Výsledky vyhledávání - "Radhika Rajiv Mahajan"

Akademický článek

Design, pharmacokinetic, and pharmacodynamic evaluation of a lecithin-chitosan hybrid nanoparticle-loaded dual-responsive in situ gel of nebivolol for effective treatment of glaucoma

Autor: Pradeep Singh Rawat, Punna Rao Ravi, Radhika Rajiv Mahajan

Publikováno v: Discover Nano, Vol 19, Iss 1, Pp 1-20 (2024)

Abstract In this research work, optimized nebivolol-loaded lecithin-chitosan hybrid nanoparticles (NEB-LCNPs) were prepared using sequential screening and optimization designs. The design of experiments software (DoE) was used to obtain a robust form

Externí odkaz: https://doaj.org/article/84168f03940f4e23841f4b6d441f4e77

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Akademický článek

Nebivolol Polymeric Nanoparticles-Loaded In Situ Gel for Effective Treatment of Glaucoma: Optimization, Physicochemical Characterization, and Pharmacokinetic and Pharmacodynamic Evaluation

Autor: Pradeep Singh Rawat, Punna Rao Ravi, Mohammed Shareef Khan, Radhika Rajiv Mahajan, Łukasz Szeleszczuk

Publikováno v: Nanomaterials, Vol 14, Iss 16, p 1347 (2024)

Nebivolol hydrochloride (NEB), a 3rd-generation beta-blocker, was recently explored in managing open-angle glaucoma due to its mechanism of action involving nitric oxide release for the vasodilation. To overcome the issue of low ocular bioavailabilit

Externí odkaz: https://doaj.org/article/e2223d00dd884daebb8cd25c75866be0

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Akademický článek

Design and Evaluation of Clove Oil-Based Self-Emulsifying Drug Delivery Systems for Improving the Oral Bioavailability of Neratinib Maleate

Autor: Radhika Rajiv Mahajan, Punna Rao Ravi, Riya Kamlesh Marathe, Ajay Gorakh Dongare, Apoorva Vinayak Prabhu, Łukasz Szeleszczuk

Publikováno v: Pharmaceutics, Vol 16, Iss 8, p 1087 (2024)

Neratinib maleate (NM), a tyrosine kinase inhibitor, is used in the treatment of breast cancer. NM is orally administered at a high dose of 290 mg due to its low solubility and poor dissolution rate at pH > 3, as well as gut-wall metabolism limiting

Externí odkaz: https://doaj.org/article/8cc7983cb3f646dba00a086a7fcf317e

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Akademický článek

Design and Evaluation of Clove Oil-Based Self-Emulsifying Drug Delivery Systems for Improving the Oral Bioavailability of Neratinib Maleate.

Autor: Mahajan, Radhika Rajiv¹ (AUTHOR) p20200469@hyderabad.bits-pilani.ac.in, Ravi, Punna Rao¹ (AUTHOR) h20211460240h@alumni.bits-pilani.ac.in, Marathe, Riya Kamlesh¹ (AUTHOR) h20211460249h@alumni.bits-pilani.ac.in, Dongare, Ajay Gorakh¹ (AUTHOR) h20211460252h@alumni.bits-pilani.ac.in, Prabhu, Apoorva Vinayak¹ (AUTHOR), Szeleszczuk, Łukasz² (AUTHOR) lukasz.szeleszczuk@wum.edu.pl

Publikováno v: Pharmaceutics. Aug2024, Vol. 16 Issue 8, p1087. 23p.

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