Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Radhika MISHRA"'
1
Akademický článek
Metastatic lymph node targeted CTLA4 blockade: a potent intervention for local and distant metastases with minimal ICI-induced pneumonia
Autor: Radhika Mishra, Ariunbuyan Sukhbaatar, Shiro Mori, Tetsuya Kodama
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background Immune checkpoint blockade (ICB) elicits a strong and durable therapeutic response, but its application is limited by disparate responses and its associated immune-related adverse events (irAEs). Previously, in a murine model of l
Externí odkaz: https://doaj.org/article/a609b0ec6f3c4b7d9da4191c4698a9af
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2
Akademický článek
Treatment of false‐negative metastatic lymph nodes by a lymphatic drug delivery system with 5‐fluorouracil
Autor: Honoka Fujii, Sachiko Horie, Ariunbuyan Sukhbaatar, Radhika Mishra, Maya Sakamoto, Shiro Mori, Tetsuya Kodama
Publikováno v: Cancer Medicine, Vol 8, Iss 5, Pp 2241-2251 (2019)
Abstract Metastatic lymph nodes (LNs) may be the origin of systemic metastases. It will be important to develop a strategy that prevents systemic metastasis by treating these LNs at an early stage. False‐negative metastatic LNs, which are found dur
Externí odkaz: https://doaj.org/article/a1d7fa00aadc4141842df6d174928399
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3
Drug formulation augments the therapeutic response of carboplatin administered through a lymphatic drug delivery system
Autor: Radhika Mishra, Ariunbuyan Sukhbaatar, Arunkumar Dorai, Shiro Mori, Kiyoto Shiga, Tetsuya Kodama
Publikováno v: Cancer Science. 114:259-270
Treatment of metastatic lymph nodes (LNs) is challenging due to their unique architecture and biophysical traits. Systemic chemotherapy fails to impede tumor progression in LNs due to poor drug uptake and retention by LNs, resulting in fatal systemic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc1a687220c0ddb416965be33ad3dbb
https://doi.org/10.1111/cas.15599
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6
Study of the physicochemical properties of drugs suitable for administration using a lymphatic drug delivery system
Autor: Tetsuya Kodama, Radhika Mishra, Maya Sakamoto, Ryoichi Fukumura, Shiro Mori, Ariunbuyan Sukhbaatar
Publikováno v: Cancer Science
Lymph node (LN) metastasis is thought to account for 20‐30% of deaths from head and neck cancer. The lymphatic drug delivery system (LDDS) is a new technology that enables the injection of drugs into a sentinel LN (SLN) during the early stage of tu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd6b5843e23ba425389f7302d6ff5e2
http://europepmc.org/articles/PMC8088917
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7
Abstract P046: CTLA4 targeted therapy using the lymphatic drug delivery system for treatment of metastatic lymph nodes
Autor: Radhika Mishra, Ariunbuyan Sukhbaatar, Shiro Mori, Tetsuya Kodama
Publikováno v: Cancer Prevention Research. 16:P046-P046
Background: Metastasis is the prime cause of cancer associated mortality. Lymph nodes (LNs) facilitate the systemic exposure of tumor cells, resulting in fatal systemic metastasis. Treatment of metastatic LNs is therefore imperative. However, success
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::516c6e48e19ca7387962ffadc6008ee9
https://doi.org/10.1158/1940-6215.precprev22-p046
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8
Characterizing perfusion defects in metastatic lymph nodes at an early stage using high-frequency ultrasound and micro-CT imaging
Autor: Shiro Mori, Ariunbuyan Sukhbaatar, Ryoichi Kikuchi, Maya Sakamoto, Tetsuya Kodama, Radhika Mishra, Teppei Yamaki
Publikováno v: Clinicalexperimental metastasis. 38(6)
A perfusion defect in a metastatic lymph node (LN) can be visualized as a localized area of low contrast on contrast-enhanced CT, MRI or ultrasound images. Hypotheses for perfusion defects include abnormal hemodynamics in neovascular vessels or a dec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7a6eeee4f062166360f5f2342b24b6
https://pubmed.ncbi.nlm.nih.gov/34654990
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9
Treatment of false‐negative metastatic lymph nodes by a lymphatic drug delivery system with 5‐fluorouracil
Autor: Tetsuya Kodama, Shiro Mori, Ariunbuyan Sukhbaatar, Maya Sakamoto, Radhika Mishra, Honoka Fujii, Sachiko Horie
Publikováno v: Cancer Medicine, Vol 8, Iss 5, Pp 2241-2251 (2019)
Cancer Medicine
Metastatic lymph nodes (LNs) may be the origin of systemic metastases. It will be important to develop a strategy that prevents systemic metastasis by treating these LNs at an early stage. False‐negative metastatic LNs, which are found during the e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e50109e0322529d09b816f5b7fd6afd
http://hdl.handle.net/10097/00128238
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