Colocalization of Oxtr with Prader-Willi syndrome transcripts in the trigeminal ganglion of neonatal mice

Autor: Fabienne Schaller, Elizabeth A. D. Hammock, Françoise Muscatelli, Radhika Vaidyanathan

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2020, ⟨10.1093/hmg/ddaa094⟩
Human Molecular Genetics, Oxford University Press (OUP), 2020, 29 (12), pp.2065-2075. ⟨10.1093/hmg/ddaa094⟩

Prader-Willi syndrome (PWS) is caused by deficient expression of the paternal copy of several contiguous genes on chromosome 15q11-q13 and affects multiple organ systems in the body, including the nervous system. Feeding and suckling deficits in infa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d15d50cdfca369fc26c6c9ba1db519
https://doi.org/10.1093/hmg/ddaa094

Oxytocin administration in neonates shapes the hippocampal circuitry and restores social behavior in a mouse model of autism

Autor: Roman Tyzio, Elizabeth A. D. Hammock, Fabienne Schaller, Bice Chini, Jinwei Zhang, Alessandra Bertoni, Stephane Gaillard, Diabe Diabira, Jean-Luc Gaiarsa, Françoise Muscatelli, Valéry Matarazzo, Marion Xolin, Francesca Santini, Radhika Vaidyanathan, Igor Medina

Oxytocin is a master regulator of the social brain. In some animal models of autism, notably inMagel2tm1.1Mus-deficient mice, peripheral administration of oxytocin in infancy improves social behaviors until adulthood. However, neither the mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fef39c4ce87b5d9c440f7978c9e00383
https://doi.org/10.1101/2020.09.21.306217

Oxytocin receptor gene loss influences expression of the oxytocin gene in C57BL/6J mice in a sex- and age-dependent manner

Autor: Elizabeth A. D. Hammock, Radhika Vaidyanathan

Publikováno v: J Neuroendocrinol

Parental care and sensory stimulation are critical environmental factors that influence oxytocin (OXT) and its receptor (OXTR). Because developmental Oxt mRNA expression is enhanced by sensory-rich early life experience and reduced by sensory depriva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfdb868c3b44787d0bd62c9195ab434
https://pubmed.ncbi.nlm.nih.gov/31845417

Genetic testing for clinically suspected spinocerebellar ataxias: report from a tertiary referral centre in India

Autor: Sowmya Devatha, Venkatesh, Mahesh, Kandasamy, Nagaraj S, Moily, Radhika, Vaidyanathan, Lakshmi Narayanan, Kota, Syama, Adhikarla, Ravi, Yadav, Pramod Kumar, Pal, Sanjeev, Jain, Meera, Purushottam

Publikováno v: Journal of genetics. 97(1)

Spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative syndromes, characterized by a wide range of muscular weakness and motor deficits, caused due to cerebellar degeneration. The prevalence of the syndromes of SCA varies acros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee38cd958b28c2429e0faf145cace587
https://pubmed.ncbi.nlm.nih.gov/29666341

Trinucleotide repeats and haplotypes at the huntingtin locus in an Indian sample overlaps with European haplogroup a

Autor: Radhika Vaidyanathan, Nagaraj S. Moily, Mahesh Kandasamy, Meera Purushottam, Sanjeev Jain, Lakshmi Narayanan Kota, Pramod Kumar Pal, Ram Murthy Anjanappa, Sowmya Venugopal

Publikováno v: PLoS Currents

Huntington's disease (HD), an autosomal dominant neurodegenerative syndrome, has a world-wide distribution. An estimated 2.5-10/100,000 people of European ancestry are affected with HD, while the Asian populations have lower prevalence (0.6-3.8/100,0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce3742fb3393905cc3b3be480245781
https://pubmed.ncbi.nlm.nih.gov/25642374