Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Radhika Basheer"'
Autor:
Koustav Roy, Xuzhao Zhou, Rintaro Otani, Ping-Chuan Yuan, Shuji Ioka, Kaspar E. Vogt, Tamae Kondo, Nouran H. T. Farag, Haruto Ijiri, Zhaofa Wu, Youhei Chitose, Mao Amezawa, David S. Uygun, Yoan Cherasse, Hiroshi Nagase, Yulong Li, Masashi Yanagisawa, Manabu Abe, Radhika Basheer, Yi-Qun Wang, Tsuyoshi Saitoh, Michael Lazarus
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Optochemistry, an emerging pharmacologic approach in which light is used to selectively activate or deactivate molecules, has the potential to alleviate symptoms, cure diseases, and improve quality of life while preventing uncontrolled drug
Externí odkaz:
https://doaj.org/article/4431e78e019340f7971afef4a23b66d7
Autor:
David S. Uygun, Radhika Basheer
Publikováno v:
Brain Research Bulletin, Vol 188, Iss , Pp 223-232 (2022)
Sleep is vital and the deepest stages of sleep occur within Non-rapid-eye-movement sleep (NREM), defined by high electroencephalographic power in the delta (~0.5–4 Hz) wave frequency range. Delta waves are thought to facilitate a myriad of physical
Externí odkaz:
https://doaj.org/article/72b1815b268743a8b651e425de902ad4
Autor:
David S. Uygun, Chun Yang, Elena R. Tilli, Fumi Katsuki, Erik L. Hodges, James T. McKenna, James M. McNally, Ritchie E. Brown, Radhika Basheer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Uygun et al. show that deletion of GABAA receptors from the thalamic reticular nucleus using CRISPR gene editing in mice boosts the delta waves, indicating a role for GABAA receptors on thalamic reticular nucleus neurons in NREM sleep delta oscillati
Externí odkaz:
https://doaj.org/article/f103563cadb64548a47d87698d2e0166
Autor:
Chun Yang, Andrei Larin, James T. McKenna, Kenneth A. Jacobson, Stuart Winston, Robert E. Strecker, Anna Kalinchuk, Radhika Basheer, Ritchie E. Brown
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promote
Externí odkaz:
https://doaj.org/article/7b3e1e1e253041a2bc951220bd9dc89a
Autor:
Radhika Basheer, Stuart Winston, Fumi Katsuki, Marissa B Anderson-Chernishof, Ritchie E. Brown, James T. McKenna, James M. McNally, Chun Yang, Mackenzie C. Gamble, Abigail Hulverson, Thomas Bellio, John G. McCoy, Erik L. Hodges
Publikováno v:
Brain Struct Funct
The basal forebrain (BF) is involved in arousal, attention, and reward processing but the role of individual BF neuronal subtypes is still being uncovered. Glutamatergic neurons are the least well-understood of the three main BF neurotransmitter phen
Autor:
David S, Uygun, Chun, Yang, Elena R, Tilli, Fumi, Katsuki, Erik L, Hodges, James T, McKenna, James M, McNally, Ritchie E, Brown, Radhika, Basheer
Publikováno v:
Nature communications. 13(1)
Identification of mechanisms which increase deep sleep could lead to novel treatments which promote the restorative effects of sleep. Here, we show that knockdown of the α3 GABA
Autor:
Ritchie E. Brown, Fumi Katsuki, David S. Uygun, Chun Yang, Radhika Basheer, James T. McKenna, James M. McNally, Elena R. Tilli
Identification of mechanisms which increase deep sleep could lead to novel treatments which promote the restorative effects of sleep. Here, knockdown of the α3 GABAA-receptor subunit from parvalbumin neurons in the thalamic reticular nucleus using C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4484f8311b144394355c8aab530fbb9d
https://doi.org/10.1101/2020.12.15.422912
https://doi.org/10.1101/2020.12.15.422912
Autor:
Stuart Winston, Chun Yang, John G. McCoy, Radhika Basheer, Mackenzie C. Gamble, James T. McKenna, Marissa B Anderson-Chernishof, Ritchie E. Brown, James M. McNally, Thomas Bellio, Abigail Hulverson
The basal forebrain (BF) is involved in arousal, attention, and reward processing but the role of individual BF subtypes is still being uncovered. Glutamatergic neurons are the least well-understood of the three major BF neurotransmitter phenotypes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dd5a45ace294da02302069739fe1023
https://doi.org/10.1101/2020.06.17.157479
https://doi.org/10.1101/2020.06.17.157479
Publikováno v:
J Neurophysiol
The type 5 metabotropic glutamate receptor (mGluR5) represents a novel therapeutic target for schizophrenia and other disorders. Schizophrenia is associated with progressive abnormalities in cortical oscillatory processes including reduced spindles (