Zobrazeno 1 - 10
of 40
pro vyhledávání: '"RadiÄ M"'
Autor:
Marie-Anne Goyette, Stéphanie Duhamel, Léo Aubert, Ariane Pelletier, Paul Savage, Marie-Pier Thibault, Radia Marie Johnson, Peter Carmeliet, Mark Basik, Louis Gaboury, William J. Muller, Morag Park, Philippe P. Roux, Jean-Philippe Gratton, Jean-François Côté
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113604- (2023)
Externí odkaz:
https://doaj.org/article/d9a9b40ac45647d0834726998922a5ff
Autor:
Radia M. Johnson, Xueping Qu, Chu-Fang Lin, Ling-Yuh Huw, Avinashnarayan Venkatanarayan, Ethan Sokol, Fang-Shu Ou, Nnamdi Ihuegbu, Oliver A. Zill, Omar Kabbarah, Lisa Wang, Richard Bourgon, Felipe de Sousa e Melo, Chris Bolen, Anneleen Daemen, Alan P. Venook, Federico Innocenti, Heinz-Josef Lenz, Carlos Bais
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
ARID1A is an epigenetic regulator mutated in approximately 5% of non-hypermutated colorectal cancer tumors, however, its relationship with treatment response remains to be explored. Here, the authors suggest that ARID1A mutations may confer intrinsic
Externí odkaz:
https://doaj.org/article/4488b89ca7bf43bdb1d09041a86d2a0c
Autor:
Sébastien Tabariès, Matthew G. Annis, Anthoula Lazaris, Stephanie K. Petrillo, Jennifer Huxham, Amri Abdellatif, Vincent Palmieri, Jaclyn Chabot, Radia M. Johnson, Steven Van Laere, Cornelis Verhoef, Yasmina Hachem, Sara Yumeen, Nicholas Meti, Atilla Omeroglu, Gulbeyaz Altinel, Zu-Hua Gao, Alan S. L. Yu, Dirk J. Grünhagen, Peter Vermeulen, Peter Metrakos, Peter M. Siegel
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Tabariès et al. describe that claudin 2 is a promoter of colorectal cancer liver metastasis. Furthermore, high Claudin-2 expression is associated with shorter time to liver-specific recurrence and is a biomarker of replacement type CRC liver metasta
Externí odkaz:
https://doaj.org/article/e2e152566dcd484a9e2503811a8a2aa7
Autor:
Vanessa Y. C. Sung, Jennifer F. Knight, Radia M. Johnson, Yaakov E. Stern, Sadiq M. Saleh, Paul Savage, Anie Monast, Dongmei Zuo, Stéphanie Duhamel, Morag Park
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks both effective patient stratification strategies and therapeutic targets. Whilst elevated levels of the MET receptor tyrosine kinase are associated with TNBCs and pre
Externí odkaz:
https://doaj.org/article/895f8cc93c03496b8b2c201f974c2d24
Autor:
Radia Mahboub
Publikováno v:
Orbital: The Electronic Journal of Chemistry, Vol 13, Iss 1, Pp 33-38 (2021)
We have performing theoretical calculations of the 1,2,4-triazole derivatives using DFT B3LYP method to study the tautomeric conformations of 1,2,4-triazole-3-thiol (TL 2A and TL 2C) and 1,2,4-triazole-3-thione (TL 2B) derivatives. Then, we compare t
Externí odkaz:
https://doaj.org/article/bf4901082fcc44319253800f0732c029
Publikováno v:
Iranian Journal of Chemistry & Chemical Engineering, Vol 38, Iss 6, Pp 261-273 (2019)
The main challenge in Wastewater Treatment Plants (WWTP) by activated sludge process is the reduction of the energy consumption that varies according to the pollutant load of influent. However, this energy is fundamentally used for aerators in a biol
Externí odkaz:
https://doaj.org/article/98577d77666b4ffeadcc13cf41408d31
Autor:
Yibo Xue, Brian Meehan, Elizabeth Macdonald, Sriram Venneti, Xue Qing D. Wang, Leora Witkowski, Petar Jelinic, Tim Kong, Daniel Martinez, Geneviève Morin, Michelle Firlit, Atefeh Abedini, Radia M. Johnson, Regina Cencic, Jay Patibandla, Hongbo Chen, Andreas I. Papadakis, Aurelie Auguste, Iris de Rink, Ron M. Kerkhoven, Nicholas Bertos, Walter H. Gotlieb, Blaise A. Clarke, Alexandra Leary, Michael Witcher, Marie-Christine Guiot, Jerry Pelletier, Josée Dostie, Morag Park, Alexander R. Judkins, Ralf Hass, Douglas A. Levine, Janusz Rak, Barbara Vanderhyden, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability
Externí odkaz:
https://doaj.org/article/a9bfc57c02f44dfc91dacd68ff8a6a66
CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer
Autor:
Zi-Ming Zhao, Susan E. Yost, Katherine E. Hutchinson, Sierra Min Li, Yate-Ching Yuan, Javad Noorbakhsh, Zheng Liu, Charles Warden, Radia M. Johnson, Xiwei Wu, Jeffrey H. Chuang, Yuan Yuan
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Triple negative breast cancer (TNBC) is aggressive with limited treatment options upon recurrence. Molecular discordance between primary and metastatic TNBC has been observed, but the degree of biological heterogeneity has not bee
Externí odkaz:
https://doaj.org/article/839d747b3765477b9803f5c785067477
Autor:
Alison Hirukawa, Harvey W. Smith, Dongmei Zuo, Catherine R. Dufour, Paul Savage, Nicholas Bertos, Radia M. Johnson, Tung Bui, Guillaume Bourque, Mark Basik, Vincent Giguère, Morag Park, William J. Muller
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Histone modifications in cancer can contribute to pathogenesis. Here, the authors demonstrate that targeting epigenetic modifier Ezh2 hinders metastatic behaviour in Luminal B breast cancer models, and highlight a mechanism where Ezh2 contributes to
Externí odkaz:
https://doaj.org/article/08e7c695e7a0496dbcbb93d281626f1b
Autor:
Marie-Anne Goyette, Stéphanie Duhamel, Léo Aubert, Ariane Pelletier, Paul Savage, Marie-Pier Thibault, Radia Marie Johnson, Peter Carmeliet, Mark Basik, Louis Gaboury, William J. Muller, Morag Park, Philippe P. Roux, Jean-Philippe Gratton, Jean-François Côté
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1476-1490 (2018)
Summary: AXL is activated by its ligand GAS6 and is expressed in triple-negative breast cancer cells. In the current study, we report AXL expression in HER2-positive (HER2+) breast cancers where it correlates with poor patient survival. Using murine
Externí odkaz:
https://doaj.org/article/a1e94e9706c3478aad2e0c4c360b7910