matthew G. Annis, Eric H. Ma, Sandra Völs, LeeAnn Ramsay, Remi Froment, Anie Monast, Ian R. Watson, Zvi Granot, Russell G. Jones, Julie St-Pierre, Peter M. Siegel
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3902-3915.e6 (2019)
Summary: Neutrophils are phenotypically heterogeneous and exert either anti- or pro-metastatic functions. We show that cancer-cell-derived G-CSF is necessary, but not sufficient, to mobilize immature low-density neutrophils (iLDNs) that promote liver
Externí odkaz:
https://doaj.org/article/25f477ee241a49fb82076fe716b1a056
Autor:
Said Izreig, Bozena Samborska, Radia M. Johnson, Alexey Sergushichev, Eric H. Ma, Carine Lussier, Ekaterina Loginicheva, Ariel O. Donayo, Maya C. Poffenberger, Selena M. Sagan, Emma E. Vincent, Maxim N. Artyomov, Thomas F. Duchaine, Russell G. Jones
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1915-1928 (2016)
A central hallmark of cancer cells is the reprogramming of cellular metabolism to meet the bioenergetic and biosynthetic demands of malignant growth. Here, we report that the miR-17∼92 microRNA (miRNA) cluster is an oncogenic driver of tumor metabo
Externí odkaz:
https://doaj.org/article/c358bda8327145d5b97bb7af9103a9a2
Autor:
Paul Savage, Yaakov E. Stern, Jennifer F. Knight, Morag Park, Radia M. Johnson, Sadiq M. Saleh, Stephanie Duhamel, Vanessa Y.C. Sung, Anie Monast, Dongmei Zuo
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)
NPJ Breast Cancer
NPJ Breast Cancer
Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks both effective patient stratification strategies and therapeutic targets. Whilst elevated levels of the MET receptor tyrosine kinase are associated with TNBCs and predict poor