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of 91
pro vyhledávání: '"Radhashree, Maitra"'
Autor:
Alexander Siegman, Aaron Shaykevich, Danbee Chae, Isaac Silverman, Sanjay Goel, Radhashree Maitra
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7530-7547 (2024)
The KRAS gene is mutated in approximately 45% of colorectal cancer patients. There are currently very few targeted treatments or therapies equipped to directly inhibit KRAS due to its unusual structural intricacies. Erlotinib, an EGFR inhibitor, has
Externí odkaz:
https://doaj.org/article/08004cdcbccf45a08d50130a8c2da875
Autor:
Isaac Silverman, Michael Gerber, Aaron Shaykevich, Yitzchak Stein, Alexander Siegman, Sanjay Goel, Radhashree Maitra
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The RAS genes which code for KRAS, HRAS, and NRAS are three of the most frequently mutated oncogenes responsible for cancer deaths. Tumorigenesis is one of the most significant outcomes of deregulation of RAS GTPases. Although the structures have bee
Externí odkaz:
https://doaj.org/article/6481bb380a4948d9adcd0c40198428e7
Publikováno v:
Diseases, Vol 11, Iss 4, p 142 (2023)
Purpose: To investigate the alterations in the expression of noncoding, micro, and small RNA expression during treatment with oncolytic reovirus in KRAS-mutated colorectal cancer. Methods: Oncolytic reovirus treatment was administered in phase 1 clin
Externí odkaz:
https://doaj.org/article/3d9fc3b0a2bf4774936b37e67ea67863
Autor:
Titto Augustine, Peter John, Tyler Friedman, Jeeshan Jiffry, Hillary Guzik, Rifat Mannan, Riya Gupta, Catherine Delano, John M. Mariadason, Xingxing Zang, Radhashree Maitra, Sanjay Goel
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The majority of colorectal cancers (CRCs) are microsatellite stable (MSS) and resistant to immunotherapy. The current study explores the possibility of using oncolytic reovirus to sensitize MSS CRC to immune checkpoint inhibition. While reovirus redu
Externí odkaz:
https://doaj.org/article/ea7c3c86a49c409689ec5946a20dbf40
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2869 (2023)
BRG1 is one of two catalytic subunits of the SWI/SNF ATP-dependent chromatin-remodeling complex. In cancer, it has been hypothesized that BRG1 acts as a tumor suppressor. Further study has shown that, under certain circumstances, BRG1 acts as an onco
Externí odkaz:
https://doaj.org/article/d9f93fc7f2574af4a62f437d403dc345
Autor:
Ruwan Parakrama, Elisha Fogel, Carol Chandy, Titto Augustine, Matt Coffey, Lydia Tesfa, Sanjay Goel, Radhashree Maitra
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background KRAS mutations are prevalent in 40–45% of patients with colorectal cancer (CRC) and targeting this gene has remained elusive. Viruses are well known immune sensitizing agents. The therapeutic efficacy of oncolytic reovirus in co
Externí odkaz:
https://doaj.org/article/88cb56e4959547eb97786d26285e1c57
Autor:
Tzuriel Sapir, Zaelig Averch, Brian Lerman, Abraham Bodzin, Yeshaya Fishman, Radhashree Maitra
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8606 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a viral agent that causes Coronavirus disease 2019 (COVID-19), a disease that causes flu-like symptoms that, when exacerbated, can have life-threatening consequences. COVID-19 has been l
Externí odkaz:
https://doaj.org/article/82e9735bba43434e9fa232ea618a24e5
Publikováno v:
Cancers, Vol 13, Iss 24, p 6233 (2021)
Patients with metastatic colorectal cancer have a 5-year overall survival of less than 10%. Approximately 45% of patients with metastatic colorectal cancer harbor KRAS mutations. These mutations not only carry a predictive role for the absence of res
Externí odkaz:
https://doaj.org/article/793e44893d164c528dbb04271731e52c
Publikováno v:
Cancers, Vol 14, Iss 1, p 80 (2021)
Non-small cell lung cancers (NSCLCs) account for ~85% of lung cancer cases worldwide. Mammalian lungs are exposed to both endogenous and exogenous estrogens. The expression of estrogen receptors (ERs) in lung cancer cells has evoked the necessity to
Externí odkaz:
https://doaj.org/article/68f3240a49484049adffca5782dd7f60
Autor:
Radhashree Maitra, Matthew Coffey, Himanshu Kharkwal, Sengottuvel Viswanathan, Umang Shah, Imran Chaudhary, Mohammad H. Ghalib, Ruwan Y. Parakrama, Allyson J. Ocean, Sanjay Goel
Supplementary table 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ba916f3216620ad1c92d47d562059f
https://doi.org/10.1158/1535-7163.22520730.v1
https://doi.org/10.1158/1535-7163.22520730.v1